Avaliação de atividade mutagênica de Astronium fraxinifolium, Astronium urundeuva e Serjania marginata Casar

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Impacto do polimorfismo genético do polipeptídeo transportador de ânions orgânicos 1B1 (OATP1B1) na eficácia e segurança da atorvastatina

A atorvastatina, amplamente utilizada no tratamento de dislipidemias, é fármaco inibidor da enzima 3-hidroxi-3-metilglutaril coenzima A redutase (HMG-CoA) redutase que atua na etapa limitante da síntese do colesterol nas células hepáticas. O transporte hepatocelular da atorvastatina é mediado principalmente pelo polipeptídeo transportador de ânions orgânicos (OATP) 1B1, o qual é altamente polimórfico geneticamente e está sujeito a interação com outros fármacos usados na clínica. O presente estudo teve como objetivo revisar a literatura científica baseada em estudos clínicos, in vitro e experimentais a fim de avaliar o impacto de polimorfismos genéticos de OATP1B1 na disposição cinética, eficácia e toxicidade da atorvastatina. Os estudos clínicos demonstram que o polimorfismo c.521T>C, presente nos alelos SLCO1B1 *5 e *15, resulta em alteração funcional da atividade transportadora, sendo que indivíduos homozigotos para o alelo raro C, apresentam maiores concentrações plasmáticas de atorvastatina e seus metabólitos ativos 2-hidroxiatorvastatina e 4- hidroxiatorvastatina. Entretanto, o aumento na concentração plasmática da atorvastatina e seus metabólitos ativos em indivíduos c.521 CC parece não ser acompanhado de redução na concentração dos mesmos no sítio alvo, tendo em vista que não foram encontradas diferenças significativas na redução da LDL-C ou colesterol total quando comparados aos indivíduos homozigotos para o alelo selvagem. O alelo SLCO1B1*15 mostrou-se significativamente associado a miopatia induzida pela atorvastatina, apesar do pequeno número de pacientes investigados. Estudos in vitro em células expressando OATP1B1 são necessários a fim de investigar o impacto do polimorfismo c.521T>C na concentração de atorvastatina nos hepatócitos. Sugere-se ainda que estudos clínicos sejam conduzidos a fim de avaliar se a redução da dose de...

O programa de aquisição de alimentos (PAA) e o programa nacional de alimentação escolar (PNAE) no município de Dracena-SP

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

O impacto da adesão aos diferentes níveis de Governança Corporativa para o desempenho econômico e financeiro de um segmento de empresas

The importance of the capital market to Brazilian economic development, linked to the the fragility of a theoretical framework on the issue, case for developing this research. The agents operating in the capital market seek security and confidence for decision making on their investment in that sense we seek to address the concept and values of Corporate Governance to pay in the Brazilian capital market. The Corporate Governance, in its essence, is the system by which companies are directed and monitored, involving the relationship between shareholders and the board of companies, as well as a set of mechanisms and factors intended to minimize market failures. Seeking to confirm adherence to a more advanced system of corporate governance can result in a favorable financial performance, companies were investigated operating in the financial sector (intermediation, various services and insurance), listed by BM&FBOVESPA. The stock market ranks the corporate governance systems in three levels: Level 1 (rudimentary), Level 2 (intermediate) and New Market Level (advanced). To earn the impact of different levels of Corporate Governance for the outcome of the selected companies were calculated and analyzed accounting ratios of profitability, capital structure and liquidity from the Standardized Financial Statements (DFP), base year 2011, 2012 and 2013

Segurança em redes sem fio: estudo sobre o desenvolvimento de conjuntos de dados para comparação de IDS

Pós-graduação em Engenharia Elétrica - FEIS

Segurança alimentar e gestão municipal: uma investigação a partir de comunidade rural assentada em Araraquara

This paper sought to deepen, investigate and analyze the institutional and organizational obstacles of public policies for food security programs, in a period of change in municipal management. Our aim is besides de obstacles, to identify the efficacy and effectiveness of SAN social network, highlighting the National Program of School Food – PNAE. The analysis focuses the city of Araraquara and its food security program network in its relationship with the settlements, highlighting its cultural and productive particularities.

Occupational exposure to contaminated biological material: perceptions and feelings experienced among dental students

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Nas ondas do oceano: o patrimônio histórico documental das câmaras do Brasil-Colônia no acervo do Conselho Ultramarino

Pós-graduação em História - FCHS

China e a Ásia Central: petróleo, segurança e os Estados Unidos

In the last two decades, the United States have substantially increased their presence in Central Asia. Therefore their presence left China in an uncomfortable position, as China seeks to build a stable and peaceful environment in its near abroad, having under its influence all the countries of Central Asia. One of the ways used by the Chinese government to get closer to the countries of this region is through the oil. Being so, the Chinese oil companies buy rights of exploitation of oil and gas reserves in Central Asia and through this establishes and deepens friendly ties with these countries. This practice became known as oil diplomacy. This new tool of the Chinese government has a double effect: it increases the projection of the Chinese power and dilutes the American influence in the region. In other words, it displeases the United States, and in turn tries to be even more present in Central Asia. The main goal to be worked in this study is how the oil diplomacy increases Chinese influence in Central Asia and dilutes American power in the region. It also aims to explain how the United States uses its presence in Central Asia and on sea lines of communication used to transport oil to contain the Chinese expansion

Sociodrama como instrumento de preparo de jovens para o trabalho

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Direitos humanos e demandas escolares: problematizando a aproximação entre psicologia e conselho tutelar

This paper presents the main achievements in the field of children and youngsters social rights and provides some data on Brazilian education that show the discrepancy between the legal guidelines and the educational situation of children and youngsters within public schools. It presents a critical approach to the ways production and attendance of school problems have been interpreted and shows the dimension in which social facilities established to provide protection to children and adolescents have not been able to ensure a good quality schooling. It highlights the Guardian Council as addressee of school demands and stands out the urgency of debating the violation of fundamental rights such as the lack of quality in education, the repeated situations of failure, and dropping out experienced by a significant number of poor students. The analyzes developed point to the fragility of the relationship between school and Guardian Council revealing an institutional dynamic that individualize social issues. The analyzes developed also suggest the possibility of including Psychology mediation to school, family and Guardian Council. These aim to break the hegemony of the gaze individualizing approach that blame individual and / or family for school failures. This all present to professionals the urgenct for a critical attitude, based on theoretical and practical approaches able to research and propose critical interventions in order to overcome the production of educational exclusion.

Comparative analysis of different meat traceability systems using multiple criteria and a social network approach

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Correlação e visualização de alertas de segurança em redes de computadores

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A problemática trazida pela homologação de sentenças arbitrais estrangeiras anuladas em seu país de origem na segurança jurídica dos contratos internacionais do comercio

Pós-graduação em Direito - FCHS