Neurotoxicity of advanced glycation endproducts during focal stroke and neuroprotective effects of aminoguanidine.

Cerebral infarction (stroke) is a potentially disastrous complication of diabetes mellitus, principally because the extent of cortical loss is greater in diabetic patients than in nondiabetic patients. The etiology of this enhanced neurotoxicity is poorly understood. We hypothesized that advanced glycation endproducts (AGEs), which have previously been implicated in the development of other diabetic complications, might contribute to neurotoxicity and brain damage during ischemic stroke. Using a rat model of focal cerebral ischemia, we show that systemically administered AGE-modified bovine serum albumin (AGE-BSA) significantly increased cerebral infarct size. The neurotoxic effects of AGE-BSA administration were dose- and time-related and associated with a paradoxical increase in cerebral blood flow. Aminoguanidine, an inhibitor of AGE cross-linking, attenuated infarct volume in AGE-treated animals. We conclude that AGEs may contribute to the increased severity of stroke associated with diabetes and other conditions characterized by AGE accumulation.

Evaluation of complex temporal questions in CLEF-QA

This paper presents the evaluation of a QA system for the treatment of complex temporal questions. The system was implemented in a multilayered architecture where complex temporal questions are first decomposed into simple questions, according to the temporal relations expressed in the original question. These simple questions are then processed independently by our standard Question Answering engine and their respective answers are filtered to satisfy the temporal restrictions of each simple question. The answers to the simple decomposed questions are then combined, according to the temporal relations extracted from the original complex question, to give the final answer. This evaluation was performed as a pilot task in the Spanish QA Track of the Cross Language Evaluation Forum 2004.

Application of the Putting Women First protocol in a study on violence against immigrant women in Spain

In this paper, we describe our experience of using the Putting Women First protocol in the design and implementation of a cross-sectional study on violence against women (VAW) among 1607 immigrant women from Morocco, Ecuador and Romania living in Spain in 2011. The Putting Women First protocol is an ethical guideline for VAW research, which includes recommendations to ensure the safety of the women involved in studies on this subject. The response rate in this study was 59.3%. The prevalence of VAW cases last year was 11.7%, of which 15.6% corresponded to Ecuadorian women, 10.9% to Moroccan women and 8.6% to Romanian women. We consider that the most important goal for future research is the use of VAW scales validated in different languages, which would help to overcome the language barriers encountered in this study.

The SAAS-R: A New Instrument to Assess the School Attitudes of Students with High and Low Academic Achievement in Spain

We examined the psychometric properties of the School Attitude Assessment Survey–Revised in a Spanish population (n = 1,398). Confirmatory factor analysis procedures supported the instrument’s five-factor structure. The results of discriminant analysis demonstrated the predictive power of the School Attitude Assessment Survey–Revised scales as regards academic performance. Implications for education and assessment are discussed.

UM Men's Cross Country Team. 1984

Back Row: David Meyer, Joe Schmidt, Dan Smith, coach Ron Warhurst

Front Row: John Chambers, Bob Vandenberg, Bill Brady, Chris Brewster

UM Men's Cross Country Team. 1984

Back Row: Jack Chambers, Marty Newingham, Jeff Costello, Chris Brewster

Bob Vandenberg, Jim Schmidt, Dan Smith

UM Men's Cross Country Team. 1990

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UM Men's Cross Country Team. 1992

Back Row: Ron Warhurst, Jim Finlayson, Matt Joseph, Shawn Mackay, Carlos Paradelo, Jason Colvin, Ian Forsyth, Sean Sweat, Chris Childs, Theo Molla, volunteer coach Dan Heikkinen

Front Row: Mark Kwiatkowski, Jonathan Aubuchon, Brett Smith, Jay Schemanske, Matt Smith, Scott MacDonald, Kristopher Eggle

UM Men's Cross Country Team. 1993

Top Row: Nick Watson, Kevin Sullivan, Ian Forsyth, Theo Molla

Middle Row: David Barnett, Matt Schroeder, Ryan Burt, Kenneth Kozloff, Michael Mahler, Don MacDonald

Front Row: head coach Ron Warhurst, Kris Eggle, Jay Schemanske, Mark Kwiatkowski, Jon Aubuchon

Not pictured: Jim Finlayson, Scott MacDonald, Andy Hayes, Robert Lee, Shawn MacKay, Daniel Shea, Chad Tibbetts

UM Men's Cross Country Team. 1994

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UM Men's Cross Country Team. 1996

Back Row: Jay Cantin, Steve Lawrence, Dan Snyder

Middle Row: Don McLaughlin, Cory Brown, John Mortimer, Todd Snyder, Chris Bunt

Front Row: Jeff Beuche, Kevin Sullivan, coach Ron Warhurst, Scott MacDonald, Dave Barnett, Nick Watson

UM Men's Cross Country Team. 1997

Back Row: asst. coach Dan Heikkinen, Christopher Bunt, Jay Cantin, Don McLaughlin, Kevin Sullivan, John Mortimer, John Bustic, Steven Lawrence, coach Ron Warhurst

Front Row: Cory Brown, Samyar Dorri, Michael Wisniewski, Kurt Lamson, Tom Stamboulian, Alex Towbin, Todd Snyder