Adsorption of methylene blue onto activated carbon produced from steam activated bituminous coal: A study of equilibrium adsorption isotherm.

Chemical Engineering Journal, 124 (2006) 103.

Tourism changes on a Mediterranean island: experiences from Mallorca

Mediterranean islands exemplify well the interactions between tourism, heritage and culture on islands. After an introduction that considers their heritage and the pressures which might be applied by tourism because of insular characteristics such as scale, the paper considers the Spanish island of Mallorca as a case study. First its history and consequent heritage is identified and then various stages in its tourism development, which might be recognized in Butler’s model, are treated with particular reference to two very different foreigner commentators on the island, George Sand and Robert Trimnell. The mass market tourism exemplified by Trimnell has brought a reaction and in recent decades Mallorca has given much more consideration to its environment and heritage, illustrated here through the example of the district of Calvià and its Local Agenda 21 policies. This has seen a considerable impact on the island’s tourism and marketing initiatives, as well as upon its natural environment.

Delivery of Methylene Blue and meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate from cross-linked poly(vinyl alcohol) hydrogels: A potential means of photodynamic therapy of infected wounds

Poly(vinyl alcohol)-borate complexes were evaluated as a potentially novel drug delivery platform suitable for in vivo use in photodynamic antimicrobial chemotherapy (PACT) of wound infections. An optimised formulation (8.0%w/w PVA, 2.0% w/w borax) was loaded with 1.0 mg ml(-1) of the photosensitisers Methylene Blue (MB) and meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate (TMP). Both drugs were released to yield receiver compartment concentrations (>5.0 mu g ml(-1)) found to be phototoxic to both planktonic and bicifilm-grown methicillin-resistant Staphylococcus aureus (MRSA), a common cause of wound infections in hospitals. Newborn calf serum, used to simulate the conditions prevalent in an exuding wound, did not adversely affect the properties of the hydrogels and had no significant effect on the rate of TMP-mediated photodynamic kill of MRSA, despite appreciably reducing the fluence rate of incident light. However, MB-mediated photodynamic kill of MRSA was significantly reduced in the presence of calf serum and when the clinical isolate was grown in a biofilm. Results support the contention that delivery of MB or TMP using gel-type vehicles as part of PACT could make a contribution to the photodynamic eradication of MRSA from infected wounds. (C) 2009 Elsevier B.V. All rights reserved.