Minimum interference routing with fast protection

One of the most effective techniques offering QoS routing is minimum interference routing. However, it is complex in terms of computation time and is not oriented toward improving the network protection level. In order to include better levels of protection, new minimum interference routing algorithms are necessary. Minimizing the failure recovery time is also a complex process involving different failure recovery phases. Some of these phases depend completely on correct routing selection, such as minimizing the failure notification time. The level of protection also involves other aspects, such as the amount of resources used. In this case shared backup techniques should be considered. Therefore, minimum interference techniques should also be modified in order to include sharing resources for protection in their objectives. These aspects are reviewed and analyzed in this article, and a new proposal combining minimum interference with fast protection using shared segment backups is introduced. Results show that our proposed method improves both minimization of the request rejection ratio and the percentage of bandwidth allocated to backup paths in networks with low and medium protection requirements

Determinants of non- response to a second assessment of lifestyle factors and body weight in the EPIC-PANACEA study.

BACKGROUND This paper discusses whether baseline demographic, socio-economic, health variables, length of follow-up and method of contacting the participants predict non-response to the invitation for a second assessment of lifestyle factors and body weight in the European multi-center EPIC-PANACEA study. METHODS Over 500.000 participants from several centers in ten European countries recruited between 1992 and 2000 were contacted 2-11 years later to update data on lifestyle and body weight. Length of follow-up as well as the method of approaching differed between the collaborating study centers. Non-responders were compared with responders using multivariate logistic regression analyses. RESULTS Overall response for the second assessment was high (81.6%). Compared to postal surveys, centers where the participants completed the questionnaire by phone attained a higher response. Response was also high in centers with a short follow-up period. Non-response was higher in participants who were male (odds ratio 1.09 (confidence interval 1.07; 1.11), aged under 40 years (1.96 (1.90; 2.02), living alone (1.40 (1.37; 1.43), less educated (1.35 (1.12; 1.19), of poorer health (1.33 (1.27; 1.39), reporting an unhealthy lifestyle and who had either a low (<18.5 kg/m2, 1.16 (1.09; 1.23)) or a high BMI (>25, 1.08 (1.06; 1.10); especially ≥30 kg/m2, 1.26 (1.23; 1.29)). CONCLUSIONS Cohort studies may enhance cohort maintenance by paying particular attention to the subgroups that are most unlikely to respond and by an active recruitment strategy using telephone interviews.

Sentinel network for monitoring in vitro susceptibility of Plasmodium falciparum to antimalarial drugs in Colombia: a proof of concept

Drug resistance is one of the principal obstacles blocking worldwide malaria control. In Colombia, malaria remains a major public health concern and drug-resistant parasites have been reported. In vitro drug susceptibility assays are a useful tool for monitoring the emergence and spread of drug-resistant Plasmodium falciparum. The present study was conducted as a proof of concept for an antimalarial drug resistance surveillance network based on in vitro susceptibility testing in Colombia. Sentinel laboratories were set up in three malaria endemic areas. The enzyme linked immunosorbent assay-histidine rich protein 2 and schizont maturation methods were used to assess the susceptibility of fresh P. falciparum isolates to six antimalarial drugs. This study demonstrates that an antimalarial drug resistance surveillance network based on in vitro methods is feasible in the field with the participation of a research institute, local health institutions and universities. It could also serve as a model for a regional surveillance network. Preliminary susceptibility results showed widespread chloroquine resistance, which was consistent with previous reports for the Pacific region. However, high susceptibility to dihydroartemisinin and lumefantrine compounds, currently used for treatment in the country, was also reported. The implementation process identified critical points and opportunities for the improvement of network sustainability strategies.

Development and validation of a risk score predicting substantial weight gain over 5 years in middle-aged European men and women.

BACKGROUND Identifying individuals at high risk of excess weight gain may help targeting prevention efforts at those at risk of various metabolic diseases associated with weight gain. Our aim was to develop a risk score to identify these individuals and validate it in an external population. METHODS We used lifestyle and nutritional data from 53°758 individuals followed for a median of 5.4 years from six centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) to develop a risk score to predict substantial weight gain (SWG) for the next 5 years (derivation sample). Assuming linear weight gain, SWG was defined as gaining ≥ 10% of baseline weight during follow-up. Proportional hazards models were used to identify significant predictors of SWG separately by EPIC center. Regression coefficients of predictors were pooled using random-effects meta-analysis. Pooled coefficients were used to assign weights to each predictor. The risk score was calculated as a linear combination of the predictors. External validity of the score was evaluated in nine other centers of the EPIC study (validation sample). RESULTS Our final model included age, sex, baseline weight, level of education, baseline smoking, sports activity, alcohol use, and intake of six food groups. The model's discriminatory ability measured by the area under a receiver operating characteristic curve was 0.64 (95% CI = 0.63-0.65) in the derivation sample and 0.57 (95% CI = 0.56-0.58) in the validation sample, with variation between centers. Positive and negative predictive values for the optimal cut-off value of ≥ 200 points were 9% and 96%, respectively. CONCLUSION The present risk score confidently excluded a large proportion of individuals from being at any appreciable risk to develop SWG within the next 5 years. Future studies, however, may attempt to further refine the positive prediction of the score.

Bioconjugated lanthanide luminescent helicates as multilabels for lab-on-a-chip detection of cancer biomarkers.

The lanthanide binuclear helicate [Eu(2)(L(C2(CO(2)H)))(3)] is coupled to avidin to yield a luminescent bioconjugate EuB1 (Q = 9.3%, tau((5)D(0)) = 2.17 ms). MALDI/TOF mass spectrometry confirms the covalent binding of the Eu chelate and UV-visible spectroscopy allows one to determine a luminophore/protein ratio equal to 3.2. Bio-affinity assays involving the recognition of a mucin-like protein expressed on human breast cancer MCF-7 cells by a biotinylated monoclonal antibody 5D10 to which EuB1 is attached via avidin-biotin coupling demonstrate that (i) avidin activity is little affected by the coupling reaction and (ii) detection limits obtained by time-resolved (TR) luminescence with EuB1 and a commercial Eu-avidin conjugate are one order of magnitude lower than those of an organic conjugate (FITC-streptavidin). In the second part of the paper, conditions for growing MCF-7 cells in 100-200 microm wide microchannels engraved in PDMS are established; we demonstrate that EuB1 can be applied as effectively on this lab-on-a-chip device for the detection of tumour-associated antigens as on MCF-7 cells grown in normal culture vials. In order to exploit the versatility of the ligand used for self-assembling [Ln(2)(L(C2(CO(2)H)))(3)] helicates, which sensitizes the luminescence of both Eu(III) and Tb(III) ions, a dual on-chip assay is proposed in which estrogen receptors (ERs) and human epidermal growth factor receptors (Her2/neu) can be simultaneously detected on human breast cancer tissue sections. The Ln helicates are coupled to two secondary antibodies: ERs are visualized by red-emitting EuB4 using goat anti-mouse IgG and Her2/neu receptors by green-emitting TbB5 using goat anti-rabbit IgG. The fact that the assay is more than 6 times faster and requires 5 times less reactants than conventional immunohistochemical assays provides essential advantages over conventional immunohistochemistry for future clinical biomarker detection.

Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area

Currently, there is a trend of an increasing number of Plasmodium vivaxmalaria cases in China that are imported across its Southeast Asia border, especially in the China-Myanmar border area (CMB). To date, little is known about the genetic diversity of P. vivaxin this region. In this paper, we report the first genome sequencing of a P. vivaxisolate (CMB-1) from a vivax malaria patient in CMB. The sequencing data were aligned onto 96.43% of the P. vivaxSalvador I reference strain (Sal I) genome with 7.84-fold coverage as well as onto 98.32% of 14 Sal I chromosomes. Using the de novoassembly approach, we generated 8,541 scaffolds and assembled a total of 27.1 Mb of sequence into CMB-1 scaffolds. Furthermore, we identified all 295 known virgenes, which is the largest subtelomeric multigene family in malaria parasites. These results provide an important foundation for further research onP. vivaxpopulation genetics.

Searching patterns in painting images with computer vision techniques

This paper presents a pattern recognition method focused on paintings images. The purpose is construct a system able to recognize authors or art styles based on common elements of his work (here called patterns). The method is based on comparing images that contain the same or similar patterns. It uses different computer vision techniques, like SIFT and SURF, to describe the patterns in descriptors, K-Means to classify and simplify these descriptors, and RANSAC to determine and detect good results. The method are good to find patterns of known images but not so good if they are not.

Pesca Turisme Cap de Creus

L'objectiu principal d'aquest treball és la implementació, gestió i organització d’un producte innovador a la Costa Brava nord, el Pesca Turisme Cap de Creus. Entre els objectius secundaris hi trobem, en primer lloc, els de diversificar la oferta turística a l’entorn, potenciant els recursos locals de forma sostenible i amb qualitat i conscienciant al visitant de la necessitat del respecte pel medi ambient i els motius pels quals cal conservar-lo i preservar-lo. En segon lloc potenciar el consum de peix de proximitat el qual s’ha perdut el costum de prendre’n i és molt saludable i també bo de gust. En tercer lloc, sensibilitzar sobre la pesca tradicional com a patrimoni intangible. Notan sols la pesca en sí, sinó també el vocabulari del mar, les arts que s’utilitzen, leseines, els noms dels peixos. En quart lloc, promoure les diferents activitats relacionades amb el mar i el patrimoni marítim que es realitzen en aquest espai. En cinquè lloc donar valor afegit tant a la zona com a l’activitat en sí, dins el context del Cap de Creus, un paratge únic arreu. En sisè lloc, crear sinèrgies amb altres sectors com és el privat per tal de promoure el producte i també perquè s’hi impliqui en el foment de consum de productes locals i de proximitat. I en setè i últim lloc, organitzar, en un futur, esdeveniments o activitats comunes amb altres poblacions de la zona de la Mar d’Amunt, la zona nord del Cap de Creus, relacionades amb el mar

Projecte d'una passarel·la metàl·lica per a vianants amb tauler de fusta sobre el riu Onyar de Girona

Girona és famosa entre d’altres coses pels seus ponts sobre el riu Onyar.El nou pont que es vol projectar es vol situar entre el carrer del Carme i el carrer Emili Grahit de Girona al principi on la llera del riu Onyar comença a ser transitable. El projecte té com a objectiu la projecció (disseny, càlcul i construcció) d’unapassarel•la d’acer sobre el riu Onyar a Girona al seu començament de la zonatransitable a la llera del riu, que permeti el pas de vianants i vehicles rodats nomotoritzats, incloent cadires de rodes, bicicletes, carros de la compra i cotxets d’uncostat a l’altre del riu. Per aconseguir un disseny òptim sense necessitar d’utilitzar mésmaterial del necessari es decideix realitzar una passarel•la amb forma corba i un estudide la biga principal aplicant el mètode dels elements finits a través d’un programacomercial.L’abast del projecte és la de projectar una passarel•la metàl•lica de uns 50 metres dellarg i 4 metres d’amplada. Amb una estructura el mes apurada possible per tal de noutilitzar més material del compte i així poder abaratir costos. El material també ha deser un material bo i resistent a les inclemències meteorològiques per tal de tenir elmenor manteniment possible. A més ha de complir totes les normatives vigents deseguretat

Heritage Sporting Event : An Old Recipe for a New Problem

In the last decades, the globalized competition among cities and regions made them develop new strategies for branding and promoting their territory to attract tourists, investors, companies and residents. Major sports events - such as the Olympic Games, the FIFA World Cup or World and Continental Championships - have played an integral part in these strategies. Believing, with or without evidence, in the capacity of those events to improve the visibility and the economy of the host destination, many cities, regions and even countries have engaged in establishing sports events hosting strategies. The problem of the globalized competition in the sports events "market" is that many cities and regions do not have the resources - either financial, human or in terms of infrastructure - to compete in hosting major sports events. Consequently, many cities or regions have to turn to second-tier sports events. To organise those smaller events means less media coverage and more difficulty in finding sponsors, while the costs - both financial and in terms of services - stay high for the community. This paper analyses how Heritage Sporting Events (HSE) might be an opportunity for cities and regions engaged in sports events hosting strategies. HSE is an emerging concept that to date has been under-researched in the academic literature. Therefore, this paper aims to define the concept of HSE through an exploratory research study. A multidisciplinary literature review reveals two major characteristics of HSEs: the sustainability in the territory and the authenticity of the event constructed through a differentiation process. These characteristics, defined through multiple variables, give us the opportunity to observe the construction process of a sports event into a heritage object. This paper argues that HSEs can be seen as territorial resources that can represent a competitive advantage for host destinations. In conclusion, academics are invited to further research HSEs to better understand their construction process and their impacts on the territory, while local authorities are invited to consider HSEs for the branding and the promotion of their territory.

Hoitotiede

Kokoelma käsittää pääosin Helsingin, Kuopion, Oulun, Tampereen ja Turun yliopistojen sekä Åbo Akademin Hoitotieteen sekä Terveyshallinnon ja -talouden laitosten paperimuotoiseia ja elektronisia opinnäytteitä (pro gradu- ja lisensiaattitutkimuksia sekä väitöskirjoja). Lisäksi kokoelma sisältää WHO:n aineistoa sekä yleiskokoelman monografia ja kausijulkaisuaineistoa

El Màrqueting de Zara i l'efecte de la crisi a Inditex

L’objectiu del nostre treball és estudiar certes parts del màrqueting de Zara i comprovar com ha afectat lacrisi a Inditex. Bàsicament, volíem veure si eren certes algunes de les afirmacions que havíem conegut através de la xarxa i de certs llibres.Per tal de realitzar un millor estudi, hem comparat certes estratègies de màrqueting de Zara amb les deMango i hem comparat els últims resultats econòmics d’Inditex amb els de Mango.Hem comprovat que bastants de les informacions conegudes han estat certes. Com a afirmacions, i pertant, com a conclusions del nostre treball, podem trobar, pel que fa a la primera part del nostre treball, lapart dedicada al màrqueting, que Inditex segueix unes estratègies de màrqueting bastant particulars i,comparant-ho amb Mango, bastant diferents a les d’aquest últim. Per exemple, les estratègies depublicitat seguides per Zara són molt diferents a les de Mango, més endavant explicarem perquè.Una cosa important a destacar, és que en un principi crèiem que Zara no invertia en publicitat, però hemdescobert que sí que ho fa, però, tal com hem dit, d’una manera molt diferent a la de Mango.Continuant amb estratègies de màrqueting, hem de fer menció de l’ús dels aparadors com a publicitat dela marca, entre d’altres coses.Pel que fa a una altra estratègia de màrqueting de Zara, cal dir que hem descobert que el fet de tenir duesbotigues molt properes és beneficiós per Zara, no tant per les vendes, sinó com a forma de publicitat.Un altre punt molt important a tenir en compte és la principal clau de l’èxit de Zara que, segons el nostreestudi, ha resultat ser “La Moda”.Ja per últim, cal dir que podem afirmar la sospita que cada Zara és diferent, segons on està aquest ubicat,tant en tipus de roba com en aparadors, fet que ens demostra que cada Zara va dirigit a un tipus deconsumidor diferent.Pel que fa a la segona part del nostre treball, hem arribat a la conclusió que Zara no ha patit molt per lacrisi, tot i que el seu rendiment econòmic des que va començar aquesta, no ha estat tan bo com altresanys.

Corrector d’autòmats per la plataforma ACME : mòdul pertanyent al Projecte ACME

Fa uns anys un grup de professors del departament d’Informàtica i Matemàtica Aplicada de la Universitat de Girona va decidir endinsar-se al món de l’ensenyament a través d’Internet (e-learning). D’aquí va néixer el projecte ACME (Avaluació Continuada i Millora de l’Ensenyament). Inicialment l’ACME anava dirigit a reduir l’elevat fracàs dels alumnes a les assignatures de matemàtiques. El resultat va ser tan bo que es va ampliar a altrescamps d’estudi com la química o la informàtica, amb tot i això encara hi ha moltes matèries a les quals no dóna suport. Aquest Projecte Final de Carrera neix per donar suport a un nou tipus de problemes dins de la plataforma ACME, els autòmats finits. Aquest nou mòdul inclourà les eines necessàries per poder generar diferents tipus de problemes sobre autòmats finits i la seva posterior correcció, donant suport a les assignatures de LGA (Llenguatges, Gramàtiques i Autòmats) i TALLF (Teoria d’Autòmats i Llenguatges Formals)

Efeitos da Interação Conjunta da Volatilidade das Taxas de Juro e da Dívida nas Decisões de Investimento: Evidências nas Empresas Portuguesas do Setor Industrial

Focalizando, essencialmente, sobre os efeitos da interação. conjunta da volatildade das taxas de juro e da dívida nas decisões de investimento das empresas portuguesas, listadas na Euronext Lisbon, e considerando a composição de dados em séries temporais empilhadas, extraímos 291 observações completas, durante o período de 1999 a 2009. Os resultados encontrados mostram que uma maior exposição ao risco da dívida das empresas portuguesas depende do nível de endividamento. As empresas moderadamente endividadas e amantes do risco não diminuem os seus investimentos, quando se verifica uma maior volatilidade do risco da dívida. Por outro lado, as empresas sobreendividadas e inimigas do risco respondem perante a uma maior volatilidade do risco da dívida, diminuindo os seus investimentos. Além disso, descobrimos que as empresas portuguesas reduzem os seus investimentos face a uma maior volatilidade das taxas de juro. Entretanto, fomos surpreendidos que as empresas portuguesas não reduzem os seus investimentos, face a um efeito marginal das taxas de juro. Este resultado sugere que, o benefício fiscal resultante do efeito de reavaliação da dívida (Lensink et al., 2001), é mais relevante para as empresas sobreendividadas, uma vez que podem atenuar o efeito dos encargos financeiros (Bo e Sterken, 2002).

Informe preliminar del crucero de primavera 1965 (Cabo Blanco - Morro Sama)

Describe la exporación del mar peruano durante el crucero bío-oceanológico 6510-11, a bordo del B.A.P. Unuane, correspondiente a la estación de primavera, de acuerdo al plan operacional trazado para 1965. Básicamente las observaciones se orientan a conocer las condiciones hidrológicas presentes, los aspectos biológicos de desove de la anchoveta, distribución y concentración de cardúmenes atribuibles a anchoveta, distribución de avesguaneras y apreciaciones sobre dispersión y cantidad de organismos planctónicos.