Genaue Untersuchung deß seltsamen jüdischen Wahns von dem Tekupha-Blut, und noch seltsamern Vorgebens, daß daraus ein sonderbar kräfftiger Beweiß für die christliche Religion zu nehmen

welche ... verf. hat Gustav Georg Zeltner

Usefulness of electrocardiographic parameters for risk prediction in arrhythmogenic right ventricular dysplasia

The value of electrocardiographic findings predicting adverse outcome in patients with arrhythmogenic right ventricular dysplasia (ARVD) is not well known. We hypothesized that ventricular depolarization and repolarization abnormalities on the 12-lead surface electrocardiogram (ECG) predict adverse outcome in patients with ARVD. ECGs of 111 patients screened for the 2010 ARVD Task Force Criteria from 3 Swiss tertiary care centers were digitized and analyzed with a digital caliper by 2 independent observers blinded to the outcome. ECGs were compared in 2 patient groups: (1) patients with major adverse cardiovascular events (MACE: a composite of cardiac death, heart transplantation, survived sudden cardiac death, ventricular fibrillation, sustained ventricular tachycardia, or arrhythmic syncope) and (2) all remaining patients. A total of 51 patients (46%) experienced MACE during a follow-up period with median of 4.6 years (interquartile range 1.8 to 10.0). Kaplan-Meier analysis revealed reduced times to MACE for patients with repolarization abnormalities according to Task Force Criteria (p = 0.009), a precordial QRS amplitude ratio (∑QRS mV V1 to V3/∑QRS mV V1 to V6) of ≤ 0.48 (p = 0.019), and QRS fragmentation (p = 0.045). In multivariable Cox regression, a precordial QRS amplitude ratio of ≤ 0.48 (hazard ratio [HR] 2.92, 95% confidence interval [CI] 1.39 to 6.15, p = 0.005), inferior leads T-wave inversions (HR 2.44, 95% CI 1.15 to 5.18, p = 0.020), and QRS fragmentation (HR 2.65, 95% CI 1.1 to 6.34, p = 0.029) remained as independent predictors of MACE. In conclusion, in this multicenter, observational, long-term study, electrocardiographic findings were useful for risk stratification in patients with ARVD, with repolarization criteria, inferior leads TWI, a precordial QRS amplitude ratio of ≤ 0.48, and QRS fragmentation constituting valuable variables to predict adverse outcome.

Ms. hebr. oct. 218 - Maḥzor ke-minhag le-Yisle : Gebetbuch nach dem Ritus L'Isle (Südfrankreich) für das Neujahrsfest

Vorbesitzer: Joseph de Cavaillon

Sēfer orḥôt ṣaddîqîm

Šelōmō Zalman Londn ...

Ketav hap-Pô'îl el jôševê Gālāṭyā : doś heiśṭ oif ṭaiṭš der brif fon Poilus zu di kehiles han-noitzrim di do gwezn zein in der medine Galaṭja

Digitalisat der Ausg. [S.l.], [1734/35]

Sēfer ʿIyyûn Yiṣḥāq : we-halîkôt Yiṣḥāq

še-ḥibbēr Jitzḥak Izk B.-Šô'ēl ... Poznr

Sēfer ḥaqîrôt hal-lēv

... Zelman Ben-...Šimʿôn Weṣlr mē-Fyûrdā

Ḥamiššā ḥūmšê Tôrā bi-lšôn aškenaz : ṣe'ênā û-re'ênā benôt Ṣiyyôn bā-ʿaṭārā

še ʿiṭṭēr lākem ... Yaʿaqôv Ben- ... Yiṣḥāq ... mim-mišpaḥat rabbēnû ... be-q"q Yānôw

Older patients with low Charlson score and high-risk prostate cancer benefit from radical prostatectomy

INTRODUCTION The aim of the study was to identify the appropriate level of Charlson comorbidity index (CCI) in older patients (>70 years) with high-risk prostate cancer (PCa) to achieve survival benefit following radical prostatectomy (RP). METHODS We retrospectively analyzed 1008 older patients (>70 years) who underwent RP with pelvic lymph node dissection for high-risk prostate cancer (preoperative prostate-specific antigen >20 ng/mL or clinical stage ≥T2c or Gleason ≥8) from 14 tertiary institutions between 1988 and 2014. The study population was further grouped into CCI < 2 and ≥2 for analysis. Survival rate for each group was estimated with Kaplan-Meier method and competitive risk Fine-Gray regression to estimate the best explanatory multivariable model. Area under the curve (AUC) and Akaike information criterion were used to identify ideal 'Cut off' for CCI. RESULTS The clinical and cancer characteristics were similar between the two groups. Comparison of the survival analysis using the Kaplan-Meier curve between two groups for non-cancer death and survival estimations for 5 and 10 years shows significant worst outcomes for patients with CCI ≥ 2. In multivariate model to decide the appropriate CCI cut-off point, we found CCI 2 has better AUC and p value in log rank test. CONCLUSION Older patients with fewer comorbidities harboring high-risk PCa appears to benefit from RP. Sicker patients are more likely to die due to non-prostate cancer-related causes and are less likely to benefit from RP.

Nachrichten aus dem Blumen-Reiche : Eine Quartal-Schrift

Gesammlet von L. C. Schmahling, Kirchen-Inspektor und Oberprediger zu Osterwieck ...

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 1025 - Nachweis zur Frage des Geburtshauses von Arthur Schopenhauer in der Heiliggeistgasse in Danzig

u.a. Erwerb des Hauses von Heinrich Floris Schopenhauer 1784;