Lessons Learned from 15 Years of KIMS and 5 Years of ACROSTUDY.

Background: Pharmacoepidemiological surveys provide a valuable contribution to the continued monitoring of drug-related effects in patients with rare disorders. One of the earliest examples of this type of survey is KIGS (Pfizer International Growth Study Database), which has monitored the safety and effectiveness of growth hormone (GH) therapy in GH-deficient children since its inception in 1987. Following closely in the footsteps of KIGS is KIMS (Pfizer International Metabolic Database). As of 2009, KIMS has been collecting data on the long-term safety and clinical outcomes of GH replacement in GH-deficient adults for 15 years. Approximately 5 years ago, the ACROSTUDY database was established to monitor the long-term safety and effectiveness of pegvisomant in patients with acromegaly. Conclusions: By collecting data on the treatment of relatively rare conditions in routine clinical practice, pharmacoepidemiological surveys such as KIMS and ACROSTUDY provide valuable information on the safety and effectiveness of treatment with GH replacement and pegvisomant in the real world.

Iowa Animal Industry News, 2014, Vol. 15, no. 1

Newsletter produced by Department of Agriculture and Land Stewardship about the animal industry in Iowa. Previously titled Animal Industry News.

List of Bid Proposal Holders, April 15, 2014

List of Bid Proposal Holders

Ag Decision Maker, April 2011, Vol. 15, no. 6

A Business Newsletter for Agriculture

Ag Decision Maker, August 2011, Vol. 15, no. 10

A Business Newsletter for Agriculture

Ag Decision Maker, December 2010, Vol. 15, no. 2

A Business Newsletter for Agriculture

Report on a special investigation of the City of Kinross for the period January 15, 2008 through October 31, 2013

Report on a special investigation of the City of Kinross for the period January 15, 2008 through October 31, 2013

Ag Decision Maker, February 2011, Vol. 15, no. 4

A Business Newsletter for Agriculture

Ag Decision Maker, January 2011, Vol. 15, no. 3

A Business Newsletter for Agriculture

Ag Decision Maker, July 2011, Vol. 15, no. 9

A Business Newsletter for Agriculture

Ag Decision Maker, June 2011, Vol. 15, no. 8

A Business Newsletter for Agriculture

Ag Decision Maker, March 2011, Vol. 15, no. 5

A Business Newsletter for Agriculture

Estimativas de repetibilidades e herdabilidades para produção de ovos e pintos com acasalamentos hierárquicos em galinhas para corte

Foram estimadas repetibilidades (r) e herdabilidades (h²) de características reprodutivas de três populações de galinhas para corte do Setor de Aves da ESALQ/USP Piracicaba, SP. Cento e quinze galinhas foram inseminadas segundo um esquema hierárquico, com sêmen de 23 galos amostrados das populações I, II e III no experimento E1 e de outros 23 galos no experimento E2. Foram utilizadas quatro incubações, ou blocos, em cada experimento. Estimativas de r e h² foram obtidas dentro de experimento, pela análise de variância de médias de galinha em cada incubação. As estimativas de r da produção de ovos (POST) foram significativas (P<0,01) e iguais a 0,19±0,05 e 0,32±0,04 nos experimentos E1 e E2, respectivamente. Quanto a eclodibilidade (ECLOD), as h² estimadas de componentes de variância de galos foram 0,14±0,14 no E1 (P>0,05) e 0,26±0,17 no E2 (P<0,05). No tocante a nascimento de pintos (NASC), as h² estimadas (P<0,05) foram 0,18±0,15 (E1) e 0,26±0,17 (E2). No entanto, h² estimadas com base em componentes de fêmea foram significativas (P<0,01) e maiores: no tocante a ECLOD, as estimativas foram 0,77±0,09 e 0,48±0,20 no experimento E1 e E2, respectivamente, e 0,58±0,21 e 0,48±0,20 quanto a nascimento (NASC). Os resultados confirmam que ECLOD e NASC apresentam variabilidade genética aditiva baixa.