900 resultados para 3-20
Resumo:
Die Ausstellung »Der Meister von Flémalle und Rogier van der Weyden«, die vom 21.11.08 bis zum 22.2.09 im Frankfurter Städel und ab dem 20.3.2009 in der Berliner Gemäldegalerie gezeigt wurde, markiert einen neuen – vielleicht für längere Zeit letzten Rekord – in der Kategorie ›Altmeisterausstellungen‹. Die Schau wurde von einem Kenner der Campin/Rogier van der Weyden-Schule, Stephan Kemperdick (Berlin), zusammen mit seinem Kollegen Jochen Sander (Frankfurt a. M.) organisiert. In den Presseankündigungen und in den Katalogtexten wurde die Ausstellung als Chance präsentiert, bestehende Divergenzen bezüglich der Zuschreibung der überlieferten Werke an die beiden Künstler und ihre Werkstätten definitiv auszuräumen. War diese Hoffnung berechtigt? Zweifel sind angebracht.
Resumo:
BACKGROUND: Hyperosmolar therapy, using either mannitol or hypertonic saline (HTS), is considered the treatment of choice for intracranial hypertension. However, hyperosmolar agents may impair coagulation and platelet function, limiting their use in patients at risk for hemorrhage. Despite this, studies evaluating the effects of mannitol compared to other hyperosmolar agents in dogs are largely lacking. The aim of this study was to compare the in vitro effects on global hemostasis and platelet function of 20 % mannitol and 3 % HTS on canine blood. METHODS: Citrated whole blood from 15 healthy dogs was diluted with 0.9 % saline, 20 % mannitol and 3 % HTS in ratios of 1:16 and 1:8. Rotational thromboelastometry (ROTEM) was used to assess clotting time (CT), clot formation time (CFT) and maximal clot firmness (MCF) following extrinsic activation (Ex-tem) and after platelet inhibition (Fib-tem). A platelet function analyzer (PFA-100) was used to assess closure time (CtPFA). RESULTS: No significant differences were observed between untreated whole blood and samples diluted with saline. Samples diluted with both mannitol and HTS were hypocoagulable compared to untreated whole blood samples. At a dilution of 1:16, no significant differences were found between any measured parameter in samples diluted with saline compared to mannitol or HTS. At a 1:8 dilution, CtPFA was prolonged in samples diluted with mannitol and HTS compared to saline, and CtPFA was prolonged more with mannitol than HTS. Ex-tem CT was increased at a 1:8 dilution with mannitol compared to HTS. Ex-tem CFT was prolonged at a 1:8 dilution with both agents compared to saline, and was prolonged more with mannitol than HTS. Ex-tem MCF was reduced at a 1:8 dilution with both agents compared to saline. DISCUSSION AND CONCLUSIONS: Data in this study indicate that both mannitol and HTS affect canine platelet function and whole blood coagulation in vitro in a dose-dependent fashion. The most pronounced effects were observed after high dilutions with mannitol, which impaired platelet aggregation, clot formation time, clot strength, and fibrin formation significantly more than HTS. Further in vivo studies are necessary before recommendations can be made
Resumo:
Athanasius Kircherus
Resumo:
von David Leimdörfer