Nutrimetabonomics: applications for nutritional sciences, with specific reference to gut microbial interactions

Understanding the role of the diet in determining human health and disease is one major objective of modern nutrition. Mammalian biocomplexity necessitates the incorporation of systems biology technologies into contemporary nutritional research. Metabonomics is a powerful approach that simultaneously measures the low-molecular-weight compounds in a biological sample, enabling the metabolic status of a biological system to be characterized. Such biochemical profiles contain latent information relating to inherent parameters, such as the genotype, and environmental factors, including the diet and gut microbiota. Nutritional metabonomics, or nutrimetabonomics, is being increasingly applied to study molecular interactions between the diet and the global metabolic system. This review discusses three primary areas in which nutrimetabonomics has enjoyed successful application in nutritional research: the illumination of molecular relationships between nutrition and biochemical processes; elucidation of biomarker signatures of food components for use in dietary surveillance; and the study of complex trans-genomic interactions between the mammalian host and its resident gut microbiome. Finally, this review illustrates the potential for nutrimetabonomics in nutritional science as an indispensable tool to achieve personalized nutrition.

Flow Field–Flow Fractionation for size analysis and characterization of nanoparticles for applications in Life Sciences

Nanotechnologies are rapidly expanding because of the opportunities that the new materials offer in many areas such as the manufacturing industry, food production, processing and preservation, and in the pharmaceutical and cosmetic industry. Size distribution of the nanoparticles determines their properties and is a fundamental parameter that needs to be monitored from the small-scale synthesis up to the bulk production and quality control of nanotech products on the market. A consequence of the increasing number of applications of nanomaterial is that the EU regulatory authorities are introducing the obligation for companies that make use of nanomaterials to acquire analytical platforms for the assessment of the size parameters of the nanomaterials. In this work, Asymmetrical Flow Field-Flow Fractionation (AF4) and Hollow Fiber F4 (HF5), hyphenated with Multiangle Light Scattering (MALS) are presented as tools for a deep functional characterization of nanoparticles. In particular, it is demonstrated the applicability of AF4-MALS for the characterization of liposomes in a wide series of mediums. Afterwards the technique is used to explore the functional features of a liposomal drug vector in terms of its biological and physical interaction with blood serum components: a comprehensive approach to understand the behavior of lipid vesicles in terms of drug release and fusion/interaction with other biological species is described, together with weaknesses and strength of the method. Afterwards the size characterization, size stability, and conjugation of azidothymidine drug molecules with a new generation of metastable drug vectors, the Metal Organic Frameworks, is discussed. Lastly, it is shown the applicability of HF5-ICP-MS for the rapid screening of samples of relevant nanorisk: rather than a deep and comprehensive characterization it this time shown a quick and smart methodology that within few steps provides qualitative information on the content of metallic nanoparticles in tattoo ink samples.

La nature : revue des sciences et de leurs applications aux arts et à l'industrie.

Cover title.

Traité d'électricité et de magnetisme, et des applications de ces sciences a la chimie....

Mode of access: Internet.

Traité d'électricité et de magnetisme, et des applications de ces sciences a la chimie, a la physiologie et aux arts. principes généraux /

Mode of access: Internet.

Traité d'électricité et de magnetisme, et des applications de ces sciences a la chimie, a la physiologie et aux arts.

Mode of access: Internet.

Elemens de chimie teorique et pratique : avec l'indication des principales applications aux sciences et aux arts ... /

Mode of access: Internet.

De la méthode d'observation dans son applications aux sciences morales et politiques /

Mode of access: Internet.

Élemens de minéralogie appliquée aux sciences chimiques : ouvrage basé sur la méthode de M. Berzélius contenant l'histoire naturelle et metallurgique des substances minerales, leurs applications á la pharmacie, a la Médecine et á l'Economie domestique : suiví d'un précis élémentaire de géognosie /

Contiene: vol. 1.

Élémens de minéralogie appliquée aux sciences chimiques [microform] : ouvrage basé sur le méthode de M. Berzbelius contenant L'Histoire naturelle et métallurgique des substances minérales, leurs applications à la Pharmacie, à la Médecine et à l'Economic domestique : suivi d'un précis élémentaire de géognoise /

Includes index.

Le Cosmos; revue des sciences et de leurs applications

1863 in 2 parts: Science pratique (in 2v.) and Science pure (in 1v.); these form t. 1-3 of the entire set

NASA's space science and applications program : a statement presented to the Committee on Aeronautical and Space Sciences, United States Senate, April 20, 1967 /

"The material in this booklet is a reprint of a portion of that which was prepared by NASA's Office of Space Science and Applications for presentation to the Congress."