Effect of two opposing changes in photoperiod upon age at first egg in layer-hybrid pullets

An experiment was designed to test the response of growing pullets to two changes in photoperiod (an increase from 8 to 14 h followed 5 weeks later by the reverse change, or a decrease from 14 to 8 h followed by an increase). The first change was made either at 35 days or at 56 days of age, to test the influence of age on the responses observed. Control groups were kept oil constant 8-h and constant 14-h photoperiods and the responses to appropriate single changes were also tested. Mean age at first egg varied from 111 days for birds given a single increment at 56 days to 166 days for pullets given an increase in photoperiod at 35 days followed by a reduction at 70 days. Responses to the single changes confirmed earlier reports that sensitivity to change in photoperiod varies with age ill a manner that is quantitatively predictable. Responses to the double changes could be explained by Postulating that the initial change altered the 'physiological age' of the bird to all extent that was also quantitatively predictable. An early increase in photoperiod advances sexual development and makes the bird more sensitive to a subsequent decrease than would be expected by reference to its chronological age. An early decrease in photoperiod delays sexual development, which can have the effect of making the bird more or less sensitive to a subsequent increase since, ill layer-strain pullets, sensitivity to an increment in photoperiod normally increases Lip to about 9 weeks of age but decreases thereafter. Mean age at first egg predicted using these concepts was very highly correlated with observed age at first egg. The results provide a rational basis for constructing a model to predict age at first egg for any combination of increases and decreases in photoperiod applied to growing pullets.

Teacher stance as reflected in feedback on student writing: An empirical study of secondary school teachers in five countries

This study examines the feedback practices of 110 EFL teachers from five different countries (Cyprus, France, Korea, Spain, and Thailand), working in secondary school contexts. All provided feedback on the same student essay. The coding scheme developed to analyse the feedback operates on two axes: the stance the teachers assumed when providing feedback, and the focus of their feedback. Most teachers reacted as language teachers, rather than as readers of communication. The teachers overwhelmingly focused on grammar in their feedback and assumed what we called a Provider role, providing the correct forms for the student. A second role, Initiator, was also present, in which teachers indicate errors or issues to the learner but expect the learner to pick this up and work on it. This role was associated with a more even spread of feedback focus, where teachers also provided feedback on other areas, such as lexis, style and discourse.

Agricultural innovations at a Late Iron Age oppidum: archaeobotanical evidence for flax, food and fodder from Calleva Atrebatum, UK

The development of oppida in the late first millennium BC across north-western Europe represents a major change in settlement form and social organisation. The construction of extensive earthwork systems, the presence of nucleated settlement areas, long-distance trade links and the development of hierarchical societies have been evidenced. These imply that changes in the style and organisation of agriculture would have been required to support these proto-urban population centres. Hypotheses of the subsistence bases of these settlements, ranging from a reliance on surplus arable production from local rural settlements, to an emphasis on pastoral activities, are here reviewed and grounded against a wider understanding of the expansion of agriculture in the Late Iron Age. These agricultural models have not been previously evaluated. This paper presents archaeobotanical data from six well fills from large-scale excavations at Late Iron Age and Early Roman Silchester, a Late Iron Age territorial oppidum and subsequent Roman civitas capital located in central-southern Britain. This is the first large-scale study of waterlogged plant macrofossils from within a settlement area of an oppidum. Waterlogged plant macrofossils were studied from a series of wells within the settlement. An assessment of taphonomy, considering stratigraphic and contextual information, is reported, followed by an analysis of the diverse assemblages of the plant remains through univariate analysis. Key results evidence animal stabling, flax cultivation, hay meadow management and the use of heathland resources. The staple crops cultivated and consumed at Late Iron Age and Early Roman Silchester are consistent with those cultivated in the wider region, whilst a range of imported fruits and flavourings were also present. The adoption of new oil crops and new grassland management shows that agricultural innovations were associated with foddering for animals rather than providing food for the proto-urban population. The evidence from Silchester is compared with other archaeobotanical datasets from oppida in Europe in order to identify key trends in agricultural change.

The impact of social security reform on occupational and retirement behavior : a quantitative assessment for Brazil

Population ageing is a problem that countries will have to cope with within a few years. How would changes in the social security system affect individual behaviour? We develop a multi-sectoral life-cycle model with both retirement and occupational choices to evaluate what are the macroeconomic impacts of social security reforms. We calibrate the model to match 2011 Brazilian economy and perform a counterfactual exercise of the long-run impacts of a recently adopted reform. In 2013, the Brazilian government approximated the two segregated social security schemes, imposing a ceiling on public pensions. In the benchmark equilibrium, our modelling economy is able to reproduce the early retirement claiming, the agents' stationary distribution among sectors, as well as the social security deficit and the public job application decision. In the counterfactual exercise, we find a significant reduction of 55\% in the social security deficit, an increase of 1.94\% in capital-to-output ratio, with both output and capital growing, a delay in retirement claims of public workers and a modification in the structure of agents applying to the public sector job.

Estimativas de parâmetros genéticos para características de crescimento em bovinos da raça Canchim utilizando modelos de dimensão finita

Os objetivos neste trabalho foram avaliar diferentes modelos, em relação aos efeitos maternos considerados, para características de crescimento e estimar os parâmetros genéticos para essas características em bovinos da raça Canchim, por meio de análises uni, bi e multicaracterísticas. As características peso ao nascimento, peso ao desmame, pesos padronizados para 12, 18, 24 e 30 meses de idade em machos e fêmeas e peso adulto de fêmeas foram analisadas utilizando-se quatro modelos com os efeitos aleatórios adicionados em sequência. Os efeitos maternos influenciaram os pesos do nascimento aos 2 anos de idade e o peso à desmama foi o mais afetado pelos efeitos maternos. As estimativas de herdabilidade direta obtidas das análises bi e multicaracterísticas foram superiores àquelas obtidas das análises unicaracterísticas. As estimativas de herdabilidade do efeito genético direto obtidas usando análise multicaracterística foram 0,39 para peso ao nascer; 0,31 para peso à desmama; 0,29 para peso aos 12 meses; 0,28 para peso aos 18 meses; 0,26 para peso aos 24 meses; 0,30 para peso aos 30 meses; e 0,38 para peso à idade adulta. As correlações genéticas estimadas entre pesos obtidos em idades jovens com peso à idade adulta foram altas, acima de 0,79. A seleção com base em características de crescimento em qualquer idade pode promover ganhos genéticos moderados no peso corporal de animais da raça Canchim em todas as idades-padrão, inclusive nos pesos ao nascer e à idade adulta das fêmeas. É importante considerar nas análises os pesos prévios à seleção para estimar parâmetros genéticos para pesos após a seleção. A análise multicaracterística é a mais indicada.

Genetic analysis of visual scores and their relationships to mature female weight in Nellore breed

Dados de 79.884 animais da raça Nelore foram utilizados para estimar parâmetros genéticos e avaliar as relações entre os escores de conformação, precocidade e musculatura obtidos à desmama e ao sobreano e o peso das fêmeas à idade adulta. Utilizou-se o método da máxima verossimilhança restrita, em análise multicaracterísticas, com modelo que incluiu os efeitos genéticos aditivos direto e residual, como aleatórios, e os efeitos fixos de grupo de contemporâneos e, como covariáveis, a idade do animal à pesagem e a idade da mãe ao parto (exceto para o peso das fêmeas à idade adulta). Os grupos contemporâneos à desmama foram definidos pelas variáveis: sexo, rebanho, ano e mês de nascimento, grupo de manejo ao nascimento e à desmama. Na definição de grupo contemporâneo ao sobreano também foi incluída a variável grupo de manejo ao sobreano. Para o peso das fêmeas à idade adulta, o grupo de contemporâneos foi composto por rebanho, ano de nascimento, grupo de manejo ao sobreano, ano e estação da pesagem. Os efeitos genético materno e de ambiente permanente materno também foram incluídos no modelo para análise dos escores de conformação, precocidade e musculatura à desmama. As estimativas de herdabilidade direta obtidas foram 0,18 ± 0,02 para o escore de conformação; 0,21 ± 0,01 para o escore de precocidade; 0,22 ± 0,01 para o escore de musculatura à desmama e 0,24 ± 0,01 para o escore de conformação; 0,27 ± 0,01 para o escore de precocidade; e 0,26 ± 0,01 para o escore de musculatura ao sobreano e 0,42 ± 0,02 para o peso das fêmeas à idade adulta. As correlações genéticas estimadas entre os escores visuais medidos à desmama e ao sobreano foram positivas, variando de média a alta magnitude (0,56 ± 0,03 a 0,85 ± 0,01). Por outro lado, as correlações genéticas estimadas entre os escores visuais e o peso das fêmeas à idade adulta foram positivas e moderadas, variando de 0,21 ± 0,03 a 0,35 ± 0,03. Os resultados obtidos indicam que a seleção de animais com maiores escores visuais, principalmente ao sobreano, deve promover aumento do peso das fêmeas à idade adulta.

Age-related histopathological lesions in the Mongolian gerbil ventral prostate as a good model for studies of spontaneous hormone-related disorders

The Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the prostate lesions were evaluated morphologically, immunohistochemically and quantitatively. The most frequent changes were in epithelial sites and, namely prostatic intraepithelial neoplasias, microinvasive carcinomas and adenocarcinomas. In the stromal compartment, cellular hyperplasia, when verified, was always associated with the sites of anomalous epithelium. Additionally, larger deposition of collagen fibrils, generating stromal fibrosis, was found in all the old gerbils analysed. The quantitative analysis showed that prostatic tissue proportions differed in altered areas, being specific for each lesion type. Isolated nuclear and nucleolar parameters were not effective in diagnosing the malign potential of lesions. However, the cellular proliferation and death indexes indicated larger cellular turnover in invasive lesions such as carcinomas. With these analyses, it could be verified that old gerbils present high propensity to develop spontaneous prostate changes and this may aid in a better understanding of the biological behaviour of human prostate cancer.

Professores aposentados: quais os motivos para o seu retorno à docência?

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Viabilidade de aplicação da seleção precoce e tamanho de parcelas em testes clonais de Eucalyptus spp

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Competição em testes de progênies de eucalipto e suas implicações na seleção e no melhoramento

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Determinação de adenosina deaminase, fator de necrose tumoral-alfa e interleucina-1 em gestantes portadoras de pré-eclâmpsia

Preeclampsia is a specific disorder of pregnancy, characterized by arterial hypertension and proteinuria detected after 20 weeks of gestation. This pathology is associated with hyperuricemia, higher levels of pro-inflammatory cytokines, enhanced leukocyte activation and oxidative stress. Adenosine deaminase (ADA) is an enzyme present in all human tissues and, it is involved with the maturation of the immune system. Although its function is not fully understood, ADA is considered an indicator of cellular inflammation and, its increased serum concentration is observed in inflammatory diseases, such as tuberculosis and rheumatoid arthritis. This study aimed to assess serum ADA levels in preeclamptic patients (PE) compared with normotensive pregnant (NT) and non-pregnant women (NP), and to correlate these values with TNF-α and IL-1β production. Ninety pregnant women were included: 60 were pre-eclamptic and 30 were normotensive matched for gestational age. As control group 20 healthy non-pregnant women matched with pregnant for age were included. Peripheral blood mononuclear cells (PMMC) obtained from the three groups studied were cultured with or without lipopolysaccharide (LPS) for 18h at 37oC, and TNF-α and IL-1β production was assessed in the supernatant of cultures by enzyme immunoassay (ELISA). ADA plasmatic concentration was determined by colorimetric method. The results show that ADA plasma levels were significantly higher in PE group compared with NT and NP groups. A positive correlation between ADA and uric acid levels was detected in preeclamptic women. There was no significant difference in relation to ADA levels when PE patients were classified in early and late-onset PE. The endogenous production of IL-1β and TNF-α by PBMC was significantly higher in PE group than in NT and NP women, showing the activation state of these cells in PE. LPS induced...(Complete abstract click electronic access below)

Tornar-se professor: desvelando a atuação docente no início do exercício da docência

This research, based on authors such as Was (1999), Guarnieri (1996 and 2005), Freitas (2002 and 2007) argue that the understanding of teacher education as a complex continuum aimed at understanding the initiation of the educational performance in the first five years of professional practice, by analyzing the history of teaching teachers early in their career. As we contemplate the specific objectives of interest to examine the training received to enter and work in the classroom and the experiences in teaching at undergraduate students. To perform the empirical study we adopted the use of semi-structured, guided by an outline of issues significant to the conduct of the respondents' narratives. The main results can highlight the difficulties encountered at the beginning of the educational performance are recurrent, data analysis shows that there is a significant increase in the duties of the teacher. With the study arrives at the premise that we must rethink the quality and structure of training courses aimed at improving the quality of performance of professional education, but for this to occur there must be deepening of studies and improvements not only in initial training and in continuing education courses. It is understood here that the training is not solely responsible for the current educational scene, which encompasses the question of the beginner there are many issues to be studied, such as public policies, structuring the curriculum, pay, but the training is beginning to there are faculty prepared to act

La committenza artistica dei Templari e degli Ospitalieri in Emilia Romagna

La tesi di dottorato La committenza artistica dei Templari e degli Ospitalieri in Emilia Romagna cerca attraverso un approccio metodologico multidisciplinare di ricostruire il patrimonio artistico delle commende dei due ordini religioso cavallereschi in regione. La tesi è stata concepita per riflettere anche a livello strutturale la metodologia d’indagine, così un primo capitolo è dedicato all’analisi storica dei due ordini, con particolare attenzione alla comprensione del rapporto tra gli ordini e il mondo dell’arte. Una secondo capitolo invece è incentrato sulla storiografia artistica relativa e sulle impegnative indagini d’archivio, che, soprattutto attraverso l’utilizzo di una vasta documentazione inedita, hanno permesso di fornire nuovi elementi alla definizione della rete degli insediamenti e della loro decorazione. Lo studio prosegue con la specifica ricostruzione storica e storico artistica delle commende attraverso l’indagine sui singoli insediamenti, dove si è cercato di dar conto delle vicende artistiche e della storia dei suoi protagonisti. Contestualmente alla redazione di questo capitolo, riconoscendo la storia, il senso e l’importanza della scuola stilistico-filologica, si procede alla redazione delle schede di catalogo delle opere superstiti, sia di quelle ancora nelle ex-commende sia di quelle che oggi hanno altre collocazioni. Successivamente, senza necessariamente trarre conclusioni definitive su un lavoro di ricerca che per sua natura è in divenire, si argomentano alcune riflessioni sulla natura, i limiti, i caratteri e l’evoluzione della committenza dei due ordini cavallereschi in regione. Si è così riscoperto un patrimonio artistico vasto e articolato che coniuga capolavori con opere di cultura assai più corsiva, ma comunque sempre capace di raccontare la storia dei suoi artefici (alcuni - come Aristotele Fioravanti, Girolamo da Treviso, Pietro Bembo o Ranuccio Farnese - veri e propri protagonisti del loro tempo), in continuo e sostanziale dialogo con le culture artistiche che hanno attraversato la regione, e non solo, tra Medioevo e Modernità.

SerpinB1 protects the mature neutrophil reserve in the bone marrow

SerpinB1 is among the most efficient inhibitors of neutrophil serine proteases--NE, CG, and PR-3--and we investigated here its role in neutrophil development and homeostasis. We found that serpinB1 is expressed in all human bone marrow leukocytes, including stem and progenitor cells. Expression levels were highest in the neutrophil lineage and peaked at the promyelocyte stage, coincident with the production and packaging of the target proteases. Neutrophil numbers were decreased substantially in the bone marrow of serpinB1(-/-) mice. This cellular deficit was associated with an increase in serum G-CSF levels. On induction of acute pulmonary injury, neutrophils were recruited to the lungs, causing the bone marrow reserve pool to be completely exhausted in serpinB1(-/-) mice. Numbers of myeloid progenitors were normal in serpinB1(-/-) bone marrow, coincident with the absence of target protease expression at these developmental stages. Maturation arrest of serpinB1(-/-) neutrophils was excluded by the normal CFU-G growth in vitro and the normal expression in mature neutrophils of early and late differentiation markers. Normal absolute numbers of proliferating neutrophils and pulse-chase kinetic studies in vivo showed that the bone marrow deficit in serpinB1(-/-) mice was largely restricted to mature, postmitotic neutrophils. Finally, upon overnight culture, apoptosis and necrosis were greater in purified bone marrow neutrophils from serpinB1(-/-) compared with WT mice. Collectively, these findings demonstrate that serpinB1 sustains a healthy neutrophil reserve that is required in acute immune responses.