Die Ereignisse in Ungarn seit dem März 1848 : Manifest an die civilisirten Völker Europas im Namen der ungarischen Regierung

Boberach: Der Vertreter Ungarns in Paris wirft der Deutschen Nationalversammlung vor, sie ignoriere "das Treiben des kleinen asiatischen Volkes", der Ungarn, die angeblich alle Nationalitäten dem Magyarismus zum Opfer bringen wollten, und den Siebenbürger Sachsen, sie ließen sich für österreichische Intrigen mißbrauchen

Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.

DTI and VBM reveal white matter changes without associated gray matter changes in patients with idiopathic restless legs syndrome

BACKGROUND AND PURPOSE We evaluated cerebral white and gray matter changes in patients with iRLS in order to shed light on the pathophysiology of this disease. METHODS Twelve patients with iRLS were compared to 12 age- and sex-matched controls using whole-head diffusion tensor imaging (DTI) and voxel-based morphometry (VBM) techniques. Evaluation of the DTI scans included the voxelwise analysis of the fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). RESULTS Diffusion tensor imaging revealed areas of altered FA in subcortical white matter bilaterally, mainly in temporal regions as well as in the right internal capsule, the pons, and the right cerebellum. These changes overlapped with changes in RD. Voxel-based morphometry did not reveal any gray matter alterations. CONCLUSIONS We showed altered diffusion properties in several white matter regions in patients with iRLS. White matter changes could mainly be attributed to changes in RD, a parameter thought to reflect altered myelination. Areas with altered white matter microstructure included areas in the internal capsule which include the corticospinal tract to the lower limbs, thereby supporting studies that suggest changes in sensorimotor pathways associated with RLS.

Personen und Zustände Berlins seit dem 18. März 1848

Boberach: Die Berliner Entwicklung seit der Märzrevolution, die statt zur Volksbewaffnung nur zur Bürgerbewaffnung geführt hat, und die Preußische Nationalversammlung werden kritisiert mit dem Ergebnis, daß die Reaktion das Volk um die Früchte der Märzerrungenschaften brachte

Ludwig Kossuth und Clemens Metternich

Welsch (Projektbearbeiter): Revolutionsroman des früheren Mitherausgebers des Wiener Blatts 'Der Radicale'. Dem französischen Schriftsteller Eugène Sue gewidmet

Politische Charaktere in Oestreich

Boberach: Als Repräsentanten der Neugestaltung Österreichs nach der Revolution werden der Abgeordnete Schuselka und die Minister Frh. v. Pillersdorf [sic!] und Bach behandelt

The Topoisomerase I Inhibitor Irinotecan and the Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Furamidine Synergistically Suppress Murine Lupus Nephritis

OBJECTIVE The treatment of lupus nephritis is still an unmet medical need requiring new therapeutic approaches. Our group found recently that irinotecan, an inhibitor of topoisomerase I (topo I), reversed proteinuria and prolonged survival in mice with advanced lupus nephritis. While irinotecan is known to stabilize the complex of topo I and DNA, the enzyme tyrosyl-DNA phosphodiesterase 1 (TDP-1) functions in an opposing manner by releasing topo I from DNA. Therefore, we undertook this study to test whether the TDP-1 inhibitor furamidine has an additional effect on lupus nephritis when used in combination with irinotecan. METHODS NZB/NZW mice were treated with low-dose irinotecan and furamidine either alone or in combination beginning at age 26 weeks. DNA relaxation was visualized using gel electrophoresis. Binding of anti-double-stranded DNA (anti-dsDNA) antibodies to DNA modified by topo I, TDP-1, and the topo I inhibitor camptothecin was determined by enzyme-linked immunosorbent assay. RESULTS Compared to treatment with either agent alone, simultaneous treatment with low-dose irinotecan and furamidine significantly improved survival of NZB/NZW mice. Similar to what has been previously shown for irinotecan alone, the combination treatment did not change the levels of anti-dsDNA antibodies. In vitro, recombinant TDP-1 increased topo I-mediated DNA relaxation, resulting in enhanced binding of anti-dsDNA antibodies. In combination with topo I and camptothecin, TDP-1 reversed the inhibitory effects of camptothecin on DNA relaxation and anti-dsDNA binding. CONCLUSION Affecting DNA relaxation by the enzymes topo I and TDP-1 and their inhibitors may be a promising approach for the development of new targeted therapies for systemic lupus erythematosus.

Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children

BACKGROUND Children born preterm or with a small size for gestational age are at increased risk for childhood asthma. OBJECTIVE We sought to assess the hypothesis that these associations are explained by reduced airway patency. METHODS We used individual participant data of 24,938 children from 24 birth cohorts to examine and meta-analyze the associations of gestational age, size for gestational age, and infant weight gain with childhood lung function and asthma (age range, 3.9-19.1 years). Second, we explored whether these lung function outcomes mediated the associations of early growth characteristics with childhood asthma. RESULTS Children born with a younger gestational age had a lower FEV1, FEV1/forced vital capacity (FVC) ratio, and forced expiratory volume after exhaling 75% of vital capacity (FEF75), whereas those born with a smaller size for gestational age at birth had a lower FEV1 but higher FEV1/FVC ratio (P < .05). Greater infant weight gain was associated with higher FEV1 but lower FEV1/FVC ratio and FEF75 in childhood (P < .05). All associations were present across the full range and independent of other early-life growth characteristics. Preterm birth, low birth weight, and greater infant weight gain were associated with an increased risk of childhood asthma (pooled odds ratio, 1.34 [95% CI, 1.15-1.57], 1.32 [95% CI, 1.07-1.62], and 1.27 [95% CI, 1.21-1.34], respectively). Mediation analyses suggested that FEV1, FEV1/FVC ratio, and FEF75 might explain 7% (95% CI, 2% to 10%) to 45% (95% CI, 15% to 81%) of the associations between early growth characteristics and asthma. CONCLUSIONS Younger gestational age, smaller size for gestational age, and greater infant weight gain were across the full ranges associated with childhood lung function. These associations explain the risk of childhood asthma to a substantial extent.

The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children.

Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged ≤2 years.Individual data of 27 993 mother-child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders.Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03-1.20) compared with unexposed children. Risk of wheeze was further increased by children's postnatal passive smoke exposure in addition to their mothers' passive exposure during pregnancy (OR 1.29, 95% CI 1.19-1.40) and highest in children with both sources of passive exposure and mothers who smoked actively during pregnancy (OR 1.73, 95% CI 1.59-1.88). Risk of wheeze associated with tobacco smoke exposure was higher in children with an allergic versus nonallergic family history.Maternal passive smoking exposure during pregnancy is an independent risk factor for wheeze in children up to the age of 2 years. Pregnant females should avoid active and passive exposure to tobacco smoke for the benefit of their children's health.

Na 1 Nachlass Max Horkheimer, 26 - Korrespondenzen mit Betty Drury und Fritz Karsen (p. I 13, 280-486)

3 Brief zwischen Gretel Karplus und Max Horkheimer, 10.06.1939, 1939; 8 Briefe zwiachen Liselotte Karplus und Max Horkheimer, 1936-1938; 80 Briefe uns Beilagen sowie Briefwechsel zwischen Betty Drury, Fritz Karsen und Max Horkheimer, 1934-1948; 7 Briefe zwischen Betty Drury und Max Horkheimer, 1938; 4 Briefe zwischen Stephen Duggan vom Institute of International Education, New York, Fritz Karsen und Max Horkheimer, 30.12.1937, 14.02.1938, 24.05.1938; Institute of International Education, New York; 8 Briefe zwischen Oswald Schlockow und Max Horkheimer, 1935-1937; 1 Brief von Max Horkheimer an Katz,... 1940; 2 Briefe zwischen Simon Katzenstein und Max Horkheimer, 04.10.1936, 20.10.1936; 5 Briefe zwischen Thekla Kauffmann 10.12.1938-1939; 4 Briefe und 1 Beilage zwischen Fritz Kaufmann und Max Horkheimer, 1936-1937; 9 Briefe zwischen Rudolf Kayser und Max Horkheimer, 1937-1939; 2 Briefe zwischen Joseph Keil und Max Horkheimer, 21.01.1949, 26.01.1949; 2 Briefe zwischen Werner Kelm und Max Horkheimer, 18.06.1948, 20.06.1948; 1 Brief von Adolf Keller vom World Council of Churches New York an Max Horkheimer; 2 Briefe zwischen Hans Kelsen und Max Horkheimer, 29.02.1936, 26.05.1936; 3 Briefe zwischen Hermann Kesten und Max Horkheimer, 31.01.1947, 1947;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 169 - Antwortschreiben auf die angeforderte Begutachtung der Schopenhauerschen Übersetzung des "Oraculo manual, y arte de prudencia" des Baltasar Gracián

u.a.: Aufenthalt Schopenhauers in Frankfurt am Main; Übersetzungsangaben; Baltasar Gracián; Johann Gottlob von Quandt;