The Virtual International Stroke Trials Archive

Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. Methods - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. Results - ”Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on 15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 6912 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. Conclusions - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning. (Stroke. 2007;38:1905-1910.)

H-infinity control design for time-delay linear systems: a rational transfer function based approach

The aim of this paper is to present new results on H-infinity control synthesis for time-delay linear systems. We extend the use of a finite order LTI system, called comparison system to H-infinity analysis and design. Differently from what can be viewed as a common feature of other control design methods available in the literature to date, the one presented here treats time-delay systems control design with classical numeric routines based on Riccati equations arisen from H-infinity theory. The proposed algorithm is simple, efficient and easy to implement. Some examples illustrating state and output feedback design are solved and discussed in order to put in evidence the most relevant characteristic of the theoretical results. Moreover, a practical application involving a 3-DOF networked control system is presented.

Design of evacuation plans for densely urbanised city centres

The high population density and tightly packed nature of some city centres make emergency planning for these urban spaces especially important, given the potential for human loss in case of disaster. Historic and recent events have made emergency service planners particularly conscious of the need for preparing evacuation plans in advance. This paper discusses a methodological approach for assisting decision-makers in designing urban evacuation plans. The approach aims at quickly and safely moving the population away from the danger zone into shelters. The plans include determining the number and location of rescue facilities, as well as the paths that people should take from their building to their assigned shelter in case of an occurrence requiring evacuation. The approach is thus of the location–allocation–routing type, through the existing streets network, and takes into account the trade-offs among different aspects of evacuation actions that inevitably come up during the planning stage. All the steps of the procedure are discussed and systematised, along with computational and practical implementation issues, in the context of a case study – the design of evacuation plans for the historical centre of an old European city.

Reconciling Function- and Affordance-Based Design

Traditional engineering design methods are based on Simon's (1969) use of the concept function, and as such collectively suffer from both theoretical and practical shortcomings. Researchers in the field of affordance-based design have borrowed from ecological psychology in an attempt to address the blind spots of function-based design, developing alternative ontologies and design processes. This dissertation presents function and affordance theory as both compatible and complimentary. We first present a hybrid approach to design for technology change, followed by a reconciliation and integration of function and affordance ontologies for use in design. We explore the integration of a standard function-based design method with an affordance-based design method, and demonstrate how affordance theory can guide the early application of function-based design. Finally, we discuss the practical and philosophical ramifications of embracing affordance theory's roots in ecology and ecological psychology, and explore the insights and opportunities made possible by an ecological approach to engineering design. The primary contribution of this research is the development of an integrated ontology for describing and designing technological systems using both function- and affordance-based methods.

Vibro-acoustic analysis and design optimization to improve comfort and sustainability of future passenger aircraft

Due to the interest of general public and the industrial stakeholders, new challenges and demands are rising in aircraft design. The sustainability is taking its place amongst more traditional design factors, such as safety, performances and costs. Sustainability is both environmental and economic, and among the factors contributing to economic sustainability, there is also passengers' comfort. In order to win these two challenges, they must be considered in the early stages of aircraft design. In this work, the focus is on emissions generation and acoustic comfort, aiming at reducing pollution and internal noise in the preliminary design phases. These results can be achieved with both unconventional aircraft configurations and advanced materials, which also require new numerical formulations to be assessed. In this research, on one hand, the windowless configuration for a commercial aircraft is studied with traditional preliminary design methods in order to achieve a weight reduction and consequently a return in terms of emissions and costs. On the other hand, a new class of insulating materials, the acoustic metamaterials, is applied on the passenger cabin lining panels. The complex kinematic behaviour of these advanced materials is studied through the Carrera's Unified Formulation, that enhances a wide class of powerful refined shell and beam theories with a unique formulation.

Analysis of a semi-rigid connection for precast concrete

This paper presents a study of a specific type of beam-to-column connection for precast concrete structures. Furthermore, an analytical model to determine the strength and the stiffness of the connection, based on test results of two prototypes, is proposed. To evaluate the influence of the strength and stiffness of the connection on the behaviour of the structure, the results of numerical simulations of a typical multi-storey building with semi-rigid connections are also presented and compared with the results using pinned and rigid connections. The main conclusions are: (a) the proposed design model can reasonably evaluate the studied connection strength; (b) the evaluation of strength is more accurate than that of stiffness; (c) for a typical structure, it is possible to increase the number of storeys of the structure from two to four with lower horizontal displacement at the top, and only a small increase of the column base bending moment by replacing the pinned connections with semi-rigid ones; and (d) although there is significant uncertainty in the connection stiffness, the results show that the displacements at the top of the structure, and the column base moments present low susceptibility deviations to this parameter.

Effect of n-3 fatty acids and statins on oxidative stress in statin-treated hypercholestorelemic and normocholesterolemic women

Introduction: Although the combination of statins with n-3 fatty acids seems to be beneficial under the lipid profile aspect, there is little information about the interaction of these two compounds on oxidative stress. Objective: Evaluate the interaction between statins and n-3 fatty acids on oxidative stress in women, using a 2(2) factorial design. Methods: Forty-three women participated in this crossover design. They were separated into two groups in which 20 were under statin treatment for more than 6 months, and 23 were normolipidemic. Within each group, half of the patients received capsules containing 2.4 g/day of a mixture of EPA and DHA for 6 weeks, while the other half received a mixture of soya and corn oil. After a period of 90 days of washout, the groups were switched, and received the supplementation for 6 weeks more. Results: Statins reduced serum LDL and increased SOD expression. n-3 fatty acids increased the plasma malondialdehyde and SOD activity but reduced catalase expression (p < 0.05). The interaction involving statins and n-3 fatty acids was nearly significant to the serum triacylglycerol reduction (p = 0.054). Conclusion: Combining statins and n-3 fatty acids is an excellent strategy to reduce plasma cholesterol and triacylglycerol concentration in women. However, n-3 fatty acids increased the oxidative stress and the pleiotropic effect of statins seemed to be not enough to counterbalance this result. Our data also suggested that the mechanism by which n-3 fatty acids interfere in oxidative stress can be associated with antioxidant enzymes expression and activity. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

The Preparation of Ternary Solid Dispersions of an Herbal Drug via Spray Drying of Liquid Feed

The present study aimed the preparation and characterization of ternary solid dispersions by direct spray drying of a liquid suspension containing curcumin, a solubility enhancer and a drying aid. The experiments followed a Box-Behnken design in order to evaluate the influence of temperature, ratio of curcumin: lipidic carrier, and the collodial silicon dioxide content on the characteristics of the microparticulated solid dispersions. The angle of repose, Hausner factor, Carr index, water activity, and solubility were used to characterize solid dispersions. The results show that water activity, Hausner factor, and Carr index varied in an acceptable range for pharmaceutical purposes. The condition that maximizes solubility was determined using an exploratory design based on a surface response analysis and allowed a 3200-fold increase in curcumin solubility. Ternary solid dispersion showed a 90% curcumin release after 10min during a dissolution test. The results show that the spray drying of a liquid feed is an attractive and promising alternative to obtain enhanced solubility drug ternary solid dispersions.

Development and implementation of the population Fisher information matrix for the evaluation of population pharmacokinetic designs.

In population pharmacokinetic studies, the precision of parameter estimates is dependent on the population design. Methods based on the Fisher information matrix have been developed and extended to population studies to evaluate and optimize designs. In this paper we propose simple programming tools to evaluate population pharmacokinetic designs. This involved the development of an expression for the Fisher information matrix for nonlinear mixed-effects models, including estimation of the variance of the residual error. We implemented this expression as a generic function for two software applications: S-PLUS and MATLAB. The evaluation of population designs based on two pharmacokinetic examples from the literature is shown to illustrate the efficiency and the simplicity of this theoretic approach. Although no optimization method of the design is provided, these functions can be used to select and compare population designs among a large set of possible designs, avoiding a lot of simulations.

Getting the adrenaline going: Crystal structure of the adrenaline-synthesizing enzyme PNMT

Background: Adrenaline is localized to specific regions of the central nervous system (CNS), but its role therein is unclear because of a lack of suitable pharmacologic agents. Ideally, a chemical is required that crosses the blood-brain barrier, potently inhibits the adrenaline-synthesizing enzyme PNMT, and does not affect other catecholamine processes. Currently available PNMT inhibitors do not meet these criteria. We aim to produce potent, selective, and CNS-active PNMT inhibitors by structure-based design methods. The first step is the structure determination of PNMT. Results: We have solved the crystal structure of human PNMT complexed with a cofactor product and a submicromolar inhibitor at a resolution of 2.4 Angstrom. The structure reveals a highly decorated methyltransferase fold, with an active site protected from solvent by an extensive cover formed from several discrete structural motifs. The structure of PNMT shows that the inhibitor interacts with the enzyme in a different mode from the (modeled) substrate noradrenaline. Specifically, the position and orientation of the amines is not equivalent. Conclusions: An unexpected finding is that the structure of PNMT provides independent evidence of both backward evolution and fold recruitment in the evolution of a complex enzyme from a simple fold. The proposed evolutionary pathway implies that adrenaline, the product of PNMT catalysis, is a relative newcomer in the catecholamine family. The PNMT structure reported here enables the design of potent and selective inhibitors with which to characterize the role of adrenaline in the CNS. Such chemical probes could potentially be useful as novel therapeutics.

A genetic algorithm/method of moments approach to the optimization of an RF coil for MRI applications - Theoretical considerations - Abstract

A Combined Genetic Algorithm and Method of Moments design methods is presented for the design of unusual near-field antennas for use in Magnetic Resonance Imaging systems. The method is successfully applied to the design of an asymmetric coil structure for use at 190MHz and demonstrates excellent radiofrequency field homogeneity.

Projecto de fundações e estrutura de um edifício destinado a pavilhão gimnodesportivo

Este trabalho tem como objectivo a elaboração do projecto de estruturas de um edifício destinado a pavilhão gimnodesportivo, caracterizando as suas diferentes fases de execução, desde a etapa inicial de concepção até à fase final de dimensionamento. Trata-se de um projecto complexo de uma estrutura com elementos estruturais em betão armado e pré-esforçado, e com muros de contenção. Na concepção do edifício foram utilizados os critérios gerais de dimensionamento presentes na regulamentação Europeia (Eurocódigos), uma vez que estes elementos representam o futuro da regulamentação de estruturas em termos Europeus, vindo substituir a nível nacional o “Regulamento de Segurança e Acções para Estruturas de Betão Armado (RSA)” e o “Regulamento para Estruturas de Betão Armado e Pré- Esforçado (REBAP)”. A adopção das normas europeias representam assim um elevado desafio devido ao aumento da complexidade na concepção e dimensionamento de estruturas que estes regulamentos traduzem, principalmente o Eurocódigo 8, que define de um modo mais detalhado e complexo a análise sísmica, relativamente à regulamentação actual em vigor. Devido à elevada complexidade que os projectos de estruturas apresentam, utilizam-se actualmente ferramentas de cálculo automático. No dimensionamento deste edifício foi utilizado um programa tridimensional de elementos finitos para a modelação da estrutura. Pretende-se com a escolha deste projecto e dos métodos de dimensionamento presentes nos Eurocódigos, o desenvolvimento de um trabalho detalhado e correcto, permitindo assim adquirir conhecimentos importantes relativamente às futuras normas, e pôr em prática as competências e os conhecimentos obtidos ao longo curso.

Identificação das categorias mais relevantes da classificação internacional de funcionalidade, incapacidade e saúde para os terapeutas ocupacionais que exercem funções em unidades de cuidados continuados integrados

As constantes alterações das realidades sociais e epidemiológicas em associação ao envelhecimento populacional conduziram a insuficiências dos Sistemas Social e de Saúde que requerem uma reestruturação ao nível da adequação dos cuidados de saúde a prestar, pelo que, em resposta a esta necessidade foi criada a Rede Nacional de Cuidados Continuados Integrados. O presente estudo, de natureza qualitativa e carácter exploratório, tem como objectivo compreender a percepção dos Terapeutas Ocupacionais que trabalham em Unidades de Cuidados Continuados Integrados relativamente às categorias que considerem mais relevantes da Classificação Internacional da Funcionalidade, Incapacidade e Saúde, tendo sido aplicada uma entrevista a 8 profissionais a exercer funções em Unidades da Zona Norte, resultante de um processo de amostragem não probabilística e de conveniência. Como método de recolha de dados foi aplicada uma entrevista semi-estruturada, cujo guião foi construído após revisão bibliográfica, tendo por base as categorias definidas pelo modelo da Classificação Internacional da Funcionalidade, Incapacidade e Saúde e, posteriormente, analisado por um painel de peritos, tendo-se procedido à realização de uma entrevista piloto a um elemento, sem que esta contasse para a análise. A partir da análise das entrevistas realizadas procedemos à identificação das unidades de significado, tendo os conceitos sido ligados às categorias da Classificação que o representam de uma forma mais adequada, de acordo com as linking rules, tendo sido identificadas as categorias mais relevantes para os Terapeutas Ocupacionais a exercer funções em Unidades de Cuidados Continuados Integrados. Com a realização deste estudo, que pretende ser um primeiro passo para a criação de um futuro Core Set em Cuidados Continuados, foi-nos possível verificar que o maior número de categorias foram observadas no componente Actividades e Participação, tendo sido contabilizadas 70 (40,7%). Por outro lado, o componente Estruturas do corpo é o que integra menor número, contando com 19 categorias (11,05%). Assim, pensamos que a criação de um Core Set em Cuidados Continuados poderá beneficiar e facilitar a comunicação entre os profissionais destas equipas. No entanto, é importante ressalvar que a terminologia desta Classificação deverá ser utilizada de uma forma concertada com a linguagem específica da Terapia Ocupacional. Palavras-chave: Classificação Internacional da Funcionalidade, Incapacidade e Saúde, Core Set, Terapeutas Ocupacionais, Unidades de Cuidados Continuados Integrados.

Patrocínio: influência na atitude relativamente à marca e intenção de compra: caso Nike e selecção portuguesa de futebol

Devido à enorme importância que tem sido atribuída ao desporto nas últimas décadas, os marketers abraçam agora totalmente o facto de uma campanha integrada de patrocínio desportivo poder atingir um imensurável número de benefícios. Na verdade, apesar das empresas se comprometerem hoje com muitas outras áreas como a cultura, caridade e domínios humanitários, o desporto continua a ser o campo mais requisitado no que ao patrocínio se refere. Para muitas organizações o patrocínio desportivo é, de facto, o elemento-chave de uma comunicação integrada de marketing. Devido então a todo este enfase dado ao desporto, decidimos verificar se a relação de patrocínio entre a marca Nike e a Selecção Portuguesa de Futebol (SPF) influencia a atitude relativamente à marca e a intenção de compra dos seus produtos, o que constitui o objectivo desta investigação. Assim, tendo como ponto de partida a questão: exercerá a relação de patrocínio entre a Nike e a SPF alguma influência na atitude relativamente à marca e sua intenção de compra? E, por meio de uma revisão da literatura referente a este tema, desenvolvemos um modelo conceptual, o qual é baseado no criado por Martensen et al (2007) e integra quatro principais conceitos: envolvimento, atitudes, intenção de compra e congruência entre a marca e o evento. O presente estudo emprega um design exploratório envolvendo uma colecta de dados quantitativos, através da aplicação de um questionário online. De modo a confirmarmos o modelo proposto, duas técnicas estatísticas foram utilizadas: análise factorial e análise de equações estruturais (AEE). As conclusões desta investigação podem fornecer directivas para a compreensão de como uma relação de patrocínio pode criar ou melhorar a atitude relativamente a uma marca e sua intenção de compra. Como principal resultado, podemos destacar a existência de uma influência positiva da relação de patrocínio na atitude relativamente à marca.

Foresight methodologies to understand changes in the labour process. Experience from Portugal

The foresight and scenario building methods can be an interesting reference for social sciences, especially in terms of innovative methods for labour process analysis. A scenario – as a central concept for the prospective analysis – can be considered as a rich and detailed portrait of a plausible future world. It can be a useful tool for policy-makers to grasp problems clearly and comprehensively, and to better pinpoint challenges as well as opportunities in an overall framework. The features of the foresight methods are being used in some labour policy making experiences. Case studies developed in Portugal will be presented, and some conclusions will be drawn in order to organise a set of principles for foresight analysis applied to the European project WORKS on the work organisation re-structuring in the knowledge society, and on the work design methods for new management structures of virtual organisations.