EFFECTS OF PRENATAL DEXAMETHASONE ON HIPOPCAMPAL SEROTONIN 1A RECEPTORS IN ADULT MALE RATS

The main activation route for the stress response is the hypothalamo-pituitaryadrenal axis (HPA) and the sympatho-adrenomedullary system. The HPA axis is a neuroendocrine feedback loop mediated by an array of tissue specific hormones, receptors and neurotransmitters that regulate glucocorticoid (GC) release. GCs are steroidal hormones produced by the adrenal glands and are key players in a negativefeedback loop controlling HPA activity. They influence the HPA axis through glucocorticoid receptors in the hypothalamus and pituitary and through both glucocorticoid (GR) and mineralcorticoid receptors (MR) that are co-localized in the hippocampus. Repeated or chronic stress exerts a negative influence on these HPA axis regulatory sites and contributes to potentially pathological conditions, especially during early development. For example, chronic stress promotes increased maternal adrenal gland secretion of glucocortiocoid, leading to abnormally high concentrations of GC inthe fetal environment. The timing and maturation of the HPA axis relative to birth is highly species specific and is closely linked to landmarks in fetal development. In rats this development of the HPA axis takes place in utero and continues even shortly after birth. It is likely that the maternal endocrine environment will affect fetal development during this critical time point and may alter the overall set point for the expression ofgenes and their protein products that mediate fetal HPA axis function. Dexamethasone (DEX) is a synthetic glucocorticoid (sGC) and is a consensus treatment in preterm pregnancies used to expedite fetal lung development. However it has been shown that DEX causes long term physiological and behavioral disorders in prenatally-exposed laboratory animals. Previous studies have also shown that it alters the MR: GR receptor ratio in the hippocampus. Taking into consideration corticosteroid regulation of serotonin receptors, especially 5HT1A receptors and their putative interaction with glucocorticoid receptors in the hippocampus, we hypothesized that prenatal DEX exposure would lead to changes in the expression and function of 5HT1A receptors in the hippocampus. We administered DEX to rat dams during the last trimester of gestation and investigated the changes in these receptors in the adult rat offspring. Radioligand receptor binding assays were used to study hippocampal 5HT1A receptor binding affinity and number. Our results demonstrate that hippocampal 5HT1A receptors are increased in the DEX animalscompared with controls by 36%, with no change in binding affinity. The efficiency of ligand-induced receptor signal transduction via G-protein activation was also studied using [35S]GTPγS incorporation assay. Using this technique, we showed that there was no significant difference in the maximum ligand mediated stimulation (Emax) of 5HT1Areceptors between control and dex exposed animals. However, the intracellular signalling efficiency of hippocampal 5HT1A receptors was diminished, since a significant increase in EC50 values was obtained with the dex exposed group showing a value 51% higherEC50 than controls. Taken together these data illustrate a considerable change in the 5HT1A component of the serotonergic system following prenatal DEX exposure.

Dynamic modeling, simulation and control design of a parafoil-payload system for ship launched aerial delivery system (SLADS)

The objective of this research was to develop a high-fidelity dynamic model of a parafoilpayload system with respect to its application for the Ship Launched Aerial Delivery System (SLADS). SLADS is a concept in which cargo can be transfered from ship to shore using a parafoil-payload system. It is accomplished in two phases: An initial towing phase when the glider follows the towing vessel in a passive lift mode and an autonomous gliding phase when the system is guided to the desired point. While many previous researchers have analyzed the parafoil-payload system when it is released from another airborne vehicle, limited work has been done in the area of towing up the system from ground or sea. One of the main contributions of this research was the development of a nonlinear dynamic model of a towed parafoil-payload system. After performing an extensive literature review of the existing methods of modeling a parafoil-payload system, a five degree-of-freedom model was developed. The inertial and geometric properties of the system were investigated to predict accurate results in the simulation environment. Since extensive research has been done in determining the aerodynamic characteristics of a paraglider, an existing aerodynamic model was chosen to incorporate the effects of air flow around the flexible paraglider wing. During the towing phase, it is essential that the parafoil-payload system follow the line of the towing vessel path to prevent an unstable flight condition called ‘lockout’. A detailed study of the causes of lockout, its mathematical representation and the flight conditions and the parameters related to lockout, constitute another contribution of this work. A linearized model of the parafoil-payload system was developed and used to analyze the stability of the system about equilibrium conditions. The relationship between the control surface inputs and the stability was investigated. In addition to stability of flight, one more important objective of SLADS is to tow up the parafoil-payload system as fast as possible. The tension in the tow cable is directly proportional to the rate of ascent of the parafoil-payload system. Lockout instability is more favorable when tow tensions are large. Thus there is a tradeoff between susceptibility to lockout and rapid deployment. Control strategies were also developed for optimal tow up and to maintain stability in the event of disturbances.

HIGH PERFORMANCE, LOW COST SUBSPACE DECOMPOSITION AND POLYNOMIAL ROOTING FOR REAL TIME DIRECTION OF ARRIVAL ESTIMATION: ANALYSIS AND IMPLEMENTATION

This thesis develops high performance real-time signal processing modules for direction of arrival (DOA) estimation for localization systems. It proposes highly parallel algorithms for performing subspace decomposition and polynomial rooting, which are otherwise traditionally implemented using sequential algorithms. The proposed algorithms address the emerging need for real-time localization for a wide range of applications. As the antenna array size increases, the complexity of signal processing algorithms increases, making it increasingly difficult to satisfy the real-time constraints. This thesis addresses real-time implementation by proposing parallel algorithms, that maintain considerable improvement over traditional algorithms, especially for systems with larger number of antenna array elements. Singular value decomposition (SVD) and polynomial rooting are two computationally complex steps and act as the bottleneck to achieving real-time performance. The proposed algorithms are suitable for implementation on field programmable gated arrays (FPGAs), single instruction multiple data (SIMD) hardware or application specific integrated chips (ASICs), which offer large number of processing elements that can be exploited for parallel processing. The designs proposed in this thesis are modular, easily expandable and easy to implement. Firstly, this thesis proposes a fast converging SVD algorithm. The proposed method reduces the number of iterations it takes to converge to correct singular values, thus achieving closer to real-time performance. A general algorithm and a modular system design are provided making it easy for designers to replicate and extend the design to larger matrix sizes. Moreover, the method is highly parallel, which can be exploited in various hardware platforms mentioned earlier. A fixed point implementation of proposed SVD algorithm is presented. The FPGA design is pipelined to the maximum extent to increase the maximum achievable frequency of operation. The system was developed with the objective of achieving high throughput. Various modern cores available in FPGAs were used to maximize the performance and details of these modules are presented in detail. Finally, a parallel polynomial rooting technique based on Newton’s method applicable exclusively to root-MUSIC polynomials is proposed. Unique characteristics of root-MUSIC polynomial’s complex dynamics were exploited to derive this polynomial rooting method. The technique exhibits parallelism and converges to the desired root within fixed number of iterations, making this suitable for polynomial rooting of large degree polynomials. We believe this is the first time that complex dynamics of root-MUSIC polynomial were analyzed to propose an algorithm. In all, the thesis addresses two major bottlenecks in a direction of arrival estimation system, by providing simple, high throughput, parallel algorithms.

Regulation of hematopoietic and leukemic stem cells by the immune system.

Hematopoietic stem cells (HSCs) are rare, multipotent cells that generate via progenitor and precursor cells of all blood lineages. Similar to normal hematopoiesis, leukemia is also hierarchically organized and a subpopulation of leukemic cells, the leukemic stem cells (LSCs), is responsible for disease initiation and maintenance and gives rise to more differentiated malignant cells. Although genetically abnormal, LSCs share many characteristics with normal HSCs, including quiescence, multipotency and self-renewal. Normal HSCs reside in a specialized microenvironment in the bone marrow (BM), the so-called HSC niche that crucially regulates HSC survival and function. Many cell types including osteoblastic, perivascular, endothelial and mesenchymal cells contribute to the HSC niche. In addition, the BM functions as primary and secondary lymphoid organ and hosts various mature immune cell types, including T and B cells, dendritic cells and macrophages that contribute to the HSC niche. Signals derived from the HSC niche are necessary to regulate demand-adapted responses of HSCs and progenitor cells after BM stress or during infection. LSCs occupy similar niches and depend on signals from the BM microenvironment. However, in addition to the cell types that constitute the HSC niche during homeostasis, in leukemia the BM is infiltrated by activated leukemia-specific immune cells. Leukemic cells express different antigens that are able to activate CD4(+) and CD8(+) T cells. It is well documented that activated T cells can contribute to the control of leukemic cells and it was hoped that these cells may be able to target and eliminate the therapy-resistant LSCs. However, the actual interaction of leukemia-specific T cells with LSCs remains ill-defined. Paradoxically, many immune mechanisms that evolved to activate emergency hematopoiesis during infection may actually contribute to the expansion and differentiation of LSCs, promoting leukemia progression. In this review, we summarize mechanisms by which the immune system regulates HSCs and LSCs.

Coupled human and natural system dynamics as key to the sustainability of Lake Victoria's ecosystem services

East Africa’s Lake Victoria provides resources and services to millions of people on the lake’s shores and abroad. In particular, the lake’s fisheries are an important source of protein, employment, and international economic connections for the whole region. Nonetheless, stock dynamics are poorly understood and currently unpredictable. Furthermore, fishery dynamics are intricately connected to other supporting services of the lake as well as to lakeshore societies and economies. Much research has been carried out piecemeal on different aspects of Lake Victoria’s system; e.g., societies, biodiversity, fisheries, and eutrophication. However, to disentangle drivers and dynamics of change in this complex system, we need to put these pieces together and analyze the system as a whole. We did so by first building a qualitative model of the lake’s social-ecological system. We then investigated the model system through a qualitative loop analysis, and finally examined effects of changes on the system state and structure. The model and its contextual analysis allowed us to investigate system-wide chain reactions resulting from disturbances. Importantly, we built a tool that can be used to analyze the cascading effects of management options and establish the requirements for their success. We found that high connectedness of the system at the exploitation level, through fisheries having multiple target stocks, can increase the stocks’ vulnerability to exploitation but reduce society’s vulnerability to variability in individual stocks. We describe how there are multiple pathways to any change in the system, which makes it difficult to identify the root cause of changes but also broadens the management toolkit. Also, we illustrate how nutrient enrichment is not a self-regulating process, and that explicit management is necessary to halt or reverse eutrophication. This model is simple and usable to assess system-wide effects of management policies, and can serve as a paving stone for future quantitative analyses of system dynamics at local scales.

Cosmogenic 180W variations in meteorites and re-assessment of a possible 184Os–180W decay system

We measured tungsten (W) isotopes in 23 iron meteorites and the metal phase of the CB chondrite Gujba in order to ascertain if there is evidence for a large-scale nucleosynthetic heterogeneity in the p-process isotope 180W in the solar nebula as recently suggested by Schulz et al. (2013). We observed large excesses in 180W (up to ≈ 6 ε) in some irons. However, significant within-group variations in magmatic IIAB and IVB irons are not consistent with a nucleosynthetic origin, and the collateral effects on 180W from an s-deficit in IVB irons cannot explain the total variation. We present a new model for the combined effects of spallation and neutron capture reactions on 180W in iron meteorites and show that at least some of the observed within-group variability is explained by cosmic ray effects. Neutron capture causes burnout of 180W, whereas spallation reactions lead to positive shifts in 180W. These effects depend on the target composition and cosmic-ray exposure duration; spallation effects increase with Re/W and Os/W ratios in the target and with exposure age. The correlation of 180W/184W with Os/W ratios in iron meteorites results in part from spallogenic production of 180W rather than from 184Os decay, contrary to a recent study by Peters et al. (2014). Residual ε180W excesses after correction for an s-deficit and for cosmic ray effects may be due to ingrowth of 180W from 184Os decay, but the magnitude of this ingrowth is at least a factor of ≈2 smaller than previously suggested. These much smaller effects strongly limit the applicability of the putative 184Os-180W system to investigate geological problems.

Root system of singular perturbations of the harmonic oscillator type operators

We analyze perturbations of the harmonic oscillator type operators in a Hilbert space H, i.e. of the self-adjoint operator with simple positive eigenvalues μ k satisfying μ k+1 − μ k ≥ Δ > 0. Perturbations are considered in the sense of quadratic forms. Under a local subordination assumption, the eigenvalues of the perturbed operator become eventually simple and the root system contains a Riesz basis.

Geochemistry of DSDP Leg 65 basalts

Leg 65 of the Deep Sea Drilling Project successfully recovered basalts from four sites in the mouth of the Gulf of California, thus completing a transect begun during Leg 64 from the continental margin of Baja California to the east side of the East Pacific Rise (EPR). Sixty-three whole-rock samples from Sites 482, 483, and 485 have been analyzed by X-ray fluorescence techniques, and a further eleven samples by instrumental neutron-activation techniques, in order to assess magma variability within and between sites. Although the major element compositions and absolute hygromagmatophile (HYG) element abundances are quite variable, all of the basalts are subalkaline tholeiites exhibiting strong more-HYG element (e.g., Rb, La, Nb, Ta) depletion (LaN/YbN ~ 0.4; Nb/Zr ~ 0.02; Ba/Zr ~ 0.23; Th/Hf ~ 0.05). These ratios, together with La/Ta ratios of 20 and Th/Ta ratios of 1.25, demonstrate that the Leg 65 basalts resemble the depleted "N-type" ocean ridge basalts recovered from the Mid-Atlantic Ridge (MAR) at 22 °N and other sections of the EPR. Zr/Ti, Zr/Y, and La/Yb ratios increase with increasing fractionation. It is clear that the basalts recovered from Sites 482, 483, and 485 were all derived from a compositionally similar source and that the compositional differences observed between lithological units can be explained by varying degrees of open system fractional crystallization (magma mixing) in subridge magma chambers. The basaltic rocks recovered from Site 474 near the margin of Baja California, and Sites 477, 478, and 481 in the Guaymas Basin, all drilled during Leg 64, have consistently higher Th/Hf, La/Sm, Zr/Ti, and Zr/Y ratios and higher absolute Sr contents than the Leg 65 basalts. While some of these variations may be explained by different conditions of partial melting, it is considered more likely that the mantle source underlying the Guaymas Basin is chemically distinct from that feeding the EPR at the mouth of the Gulf. These source variations probably reflect the complex tectonic setting of the Gulf of California, the magmas formed at the inception of spreading and in the central part of the Gulf containing a minor but significant component of sub-continental (calc-alkaline) material.

Chemical composition of surficial bottom sediments from the Chukchi Sea and adjacent part of the Arctic Ocean

This paper presents data on chemical composition of bottom sediments from the Chukchi Sea and the adjacent Arctic Ocean. Multivariate statistical techniques were used for analysis of the data set and revealed that grain size fractionation of the original terrigenous component during sedimentation was the major factor of clustering of the samples in study. Secondary factors include accumulation of biogenic siliceous and carbonate material and chemogenic or biochemical accumulation of iron, manganese, and some trace elements. The latter factor was significant in areas of tectonic activity within the graben-rift system of the Chukchi Sea.

Extended Triple-Junction Solar Cell 3D Distributed Model: Application to Chromatic Aberration-Related Losses

An extended 3D distributed model based on distributed circuit units for the simulation of triple‐junction solar cells under realistic conditions for the light distribution has been developed. A special emphasis has been put in the capability of the model to accurately account for current mismatch and chromatic aberration effects. This model has been validated, as shown by the good agreement between experimental and simulation results, for different light spot characteristics including spectral mismatch and irradiance non‐uniformities. This model is then used for the prediction of the performance of a triple‐junction solar cell for a light spot corresponding to a real optical architecture in order to illustrate its suitability in assisting concentrator system analysis and design process.

Estudio acústico y electroacústico de la sala 18 de Kinépolis (Madrid)

El objetivo de este proyecto se materializa en el diseño acústico y electroacústico de las salas de cine con número 18, 19, 20 y 21 del centro de cines Kinépolis situado en la Ciudad de la Imagen. Dichas salas son idénticas por lo que con el estudio y análisis de una se podrán extrapolar los resultados a las demás, por tanto a partir de ahora se realizará el diseño acústico y electroacústico centrado en la sala 18. Así pues se procederá a certificar que dicha sala cumple la norma THX. En dicho recinto se habrán aplicando con anterioridad diferentes técnicas de acondicionamiento sonoro (insonorización mediante el uso de materiales tanto absorbentes como reflectantes, arquitectura de la sala ), así como todos los acondicionamientos propios de un espacio de uso público cumpliendo las consiguientes normativas de seguridad. Se analizará la sala en su estado de partida mediante medidas acústicas in-situ tanto del tiempo de reverberación como del ruido de fondo, así como medidas espaciales con un medidor de alta precisión (láser); para posteriormente realizar las simulaciones en el programa EASE 4.01 de manera que la simulación sea lo más fidedigna posible. Estas medidas se realizarán de acuerdo a lo especificado en la norma UNE-EN ISO 3382. Cuando el comportamiento acústico del modelado de la sala sea el mismo que el de la sala real (respondan con el mismo Tiempo de Reverberación), mediante la introducción de los materiales adecuados y del ruido de fondo; se procederá al diseño electroacústico del equipo necesario para implementar el sistema de sonido multicanal Dolby (R). En el estudio electroacústico se distribuirán los diferentes altavoces que correctamente insertados ajustados sus niveles y retardos cubrirán con su señal uniformemente la sala cumpliendo los requisitos de la norma Dolby (R). Y finalmente una vez propuesto el sistema electroacústico y comprobado su correcto funcionamiento y por tanto el cumplimiento de la norma THX se propondrán mejoras en el sistema. Hay que señalar que aunque las recomendaciones THX son conocidas como norma THX no es una norma como tal, sino un conjunto de recomendaciones, que aconsejan utilizar una norma u otra para cada requisito. De ahora en adelante se referirá en este documento como norma THX. Se recuerda una vez más que dado que las salas son idénticas, y que las medidas realizadas en cada una de ellas son similares, se procederá en adelante al estudio de la sala única sala, la sala 18, siendo todos los estudios, análisis, comentarios y conclusiones aplicables a las otras 3 salas. Abstract The aim of this Project is the acoustic and electroacoustic design of the projection rooms 18th, 19th, 20th and 21st of the theater kinépolis, which is located at “Ciudad de la imagen”. These rooms are equal so with the studing and analazing of one of them , the results can be extrapolted from this one to the others, therefore as from now the and electroacoustic design will focus on the 18th room. As result the room will be certified that it comply with the standard THX. The starting point of the room will be analized such on-spot acoustical measures as the reverberation time and the noise level, in the same way the spatial measurements will be make with a precise laser meter, in order to perform simulations with the data obtained with the EASE 4.01 program. These mesurements should be made in accordance with the standard UNE-EN ISO 3382. Once the acoustical behavior of the simulated room became the same as the real room (the same reverberation times), through the configuration of the suitable materials and the background noise, previously measured, the electroacoustic design of the equipment necessary to develop the multichannel sound system Dolby (R) will be completed. In the electroacoustic design the sound power level and the dealys of the speakers and its amplifiers will be configurated till amplifiers provide an uniform coverage over the entire room in compliance with the Dolby (R) standard. Finally, once an electroacoustic system will be proposed and checked it works correctly in compliance with the THX standard, posible improvements will be identified. Abstract. Acoustic and electroacoustic study of the 18th room of the movie theater Kinépolis (Madrid) It must however be pointed out that although the THX standard is known as a standard it is actually a set of recommended practices made by Lucasfilm Ltd, anyway, from now on we will call it THX standard.

Understanding HCI policy in Spain in the context of acces

Spain pioneered policies related to disability and accessibility, especially in the physical environment. The first major piece of legislation was Act 13/1982 on the Social Integration of People with Disabilities. The law was published just a few years after the reinstitution of democracy in Spain in 1977 and the approval of the Spanish Constitution in 1978. Act 13/1982 is a general law that applies accessibility to social services and education, as well as to workplace and physical accessibility. This law targeted first and foremost the social integration of people with disabilities, and it was a significant success, especially in the field of employment, as it made it mandatory for private companies and public administrations to employ a certain percentage of persons with disabilities. This greatly increased the employability of people with disabilities, as highlighted in a document celebrating 30 years of Act 13/1982. Over the past 20 years, policy makers have also focused on accessibility to information and communication technologies (ICT), developing first the national computing accessibility standards and then specialized legislation. Initially, Spanish activities were mostly national but have now gained an international dimension. All these initiatives are strongly related to the discipline of human-computer interaction, as the key component of an accessible system is its user interface.

Optics detailed analysis of an improved collimation system for LED light sources

Optics detailed analysis of an improved collimation system for LED light sources

Sistema de información geográfica Campus Sur UPM

El proyecto que he realizado ha consistido en la creación de un sistema de información geográfica para el Campus Sur UPM, que puede servir de referencia para su implantación en cualquier otro campus universitario. Esta idea surge de la necesidad por parte de los usuarios de un campus de disponer de una herramienta que les permita consultar la información de los distintos lugares y servicios del campus, haciendo especial hincapié en su localización geográfica. Para ello ha sido necesario estudiar las tecnologías actuales que permiten implementar un sistema de información geográfica, dando lugar al sistema propuesto, que consiste en un conjunto de medios informáticos (hardware y software), que van a permitir al personal del campus obtener la información y localización de los elementos del campus desde su móvil. Tras realizar un análisis de los requisitos y funcionalidades que debía tener el sistema, el proyecto ha consistido en el diseño e implementación de dicho sistema. La información a consultar estará almacenada y disponible para su consulta en un equipo servidor accesible para el personal del campus. Para ello, durante la realización del proyecto, ha sido necesario crear un modelo de datos basado en el campus y cargar los datos geográficos de utilidad en una base de datos. Todo esto ha sido realizado mediante el producto software Smallword Core 4.2. Además, ha sido también necesario desplegar un software servidor que permita a los usuarios consultar dichos datos desde sus móviles vía WIFI o Internet, el producto utilizado para este fin ha sido Smallworld Geospatial Server 4.2. Para la realización de las consultas se han utilizado los servicios WMS(Web Map Service) y WFS(Web Feature Service) definidos por el OGC(Open Geospatial Consortium). Estos servicios están adaptados para la consulta de información geográfica. El sistema también está compuesto por una aplicación para dispositivos móviles con sistema operativo Android, que permite a los usuarios del sistema consultar y visualizar la información geográfica del campus. Dicha aplicación ha sido diseñada y programada a lo largo de la realización del proyecto. Para la realización de este proyecto también ha sido necesario un estudio del presupuesto que supondría una implantación real del sistema y el mantenimiento que implicaría tener el sistema actualizado. Por último, el proyecto incluye una breve descripción de las tecnologías futuras que podrían mejorar las funcionalidades del sistema: la realidad aumentada y el posicionamiento en el interior de edificios. ABSTRACT. The project I've done has been to create a geographic information system for the Campus Sur UPM, which can serve as a reference for implementation in any other college campus. This idea arises from the need for the campus users to have a tool that allows them to view information from different places and services, with particular emphasis on their geographical location. It has been necessary to study the current technologies that allow implementing a geographic information system, leading to the proposed system, which consists of a set of computer resources (hardware and software) that will allow campus users to obtain information and location of campus components from their mobile phones. Following an analysis of the requirements and functionalities that the system should have, the project involved the design and implementation of the system . The information will be stored and available on a computer server accessible to campus users. Accordingly, during the project, it was necessary to create a data model based on campus data and load this data in a database. All this has been done by Smallword Core 4.2 software product. In addition, it has also been necessary to deploy a server software that allows users to query the data from their phones via WIFI or Internet, the product used for this purpose has been Smallworld Geospatial Server 4.2 . To carry out the consultations have used the services WMS (Web Map Service) and WFS (Web Feature Service) defined by the OGC (Open Geospatial Consortium). These services are tailored to the geographic information retrieval. The system also consists of an application for mobile devices with Android operating system, which allows users to query and display geographic information related to the campus. This application has been designed and programmed over the project. For the realization of this project has also been necessary to study the budget that would be a real system implementation and the maintenance that would have the system updated. Finally, the project includes a brief description of future technologies that could improve the system's functionality: augmented reality and positioning inside the buildings.

Open Technologies for prototyping the Internet of Things

The worldwide "hyper-connection" of any object around us is the challenge that promises to cover the paradigm of the Internet of Things. If the Internet has colonized the daily life of more than 2000 million1 people around the globe, the Internet of Things faces of connecting more than 100000 million2 "things" by 2020. The underlying Internet of Things’ technologies are the cornerstone that promises to solve interrelated global problems such as exponential population growth, energy management in cities, and environmental sustainability in the average and long term. On the one hand, this Project has the goal of knowledge acquisition about prototyping technologies available in the market for the Internet of Things. On the other hand, the Project focuses on the development of a system for devices management within a Wireless Sensor and Actuator Network to offer some services accessible from the Internet. To accomplish the objectives, the Project will begin with a detailed analysis of various “open source” hardware platforms to encourage creative development of applications, and automatically extract information from the environment around them for transmission to external systems. In addition, web platforms that enable mass storage with the philosophy of the Internet of Things will be studied. The project will culminate in the proposal and specification of a service-oriented software architecture for embedded systems that allows communication between devices on the network, and the data transmission to external systems. Furthermore, it abstracts the complexities of hardware to application developers. RESUMEN. La “hiper-conexión” a nivel mundial de cualquier objeto que nos rodea es el desafío al que promete dar cobertura el paradigma de la Internet de las Cosas. Si la Internet ha colonizado el día a día de más de 2000 millones1 de personas en todo el planeta, la Internet de las Cosas plantea el reto de conectar a más de 100000 millones2 de “cosas” para el año 2020. Las tecnologías subyacentes de la Internet de las Cosas son la piedra angular que prometen dar solución a problemas globales interrelacionados como el crecimiento exponencial de la población, la gestión de la energía en las ciudades o la sostenibilidad del medioambiente a largo plazo. Este Proyecto Fin de Carrera tiene como principales objetivos por un lado, la adquisición de conocimientos acerca de las tecnologías para prototipos disponibles en el mercado para la Internet de las Cosas, y por otro lado el desarrollo de un sistema para la gestión de dispositivos de una red inalámbrica de sensores que ofrezcan unos servicios accesibles desde la Internet. Con el fin de abordar los objetivos marcados, el proyecto comenzará con un análisis detallado de varias plataformas hardware de tipo “open source” que estimulen el desarrollo creativo de aplicaciones y que permitan extraer de forma automática información del medio que les rodea para transmitirlo a sistemas externos para su posterior procesamiento. Por otro lado, se estudiarán plataformas web identificadas con la filosofía de la Internet de las Cosas que permitan el almacenamiento masivo de datos que diferentes plataformas hardware transfieren a través de la Internet. El Proyecto culminará con la propuesta y la especificación una arquitectura software orientada a servicios para sistemas empotrados que permita la comunicación entre los dispositivos de la red y la transmisión de datos a sistemas externos, así como facilitar el desarrollo de aplicaciones a los programadores mediante la abstracción de la complejidad del hardware.