988 resultados para Teerk Roo Ra


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The SuperWASP-I (Wide Angle Search for Planets-I) instrument observed 6.7 million stars between 8 and 15mag from La Palma during the 2004 May-September season. Our transit-hunting algorithm selected 11626 objects from the 184442 stars within the RA (right ascension) range 18-21h. We describe our thorough selection procedure whereby catalogue information is exploited along with careful study of the SuperWASP data to filter out, as far as possible, transit mimics. We have identified 35 candidates which we recommend for follow-up observations.

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The Wide Angle Search for Planets (WASP) photometrically surveys a large number of nearby stars to uncover candidate extrasolar planet systems by virtue of small-amplitude light curve dips on a

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BACKGROUND: Patients with castration-resistant prostate cancer (CRPC) and bone metastases have an unmet clinical need for effective treatments that improve quality of life and survival with a favorable safety profile. OBJECTIVE: To prospectively evaluate the efficacy and safety of three different doses of radium chloride (Ra 223) in patients with CRPC and bone metastases. DESIGN, SETTING, AND PARTICIPANTS: In this phase 2 double-blind multicenter study, 122 patients were randomized to receive three injections of Ra 223 at 6-wk intervals, at doses of 25 kBq/kg (n=41), 50 kBq/kg (n=39), or 80 kBq/kg (n=42). The study compared the proportion of patients in each dose group who had a confirmed decrease of =50% in baseline prostate-specific antigen (PSA) levels. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Efficacy was evaluated using blood samples to measure PSA and other tumor markers, recorded skeletal-related events, and pain assessments. Safety was evaluated using adverse events (AEs), physical examination, and clinical laboratory tests. The Jonckheere-Terpstra test assessed trends between groups. RESULTS AND LIMITATIONS: The study met its primary end point with a statistically significant dose-response relationship in confirmed =50% PSA declines for no patients (0%) in the 25-kBq/kg dose group, two patients (6%) in the 50-kBq/kg dose group, and five patients (13%) in the 80-kBq/kg dose group (p=0.0297). A =50% decrease in bone alkaline phosphatase levels was identified in six patients (16%), 24 patients (67%), and 25 patients (66%) in the 25-, 50-, and 80-kBq/kg dose groups, respectively (p

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Osseous metastases are a source of significant morbidity for patients with a variety of cancers. Radiotherapy is well established as an effective means of palliating symptoms associated with such metastases. The role of external beam radiotherapy is limited where sites of metastases are numerous and widespread. Low linear energy transfer (LET) radionuclides have been utilized to allow targeted delivery of radiotherapy to disparate sites of disease, with evidence of palliative benefit. More recently, the bone targeting, high LET radionuclide (223)Ra has been shown to not only have a palliative effect but also a survival prolonging effect in metastatic, castration-resistant prostate cancer with bone metastases. This article reviews the different radionuclide-based approaches for targeting bone metastases, with an emphasis on (223)Ra, and key elements of the underlying radiobiology of these that will impact their clinical effectiveness. Consideration is given to the remaining unknowns of both the basic radiobiological and applied clinical effects of (223)Ra as targets for future research.

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Das deutsche Bildungssystem - Hochschulen und Schulen - befindet sich seit Beginn der 90er Jahre des 20. Jahrhunderts in einem von den ökonomischen und politischen Eliten gewollten Transformationsprozess. Das bisher staatliche Hochschulsystem verliert dabei schrittweise seinen Charakter als öffentliches Gut und entwickelt sich hin zu einem formell halbstaatlichen Teilsystem unter indirekter Kontrolle der privaten Wirtschaft. Für diese Umgestaltung wird es nach dem Vorbild der privaten Wettbewerbswirtschaft reorganisiert, ökonomisch rationalisiert und technokratisch gesteuert. Zugleich wird es einer internen Partizipation wie einer externen parlamentarischen Kontrolle entzogen.

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Tese de Doutoramento, Ciências do Mar (Ecologia Marinha), 26 de Novembro de 2013, Universidade dos Açores.

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[Hymne à Amon (français). 1870]

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Tesis (Maestría en Ciencias Biológicas con Especialidad en Entomología Médica) UANL.

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UANL

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Tesis (Doctorado en Ciencias con Acentuación en Entomología Médica) UANL, 2013.