Die Bevolkerungsdichte in Sudhannover und deren Ursachen : mit einer Karte (1:300 000) und einem Querprofil durch das Leinethal bei Gottingen (1:200 000).

Thesis (doctoral)--Georg-Augusts Universitat zu Gottingen.

AWI Bathymetric Chart of the Gakkel Ridge (AWI BCGR) (Scale 1:150,000)

The 1 : 1,500,000 AWI Bathymetric Chart of the Gakkel Ridge (AWI BCGR) has been developed from multibeam data measured during the Arctic Mid-Ocean Ridge Expedition in 2001 (AMORE 2001, ARK-XVII/2). This expedition was conducted to investigate the Gakkel Ridge in the Arctic Ocean and was carried out by the icebreaking research vessels RV Polarstern and USCGC Healy. Polarstern is equipped with the multibeam sonar system Hydrosweep DS-2, whereas Healy carries Seabeam 2112. During the expedition an area of 8890 km length and 18 - 46 km width, situated between 82°N/8°W and 87°N/75°E, was surveyed simultaneously by both vessels. Water depths ranged from 566 to 5673 meters. Dense sea ice cover derogated the sonar measurements and decreased data quality. Data errors were corrected in an extensive post-processing. The data of two different sonar systems had to be consolidated in order to derive a high resolution bathymetry of the Gakkel Ridge. Final result was a digital terrain model (DTM) with a grid spacing of 100 meters, which was utilized for generating the map series AWI Bathymetric Chart of the Gakkel Ridge, consisting of ten map sheets.

Proposed Boston Harbor Islands National Recreation Area

produced by the Metropolitan Area Planning Council GIS Lab.

Naval Air Station South Weymouth reuse study: Rockland land use

Shows land use in the part of Rockland adjoining South Weymouth Naval Air Station.

Palestine ancienne & moderne d'après les sources les plus authentiques

par E. Andriveau ; gravé le trait et les montagnes par Gérin, les écritures par P. Rousset, les eaux par Mme Fontaine.

Karte des Bosporus und der Bithynischen Halbinsel

nach älteren Quellen (v. Moltke, Heinrich Kiepert, Brit. Admiralitätskarten, v. d. Goltz, v. Diest u.a.) und eigenen Aufnahmen im Jahre 1900 gezeichnet von Rudolf Fitzner ; Hof. Stdr. v. J. G. Tiedmann Nachf.

Prof. C. Haussknecht's Routen im Orient 1865-1869: III. Kurdistan und Irak

nach dessen Originalskizzen redigirt von H. Kiepert.

Central Africa: on a scale of 1:10,000,000

by Dr. F. Boas.

Vienna, Austria, 1770 (Image 1 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Grund Riss der Ka�. K�ningl. residenz stadt Wien unter glorw�rdigster Regierung be�der ma�ten. Josephs des IIten. R�m. Ka�sers un Mari� Theresi� R�m. Ka�serin und Apost. K�nigin auf allerh�chsten Befehl, unter der Direction dero hof Mathematici Joseph Nagel aufgenommen von den N.�. Reg.Ingenieur Franz Gruss und Joseph Ne�ssner ; J.E. Mansfeld Sculp. It was published in 1770. Scale [ca. 1:1,300]. Covers Vienna, Austria. This layer is image 1 of 4 total images, representing the southeast portion of the four sheet source map. Map in German. The image inside the map neatline is georeferenced to the surface of the earth and fit to the MGI 3-Degree Gauss Kruger coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map.This map shows features such as roads, drainage, built-up areas and selected buildings, fortification and more.This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Rock map of the Yellow River (Huang He) expedition, China, 1925-1927 : Sheet 1

This layer is part of a set of georeferenced, raster images of the manuscript, paper map set entitled: Ch'ing-Hai upper Yellow River expedition : Rock and Simpson, 1925-27, [cartography by J.F. Rock]. Scale 1:250,000. This layer image is of Sheet I [of 10] covering a portion of the Yellow River (Huang He) region in eastern Qinghai Sheng, China. The map set details the route and surrounding environs of the Arnold Arboretum's "Western China" expedition led by Joseph Rock, 1924-1927. The set covers a portion of the Yellow River (Huang He) region in south central China (Qinghai, Gansu, and Sichuan shengs (a portion of historic Tibet)). It shows features, labeled variously in English, Chinese, Wade-Giles transliteration, and Tibetan, including: rivers, streams, lakes, mountains, gorges, valleys, plateaus, plains, cities, towns, villages, provincial capitals, county seats, passes, monasteries, ruin sites, native tribe locations, and more. Relief is shown by hachures, spot heights, and landform drawings. The original manuscript map set is part of the Harvard College Library, Harvard Map Collection. "Joseph Rock traced his travels for the [Arnold] Arboretum's [Western China] 1924-1927 expedition in a colorful, hand-drawn map entitled 'Ch'ing-Hai upper Yellow River expedition.' The pen-and-ink drawing was made on ten sheets that when joined form a single, irregularly-shaped map, approximately six by eight feet in size. The individual sheets are numbered, using roman numerals; on sheet VII is a second title, 'Choni Territory, Upper and Lower T'ieh-Pu country and route to Sung-Pan, J. F. Rock, 1925-1927.' Topographical and other features are identified using a combination of English, Chinese characters, Wade-Giles transliterations and Tibetan script. Rock's attractive cursive style and use of hachures, spot heights, and landform drawings to depict relief add character to the map." -- Text from the Arnold Arboretum Web site.

Mapping glider habitat in dry eucalypt forests for Montreal Process indicator 1.1: Fragmentation of forest types

Accurate habitat mapping is critical to landscape ecological studies such as required for developing and testing Montreal Process indicator 1.1e, fragmentation of forest types. This task poses a major challenge to remote sensing, especially in mixedspecies, variable-age forests such as dry eucalypt forests of subtropical eastern Australia. In this paper, we apply an innovative approach that uses a small section of one-metre resolution airborne data to calibrate a moderate spatial resolution model (30 m resolution; scale 1:50 000) based on Landsat Thematic Mapper data to estimate canopy structural properties in St Marys State Forest, near Maryborough, south-eastern Queensland. The approach applies an image-processing model that assumes each image pixel is significantly larger than individual tree crowns and gaps to estimate crown-cover percentage, stem density and mean crown diameter. These parameters were classified into three discrete habitat classes to match the ecology of four exudivorous arboreal species (yellowbellied glider Petaurus australis, sugar glider P. breviceps, squirrel glider P. norfolcensis , and feathertail glider Acrobates pygmaeus), and one folivorous arboreal marsupial, the greater glider Petauroides volans. These species were targeted due to the known ecological preference for old trees with hollows, and differences in their home range requirements. The overall mapping accuracy, visually assessed against transects (n = 93) interpreted from a digital orthophoto and validated in the field, was 79% (KHAT statistic = 0.72). The KHAT statistic serves as an indicator of the extent that the percentage correct values of the error matrix are due to ‘true’ agreement verses ‘chance’ agreement. This means that we are able to reliably report on the effect of habitat loss on target species, especially those with a large home range size (e.g. yellow-bellied glider). However, the classified habitat map failed to accurately capture the spatial patterning (e.g. patch size and shape) of stands with a trace or sub-dominance of senescent trees. This outcome makes the reporting of the effects of habitat fragmentation more problematic, especially for species with a small home range size (e.g. feathertail glider). With further model refinement and validation, however, this moderateresolution approach offers an important, cost eff e c t i v e advancement in mapping the age of dry eucalypt forests in the region.

O retrato da integração das TIC no 1º ciclo: Que perspectivas?

Durante a última década fizeram-se diversos investimentos que impulsionaram mudanças no apetrechamento de equipamento informático nas escolas e na formação de professores. Parece-nos haver necessidade de entender em que estádio de desenvolvimento se encontram os professores no âmbito das TIC, que tipo de ferramentas utilizam, com que frequência e que resultados verificam nas práticas pedagógicas. Esta investigação envolveu cerca de 1300 professores a leccionarem em escolas públicas e privadas na região do grande Porto e tem como propósito reflectir sobre a integração das TIC na educação podendo contribuir no apoio à decisão em futuras iniciativas.

Diffusion-weighted MR imaging of the spine at 3-T: feasibility, optimization of b-value and utility to differentiate benign from pathological vertebral compression fractures

Purpose: To evaluate the feasibility, determine the optimal b-value, and assess the utility of 3-T diffusion-weighted MR imaging (DWI) of the spine in differentiating benign from pathologic vertebral compression fractures.Methods and Materials: Twenty patients with 38 vertebral compression fractures (24 benign, 14 pathologic) and 20 controls (total: 23 men, 17 women, mean age 56.2years) were included from December 2010 to May 2011 in this IRB-approved prospective study. MR imaging of the spine was performed on a 3-T unit with T1-w, fat-suppressed T2-w, gadolinium-enhanced fat-suppressed T1-w and zoomed-EPI (2D RF excitation pulse combined with reduced field-of-view single-shot echo-planar readout) diffusion-w (b-values: 0, 300, 500 and 700s/mm2) sequences. Two radiologists independently assessed zoomed-EPI image quality in random order using a 4-point scale: 1=excellent to 4=poor. They subsequently measured apparent diffusion coefficients (ADCs) in normal vertebral bodies and compression fractures, in consensus.Results: Lower b-values correlated with better image quality scores, with significant differences between b=300 (mean±SD=2.6±0.8), b=500 (3.0±0.7) and b=700 (3.6±0.6) (all p<0.001). Mean ADCs of normal vertebral bodies (n=162) were 0.23, 0.17 and 0.11×10-3mm2/s with b=300, 500 and 700s/mm2, respectively. In contrast, mean ADCs were 0.89, 0.70 and 0.59×10-3mm2/s for benign vertebral compression fractures and 0.79, 0.66 and 0.51×10-3mm2/s for pathologic fractures with b=300, 500 and 700s/mm2, respectively. No significant difference was found between ADCs of benign and pathologic fractures.Conclusion: 3-T DWI of the spine is feasible and lower b-values (300s/mm2) are recommended. However, our preliminary results show no advantage of DWI in differentiating benign from pathologic vertebral compression fractures.

Induction of protective T-helper 1 immune responses against Echinococcus granulosus in mice by a multi-T-cell epitope antigen based on five proteins

In this study, we designed an experiment to predict a potential immunodominant T-cell epitope and evaluate the protectivity of this antigen in immunised mice. The T-cell epitopes of the candidate proteins (EgGST, EgA31, Eg95, EgTrp and P14-3-3) were detected using available web-based databases. The synthesised DNA was subcloned into the pET41a+ vector and expressed in Escherichia coli as a fusion to glutathione-S-transferase protein (GST). The resulting chimeric protein was then purified by affinity chromatography. Twenty female C57BL/6 mice were immunised with the antigen emulsified in Freund's adjuvant. Mouse splenocytes were then cultured in Dulbecco's Modified Eagle's Medium in the presence of the antigen. The production of interferon-γ was significantly higher in the immunised mice than in the control mice (> 1,300 pg/mL), but interleukin (IL)-10 and IL-4 production was not statistically different between the two groups. In a challenge study in which mice were infected with 500 live protoscolices, a high protectivity level (99.6%) was demonstrated in immunised BALB/C mice compared to the findings in the control groups [GST and adjuvant (Adj) ]. These results demonstrate the successful application of the predicted T-cell epitope in designing a vaccine against Echinococcus granulosus in a mouse model.

Simultaneous determination of antidementia drugs by HPLC-MS: validation data of the method and plasma level determinations in 300 patients

Aims: A rapid and simple HPLC-MS method was developed for the simultaneousdetermination of antidementia drugs, including donepezil, galantamine, rivastigmineand its major metabolite NAP 226 - 90, and memantine, for TherapeuticDrug Monitoring (TDM). In the elderly population treated with antidementiadrugs, the presence of several comorbidities, drug interactions resulting frompolypharmacy, and variations in drug metabolism and elimination, are possiblefactors leading to the observed high interindividual variability in plasma levels.Although evidence for the benefit of TDM for antidementia drugs still remains tobe demonstrated, an individually adapted dosage through TDM might contributeto minimize the risk of adverse reactions and to increase the probability of efficienttherapeutic response. Methods: A solid-phase extraction procedure with amixed-mode cation exchange sorbent was used to isolate the drugs from 0.5 mL ofplasma. The compounds were analyzed on a reverse-phase column with a gradientelution consisting of an ammonium acetate buffer at pH 9.3 and acetonitrile anddetected by mass spectrometry in the single ion monitoring mode. Isotope-labeledinternal standards were used for quantification where possible. The validatedmethod was used to measure the plasma levels of antidementia drugs in 300patients treated with these drugs. Results: The method was validated accordingto international standards of validation, including the assessment of the trueness(-8 - 11 %), the imprecision (repeatability: 1-5%, intermediate imprecision:2 - 9 %), selectivity and matrix effects variability (less than 6 %). Furthermore,short and long-term stability of the analytes in plasma was ascertained. Themethod proved to be robust in the calibrated ranges of 1 - 300 ng/mL for rivastigmineand memantine and 2 - 300 mg/mL for donepezil, galantamine and NAP226 - 90. We recently published a full description of the method (1). We found ahigh interindividual variability in plasma levels of these drugs in a study populationof 300 patients. The plasma level measurements, with some preliminaryclinical and pharmacogenetic results, will be presented. Conclusion: A simpleLC-MS method was developed for plasma level determination of antidementiadrugs which was successfully used in a clinical study with 300 patients.