Lola and George Gruenthal in Neu-Ulm Portraits Family

"When will you come back?" (written in German on verso)

George Gruenthal as a child Portraits Children

Son of Max and Lola Gruenthal

Portrait of George Louis Wolff (Gerd Ludwig Wolff) holding a mouse in his genetics laboratory; Little Rock, Arkansas.

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Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Dorothea (Dola) Guttmann Gould; Jerusalem Portraits Women

Born April 27, 1922 in Tilsit, died June 8, 2003 Zurich; Married to Henry H. Goldschmidt Gould August 7, 1960 in Montreal

Dorothea (Dola) Guttmann Gould speaking at American Express stockholders meeting Portraits Women

This photograph was included in the meeting's published report

Henry H. Goldschmidt Gould (seated on right) with unidentified young men and women; Neue Welt Bockbierfest Portraits Groups

Born July 15, 1914, died August 6, 1978

Henry H. Goldschmidt Gould; Berlin Portraits Groups

Born July 15, 1914, died August 6, 1978

Henry H. Goldschmidt Gould standing outdoors Portraits Children

Born July 15, 1914, died August 6, 1978

Henry H. Goldschmidt Gould (top row fourth from right) with unidentified school classmates Portraits Children

Born July 15, 1914, died August 6, 1978

Contact sheet of portraits of George Victor Wolff Portraits; Men

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Portrait of George Louis Wolff (Gerd Ludwig Wolff) holding a mouse in his genetics laboratory; Little Rock, Arkansas.

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