129 resultados para Reorganisation


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Nachdem sich in der Kolonialkrise von 1906 das Scheitern der ersten Periode deutscher Kolonialherrschaft (1885-1906) offenbarte, wurde Bernhard Dernburg die grundlegende Reorganisation der Kolonialpolitik anvertraut. Als Mann aus der Welt der Banken und Finanzen sollte er die stagnierende Entwicklung der Kolonien mit Hilfe von administrativen und wirtschaftlichen Reformmaßnahmen vorantreiben und gleichzeitig der indigenen Bevölkerung eine humane Behandlung zu garantieren. Um diese Ziele zu erreichen, verabschiedete er Reformen, die eine Rationalisierung und Humanisierung der Arbeiterpolitik vorsahen. Sowohl in der zeitgenössischen Literatur als auch in der aktuellen wissenschaftlichen Forschung wird der Amtsantritt Bernhard Dernburgs zum Leiter der Kolonialabteilung im Jahre 1906 als der „Beginn einer neuen humanen Ära“ deutscher Kolonialpolitik oder als „Wandel zum Besseren“ bezeichnet. Die Dissertation „Schwarzer Untertan versus Schwarzer Bruder. Bernhard Dernburgs Reformen in den Kolonien Deutsch-Ostafrika, Deutsch-Südwestafrika, Togo und Kamerun“ untersucht die Intention, Akzeptanz, Umsetzung und Auswirkung der reformatorischen Eingeborenenpolitik und klärt, ob die Beurteilung der Ära Dernburg (1906-1910) in der zeitgenössischen und aktuellen Forschung eine Berechtigung hat. Obwohl zumindest in der Theorie sein Konzept einer rationalen und humanen Kolonialpolitik sicherlich eine Abkehr von der bisher betriebenen Kolonialpolitik bedeutete, zeigt sich jedoch bei der Umsetzung der Reformen eine deutliche Diskrepanz zwischen Intention und Realität. Auch wenn zumindest die Bestrebung Dernburgs zur Verrechtlichung der indigenen Arbeitsverhältnisse gewürdigt werden sollte, so muss doch konstatiert werden, dass es in der „Ära Dernburg“ definitiv nicht zu einer grundlegenden Verbesserung der indigenen Lebenssituation in den deutschen Kolonien kam. Im Gegenteil, die Dernburgsche Reformpolitik beschleunigte vielmehr den Verelendungsprozess der indigenen Bevölkerung. In allen afrikanischen Kolonien verschlechterten sich mit der Intensivierung der Verwaltung die sozialen und menschlichen Beziehungen zwischen Afrikanern und Europäern. Vieles von dem, was Dernburg in seinem Programm propagierte, konnte nicht erreicht werden. Zwar führte Dernburg in Deutsch-Ostafrika, Deutsch-Südwestafrika und in Kamerun eine rechtlich bindende Arbeiterverordnung ein, jedoch unterschieden sich die Bestimmungen zum Teil erheblich voneinander, so dass von einer einheitlichen Modernisierung des kolonialen Arbeitsrechts nicht die Rede sein kann. Viele arbeitsrechtliche Bereiche, wie z.B. die Arbeiteranwerbung, Lohnzahlung, Minderjährigenschutz, Vertragsdauer, Arbeitszeit, Verpflegung und Unterkunft wurden nur unzureichend geregelt. Ähnlich negativ muss auch die Reformierung der Strafrechtspflege bewertet werden. Die Kodifizierung eines Eingeborenenstrafrechts scheiterte sowohl am Widerstand der lokalen Verwaltung als auch am Grundkonsens der Rechtmäßigkeit einer Rassenjustiz. Kolonialpolitik war auch in der „Ära Dernburg“ nichts anderes als „rohe Ausbeutungspolitik“, die zur Lösung der Arbeiterfrage beitragen sollte. Aber gerade hier, bei der Mobilisierung von afrikanischen Lohnarbeitern, war der Kolonialstaatssekretär nicht etwa mit einer „Arbeiterfürsorgepolitik“, sondern mit der Fortführung der Enteignungs- und Zwangsmaßnahmen erfolgreich gewesen. Insgesamt ist ein deutlicher Anstieg an afrikanischen Arbeitern in europäischen Unternehmen zu verzeichnen, was darauf schließen lässt, dass Dernburgs Verordnungen einen günstigen Einfluss auf die Arbeiterfrage ausgeübt haben. Obwohl nicht von einem grundlegenden Neuanfang der Kolonialpolitik gesprochen werden kann, sollte ebenso wenig bezweifelt werden, dass sich die deutsche Kolonialpolitik nicht unter Dernburg veränderte. Größere indigene Aufstände und Unruhen blieben aus, so dass während seiner Amtszeit eine systematische wirtschaftliche Erschließung der Kolonien beginnen konnte.

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Natural resource-dependent societies in developing countries are facing increased pressures linked to global climate change. While social-ecological systems evolve to accommodate variability, there is growing evidence that changes in drought, storm and flood extremes are increasing exposure of currently vulnerable populations. In many countries in Africa, these pressures are compounded by disruption to institutions and variability in livelihoods and income. The interactions of both rapid and slow onset livelihood disturbance contribute to enduring poverty and slow processes of rural livelihood renewal across a complex landscape. We explore cross-scale dynamics in coping and adaptation response, drawing on qualitative data from a case study in Mozambique. The research characterises the engagements across multiple institutional scales and the types of agents involved, providing insight into emergent conditions for adaptation to climate change in rural economies, The analysis explores local responses to climate shocks, food security and poverty reduction, through informal institutions, forms of livelihood diversification and collective land-use systems that allow reciprocity, flexibility and the ability to buffer shocks. However, the analysis shows that agricultural initiatives have helped to facilitate effective livelihood renewal, through the reorganisation of social institutions and opportunities for communication, innovation and micro-credit. Although there are challenges to mainstreaming adaptation at different scales, this research shows why it is critical to assess how policies can protect conditions for emergence of livelihood transformation. (C) 2008 Elsevier Ltd. All rights reserved.

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It has been asserted that business reorganisation and new working practices are transforming the nature of demand for business space. Downsizing, delayering, business process reengineering and associated initiatives alter the amount, type and location of space required by firms. The literature has neglected the impact of real estate market structures on the ability of organisations to successfully implement these new organisational forms or contemporary working practices. Drawing from UK research, the paper demonstrates that, while new working practices are widespread, their impact on the corporate real estate portfolio is less dramatic than often supposed. In part, this is attributed to inflexibility in market structures which constrains the supply of appropriate space.

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X-ray Rheology is an experimental technique which uses time-ressolved x-ray scattering as probe of the molecular level structural reorganisation which accompanies flow. It provides quantitative information on the direction alignment and on the level of global orientation. This information is very helpful in interpreting the classic rheological data on liquid crystal polymers. In this research we use data obtained from a cellulose derivate which exhibits a thermotropic liquid crystal phase. We show how increased shear rates lead to a rapid rise in the global orientation and we related this to therories of flow in liquid crystal polymers from the literature. We show that the relaxation time is independent of the prior shear rate.

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We present a new speleothem record of atmospheric Δ14C between 28 and 44 ka that offers considerable promise for resolving some of the uncertainty associated with existing radiocarbon calibration curves for this time period. The record is based on a comprehensive suite of AMS 14C ages, using new low-blank protocols, and U–Th ages using high precision MC-ICPMS procedures. Atmospheric Δ14C was calculated by correcting 14C ages with a constant dead carbon fraction (DCF) of 22.7 ± 5.9%, based on a comparison of stalagmite 14C ages with the IntCal04 (Reimer et al., 2004) calibration curve between 15 and 11 ka. The new Δ14C speleothem record shows similar structure and amplitude to that derived from Cariaco Basin foraminifera (Hughen et al., 2004, 2006), and the match is further improved if the latter is tied to the most recent Greenland ice core chronology (Svensson et al., 2008). These data are however in conflict with a previously published 14C data set for a stalagmite record from the Bahamas — GB-89-24-1 (Beck et al., 2001), which likely suffered from 14C analytical blank subtraction issues in the older part of the record. The new Bahamas speleothem ∆14C data do not show the extreme shifts between 44 and 40 ka reported in the previous study (Beck et al., 2001). Causes for the observed structure in derived atmospheric Δ14C variation based on the new speleothem data are investigated with a suite of simulations using an earth system model of intermediate complexity. Data-model comparison indicates that major fluctuations in atmospheric ∆14C during marine isotope stage 3 is primarily a function of changes in geomagnetic field intensity, although ocean–atmosphere system reorganisation also played a supporting role.

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On 14 January 2001, the four Cluster spacecraft passed through the northern magnetospheric mantle in close conjunction to the EISCAT Svalbard Radar (ESR) and approached the post-noon dayside magnetopause over Greenland between 13:00 and 14:00 UT During that interval, a sudden reorganisation of the high-latitude dayside convection pattern accurred after 13:20 UT most likely caused by a direction change of the Solar wind magnetic field. The result was an eastward and poleward directed flow-channel, as monitored by the SuperDARN radar network and also by arrays of ground-based magnetometers in Canada, Greenland and Scandinavia. After an initial eastward and later poleward expansion of the flow-channel between 13:20 and 13:40 UT, the four Cluster spacecraft, and the field line footprints covered by the eastward looking scan cycle of the Sondre Stromfjord incoherent scatter radar were engulfed by cusp-like precipitation with transient magnetic and electric field signatures. In addition, the EISCAT Svalbard Radar detected strong transient effects of the convection reorganisation, a poleward moving precipitation, and a fast ion flow-channel in association with the auroral structures that suddenly formed to the west and north of the radar. From a detailed analysis of the coordinated Cluster and ground-based data, it was found that this extraordinary transient convection pattern, indeed, had moved the cusp precipitation from its former pre-noon position into the late post-noon sector, allowing for the first and quite unexpected encounter of the cusp by the Cluster spacecraft. Our findings illustrate the large amplitude of cusp dynamics even in response to moderate solar wind forcing. The global ground-based data proves to be an invaluable tool to monitor the dynamics and width of the affected magnetospheric regions.

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Adaptive governance is the use of novel approaches within policy to support experimentation and learning. Social learning reflects the engagement of interdependent stakeholders within this learning. Much attention has focused on these concepts as a solution for resilience in governing institutions in an uncertain climate; resilience representing the ability of a system to absorb shock and to retain its function and form through reorganisation. However, there are still many questions to how these concepts enable resilience, particularly in vulnerable, developing contexts. A case study from Uganda presents how these concepts promote resilient livelihood outcomes among rural subsistence farmers within a decentralised governing framework. This approach has the potential to highlight the dynamics and characteristics of a governance system which may manage change. The paper draws from the enabling characteristics of adaptive governance, including lower scale dynamics of bonding and bridging ties and strong leadership. Central to these processes were learning platforms promoting knowledge transfer leading to improved self-efficacy, innovation and livelihood skills. However even though aspects of adaptive governance were identified as contributing to resilience in livelihoods, some barriers were identified. Reflexivity and multi-stakeholder collaboration were evident in governing institutions; however, limited self-organisation and vertical communication demonstrated few opportunities for shifts in governance, which was severely challenged by inequity, politicisation and elite capture. The paper concludes by outlining implications for climate adaptation policy through promoting the importance of mainstreaming adaptation alongside existing policy trajectories; highlighting the significance of collaborative spaces for stakeholders and the tackling of inequality and corruption.

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The effects of verapamil modulating collagen biosynthesis have prompted us to study the role of this drug in cultured fibroblasts. In this article, we describe the effects of verapamil on fibroblast behaviour, with special emphasis to phenotypic modifications, reorganisation of actin filaments and secretion of MMP1. Human dermal fibroblasts treated with 50-mu M verapamil changed their normal spindle-shaped morphology to stellate. Treated cells showed discrete reorganisation of actin filaments, as revealed by fluorescein isothiocyanate (FITC)-phalloidin staining and confocal microscopy. We hypothesised that these effects would be associated to lower levels of cytosolic Ca(2+). Indeed, short time loading with calcium green confirmed that verapamil-treated fibroblasts exhibited lower intracellular calcium levels compared to controls. We also observed that verapamil increases the secretion of MMP1 in cultured fibroblasts, as demonstrated by zymography, specific substrate assays and immunoblot. The morphological alterations induced by verapamil are neither cytotoxic nor associated with other dramatic cytoskeleton alterations. Thus we may conclude that this drug enhances collagenase secretion and does not disrupt the major tracks necessary to deliver these enzymes in the extracellular space. The present results suggested that verapamil could be used at physiological levels to enhance collagen I breakdown, and maybe considered a potential candidate for intralesional therapy of wound healing and fibrocontractive diseases. (C) 2010 Elsevier Ltd and ISBI. All rights reserved.

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A neuropsicologia investiga a expressão comportamental das disfunções cerebrais, isto é, a interação entre estruturas cerebrais preservadas e prejudicadas e as funções cognitivas, tais como linguagem, memória, atenção e outras. A neuropsicologia pediátrica possui especificidades: maturação, estratégias cognitivas, ensino formal e cultura, e características intrínsecas à reorganização cerebral. O objetivo da reabilitação neuropsicológica é estabelecer estratégias para adaptação de funções cognitivas afetadas em relação às demandas do ambiente da criança. A reabilitação cognitiva pediátrica auxilia crianças com deficiência mental, epilepsia, traumatismo craniencefálico, síndromes autísticas, tumores cerebrais, paralisia cerebral, etc. Programas de reabilitação neuropsicológica podem ser voltados para dificuldades acadêmicas ou para funções cognitivas. A investigação da efetividade de programas de reabilitação depende de diversos fatores. O neuropsicólogo deve contribuir para o desenvolvimento de novas estratégias de reabilitação cognitiva, ser qualificado para o uso das mesmas e partilhar, com a equipe interdisciplinar, as técnicas e experiências efetivas.

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The Third Caribbean Development Roundtable (23-24 April 2014) was held under the theme “Exploring strategies for sustainable growth and development in Caribbean Small Island Developing States (SIDS)”. The Roundtable focused on challenges faced in stimulating growth and creating a capacity for resilience among the Caribbean SIDS. The conference examined the continuing challenge of igniting robust growth in Caribbean Small States, and at the same time, mitigating structural and cyclical risks and uncertainty. The presentations made at the Roundtable can be placed under six themes which comprise the sections of this report, namely: Macroeconomic reorganisation in the context of risk and uncertainty; fiscal adjustment, stabilisation and debt management; services, public/private partnership and development; social protection; human capital formation; and environmental protection.

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Focalizando o período de 1836 a 1839, essa dissertação aborda as ações de tentativa de reorganização da Província do Pará, nos conturbados anos da Cabanagem, sob o comando do governo do português Francisco José de Sousa Soares d‟Andréa. Enviado pela Regência, Soares d’Andréa usou de medidas firmes para retomar o controle da Província das mãos dos cabanos, que para ele eram homens malvados que espalhavam o terror no Pará. Para ele, e outras lideranças anticabanas, havia uma importante relação entre a natureza, a índole da população e os cabanos, assim como a ausência de civilização estava relacionada com as carências da Província; elementos esses facilmente percebidos nos seus discursos, nas suas correspondências trocadas com seus superiores e outras autoridades. A documentação pesquisada também aponta para discursos destoantes do pensamento de Soares d’Andréa, permitindo, portanto, uma nova visão da imagem construída sobre o Presidente da Província. Portanto analisa-se a construção de uma imagem sobre os cabanos e as forças contrárias ao discurso de Soares d’Andréa. Também discute-se as ideias do Presidente e de lideranças anticabanas relativas a um antagonismo entre a humanidade e a natureza da Província e o entendimento que faziam sobre as necessidades do Pará no seu processo de reconstrução e civilização.

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This study deals with the protection of social rights in Europe and aims to outline the position currently held by these rights in the EU law. The first two chapters provide an overview of the regulatory framework in which the social rights lie, through the reorganisation of international sources. In particular the international instruments of protection of social rights are taken into account, both at the universal level, due to the activity of the United Nations Organisation and of its specialized agency, the International Labour Organization, and at a regional level, related to the activity of the Council of Europe. Finally an analysis of sources concludes with the reconstruction of the stages of the recognition of social rights in the EU. The second chapter describes the path followed by social rights in the EU: it examines the founding Treaties and subsequent amendments, the Charter of Fundamental Social Rights of Workers of 1989 and, in particularly, the Charter of Fundamental Rights of the European Union, the legal status of which was recently treated as the primary law by the Treaty of Lisbon signed in December 2007. The third chapter is, then, focused on the analysis of the substantive aspects of the recognition of the rights made by the EU: it provides a framework of the content and scope of the rights accepted in the Community law by the Charter of Fundamental Rights, which is an important contribution to the location of the social rights among the fundamental and indivisible rights of the person. In the last section of the work, attention is focused on the two profiles of effectiveness and justiciability of social rights, in order to understand the practical implications of the gradual creation of a system of protection of these rights at Community level. Under the first profile, the discussion is focused on the effectiveness in the general context of the mechanisms of implementation of the “second generation” rights, with particular attention to the new instruments and actors of social Europe and the effect of the procedures of soft law. Second part of chapter four, finally, deals with the judicial protection of rights in question. The limits of the jurisprudence of the European Union Court of Justice are more obvious exactly in the field of social rights, due to the gap between social rights and other fundamental rights. While, in fact, the Community Court ensures the maximum level of protection to human rights and fundamental freedoms, social rights are often degraded into mere aspirations of EU institutions and its Member States. That is, the sources in the social field (European Social Charter and Community Charter) represent only the base for interpretation and application of social provisions of secondary legislation, unlike the ECHR, which is considered by the Court part of Community law. Moreover, the Court of Justice is in the middle of the difficult comparison between social values and market rules, of which it considers the need to make a balance: despite hesitancy to recognise the juridical character of social rights, the need of protection of social interests has justified, indeed, certain restrictions to the free movement of goods, freedom to provide services or to Community competition law. The road towards the recognition and the full protection of social rights in the European Union law appears, however, still long and hard, as shown by the recent judgments Laval and Viking, in which the Community court, while enhancing the Nice Charter, has not given priority to fundamental social rights, giving them the role of limits (proportionate and justified) of economic freedoms.

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The application of Concurrency Theory to Systems Biology is in its earliest stage of progress. The metaphor of cells as computing systems by Regev and Shapiro opened the employment of concurrent languages for the modelling of biological systems. Their peculiar characteristics led to the design of many bio-inspired formalisms which achieve higher faithfulness and specificity. In this thesis we present pi@, an extremely simple and conservative extension of the pi-calculus representing a keystone in this respect, thanks to its expressiveness capabilities. The pi@ calculus is obtained by the addition of polyadic synchronisation and priority to the pi-calculus, in order to achieve compartment semantics and atomicity of complex operations respectively. In its direct application to biological modelling, the stochastic variant of the calculus, Spi@, is shown able to model consistently several phenomena such as formation of molecular complexes, hierarchical subdivision of the system into compartments, inter-compartment reactions, dynamic reorganisation of compartment structure consistent with volume variation. The pivotal role of pi@ is evidenced by its capability of encoding in a compositional way several bio-inspired formalisms, so that it represents the optimal core of a framework for the analysis and implementation of bio-inspired languages. In this respect, the encodings of BioAmbients, Brane Calculi and a variant of P Systems in pi@ are formalised. The conciseness of their translation in pi@ allows their indirect comparison by means of their encodings. Furthermore it provides a ready-to-run implementation of minimal effort whose correctness is granted by the correctness of the respective encoding functions. Further important results of general validity are stated on the expressive power of priority. Several impossibility results are described, which clearly state the superior expressiveness of prioritised languages and the problems arising in the attempt of providing their parallel implementation. To this aim, a new setting in distributed computing (the last man standing problem) is singled out and exploited to prove the impossibility of providing a purely parallel implementation of priority by means of point-to-point or broadcast communication.

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Die Kapsidproteine L1 und L2 von humanen Papillomviren (HPV) werden im Cytoplasma infizierter Keratinocyten synthetisiert und gelangen unabhängig voneinander in den Kern (Florin et al. 2002b). L2 lokalisiert in speziellen Kerndomänen, sog. ND10, und induziert die Reorganisation dieser Kernstrukturen: L2-abhängig akkumuliert der transkriptionelle Modulator Daxx verstärkt in ND10 und außerdem kommt es zum Ausschluss des transkriptionellen Aktivators Sp100 aus diesen Domänen (Florin et al. 2002a). Im Anschluss an diese Umorganisation im Kern induziert L2 die Lokalisation des Kapsidproteins L1 in ND10 (Florin et al. 2002b). Da auch die Replikation und Transkription von Papillomviren in oder in unmittelbarer Nähe von ND10 stattfinden, werden ND10 als Orte der Papillomvirus-Morphogenese diskutiert (Swindle et al. 1999). Innerhalb dieser Arbeit konnte gezeigt werden, dass L1 und L2 im Cytoplasma der Zellen mit Chaperonen interagieren, und dass der Kerntransport von L2 von der L2/Hsc70-Assoziation abhängig ist. Hsc70, das mit dem C-Terminus von L2 assoziiert ist, wird in virusähnliche Partikel (VLPs) eingebaut. Erst durch die Verpackung von DNA in die Kapside kommt es zum Ausschluss von Hsc70 aus dem Papillomvirus-Kapsid. Ergebnisse dieser Arbeit lassen zudem vermuten, dass L2 über seinen C-Terminus mit Mikrotubuli interagieren kann, falls diese Aminosäure-Region in L2 nicht durch das Chaperon maskiert wird. Mit Hilfe dieser Erkenntnisse wurde eine Modellvorstellung für die Rolle von L2 während der Infektion und der Morphogenese von HPV entwickelt. Die ND10-Lokalisationsdomäne (NDLD) in L2 konnte wie bei keinem Protein zuvor auf eine sehr kurze Sequenz von 22 Aminosäuren eingeengt werden. Welcher Mechanismus für die ND10-Lokalisation verantwortlich ist, muss dagegen noch geklärt werden. Alle L2-Mutanten, die ND10-Lokalisation zeigen, induzieren auch die Reorganisation dieser Domänen. Dies spricht dafür, dass L2 direkt in ND10 die Veränderungen hervorruft und wahrscheinlich keine zusätzlichen Domänen in L2 daran beteiligt sind. Es konnten zwei L1-Interaktionsdomänen in L2 kartiert werden. Diese beiden Regionen in L2 konnten nicht genauer lokalisiert werden und umfassen möglicherweise mehrere L1-Interaktionsdomänen. Der Einbau von L2 in die Kapside kann nur im Kern infizierter Zellen stattfinden. Hierfür ist die Lokalisation der Kapsidproteine in ND10 nicht notwendig. Weiterführende Versuche müssen jedoch noch klären, inwieweit ND10 trotzdem unerlässlich für eine produktive Morphogenese sind. Zudem wurde klar, dass die ersten 150 Aminosäuren im L2-Protein für das L1/L2-Verhältnis in Kapsiden verantwortlich sind. In Virionen beträgt dieses Verhältnis 30:1, d. h. zwölf L2-Moleküle werden in die Partikel aus 360 L1-Molekülen eingebaut. Bei der Verwendung der Deletionsmutante L2-150/467 beträgt dieses Verhältnis 5:1. Weitere Analysen, welche Regionen von L1 und L2 miteinander interagieren und wodurch die Beschränkung des L1/L2-Verhältnisses in Papillomviren zustande kommt, können genauere Einblicke in den Aufbau der Kapside und speziell die Lage von L2 im Kapsid liefern.