Felipe IV. Rey de España [Material gráfico]

Resumen: Descripción: retrato ecuestre de Felipe IV

El gran tacaño

UANL

La relación médico-paciente revisada desde la perspectiva de la acción dramática: estudio realizado en el Clinicentro Ciudad Salitre E.P.S. Sánitas

Se prueba la hipótesis de trabajo, la cual afirma que el corto tiempo de consulta y la participación entre los actores durante su encuentro afectan la apropiación del modelo participativo de relación médico-paciente por parte de los profesionales

Evaluation of estrogen receptor alpha and beta and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki-67 in breast cancers

To elucidate the molecular profile of hormonal steroid receptor status, we analyzed ER-alpha, ER-beta, and PGR mRNA and protein expression in 80 breast carcinomas using reverse transcriptase polymerase chain reaction (RT-PCR), quantitative RT-PCR, and immunohistochemical analysis. Qualitative analysis revealed positive expression of ER-alpha, ER-beta, and PGR mRNA in 48%, 59%, and 48% of the breast carcinomas, respectively. ER-alpha, ER-beta, and PGR transcript overexpression was observed in 51%, 0%, and 12% of the cases, respectively, whereas moderate or strong protein expression was detected in 68%, 78%, and 49% of the cases, respectively. Tumor grade was negatively correlated with transcript and protein levels of ER-alpha (P = .0169 and P = .0006, respectively) and PGR (P = .0034 and P = .0005, respectively). Similarly, proliferative index Ki-67 was negatively associated with transcript and protein levels of ER-alpha (P = .0006 and P < .0001, respectively) and PGR (P = .0258 and P =. 0005, respectively). These findings suggest that ER-alpha and PGR expression are associated with well-differentiated breast tumors and less directly related to cell proliferation. A significant statistical difference was observed between lymph node status and ER-beta protein expression (P = .0208). In ER-alpha-negative tumors, we detected a correlation between ER-beta protein expression and high levels of Ki-67. These data suggest that ER-beta could be a prognostic marker in human breast cancer. (C) 2008 Elsevier B.V. All rights reserved.

CDHI promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer

Background: the E-cadherin gene (CDH1) maps, at chromosome 16q22.1, a region often associated with loss of heterozygosity (LOH) in human breast cancer. LOH at this site is thought to lead to loss of function of this tumor suppressor gene and was correlated with decreased disease-free survival, poor prognosis, and metastasis. Differential CpG island methylation in the promoter region of the CDH1 gene might be an alternative way for the loss of expression and function of E-cadherin, leading to loss of tissue integrity, an essential step in tumor progression.Methods: the aim of our study was to assess, by Methylation-Specific Polymerase Chain Reaction (MSP), the methylation pattern of the CDH1 gene and its possible correlation with the expression of E-cadherin and other standard immunohistochemical parameters (Her-2, ER, PgR, p53, and K-67) in a series of 79 primary breast cancers ( 71 infiltrating ductal, 5 infiltrating lobular, 1 metaplastic, 1 apocrine, and 1 papillary carcinoma).Results: CDH1 hypermethylation was observed in 72% of the cases including 52/71 ductal, 4/5 lobular carcinomas and 1 apocrine carcinoma. Reduced levels of E-cadherin protein were observed in 85% of our samples. Although not statistically significant, the levels of E-cadherin expression tended to diminish with the CDH1 promoter region methylation. In the group of 71 ductal cancinomas, most of the cases of showing CDH1 hypermethylation also presented reduced levels of expression of ER and PgR proteins, and a possible association was observed between CDH1 methylation and ER expression ( p = 0.0301, Fisher's exact test). However, this finding was not considered significant after Bonferroni correction of p-value.Conclusion: Our preliminary findings suggested that abnormal CDH1 methylation occurs in high frequencies in infiltrating breast cancers associated with a decrease in E-cadherin expression in a subgroup of cases characterized by loss of expression of other important genes to the mammary carcinogenesis process, probably due to the disruption of the mechanism of maintenance of DNA methylation in tumoral cells.

Casos reservados en el Arzobispado de Valencia, como se hallan en el Synodo que celebro ... D. Martin de Ayala y se contienen en el Ritual Valentino, en el tratado del sacramento de la penitencia : daseles la explicacion que trae ... Juan Egidio Trullench ...

El texto esta firmado por el doctor Mayoral, que fué Arzobispo de Valencia entre 1738 y 1769

Lady Cathe Manners (Lady Forester) [Material gráfico]

En la parte inferior consta: "The original Picture burnt at Belvoir Castle"

[Niño con serpiente enroscada en la cabeza] [Material gráfico]

Resumen: Descripción: retrato de niño sentado, sin vestiduras y con una serpiente enroscada en la cabeza que representa a Roscio

Sir Joseph Banks, Bart. [Material gráfico] : Proof.

Resumen: Descripción: retrato de tres cuartos de figura de frente, mirando ligeramente hacia la izquierda. Con la mano derecha nos muestra una pequeña bola

Lupus de Vega Carpio [Material gráfico]

Resumen: Descripción: retrato de Lope de Vega de tres cuartos de figura, ligeramente hacia la derecha, mirando de frente

Caesar Divi Filius III. Vir RP. C. [Material gráfico] : ex marmore antiquo apud ios nic de Azara

Resumen: Descripción: retrato de busto de César basado en una escultura

L. C. Sylla [Material gráfico]

Resumen: Descripción: retrato de busto de Sylla basado en una escultura

C. N. Magn. F. Pompeius [Material gráfico]

Inscripción en el lateral derecho: "Magnit Gemmae"

Lysias [Material gráfico] : ex marmore antiquo apud Ios. Nic. de Azara

Resumen: Descripción: retrato de busto de Lisias basado en una escultura