Intercultural Approaches to Cities and Spaces in Literature, Film, and New Media: a review of new work by Manzanas and Benito and Lopez-Varela and Net

Intercultural Approaches to Cities and Spaces in Literature, Film, and New Media: a review of new work by Manzanas and Benito and Lopez-Varela and Net

N-Methyl-d-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain

Morbidity and mortality from head trauma is highest among children. No animal model mimicking traumatic brain injury in children has yet been established, and the mechanisms of neuronal degeneration after traumatic injury to the developing brain are not understood. In infant rats subjected to percussion head trauma, two types of brain damage could be characterized. The first type or primary damage evolved within 4 hr and occurred by an excitotoxic mechanism. The second type or secondary damage evolved within 6–24 hr and occurred by an apoptotic mechanism. Primary damage remained localized to the parietal cortex at the site of impact. Secondary damage affected distant sites such as the cingulate/retrosplenial cortex, subiculum, frontal cortex, thalamus and striatum. Secondary apoptotic damage was more severe than primary excitotoxic damage. Morphometric analysis demonstrated that the N-methyl-d-aspartate receptor antagonists 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonate and dizocilpine protected against primary excitotoxic damage but increased severity of secondary apoptotic damage. 2-Sulfo-α-phenyl-N-tert-butyl-nitrone, a free radical scavenger, did not affect primary excitotoxic damage but mitigated apoptotic damage. These observations demonstrate that apoptosis and not excitotoxicity determine neuropathologic outcome after traumatic injury to the developing brain. Whereas free radical scavengers may prove useful in therapy of head trauma in children, N-methyl-d-aspartate antagonists should be avoided because of their propensity to increase severity of apoptotic damage.

The teacher in literature as portrayed in the writings of Ascham, Moliere, Rousseau, Shenstone, Fuller, Pestalozzi, Cowper, Goethe, Irving, Mitford, Bronte, Thompson, Thackeray, Hughes, Dickens, Eliot and others. Including a biographical sketch and characterization of each author.

Mode of access: Internet.

A Directory of agencies involved in the study of occupational trauma in Alaska.

Mode of access: Internet.

The use of computers in literature searching and related reference activities in libraries : papers presented at the 1975 Clinic on Library Applications of Data Processing, April 27-30, 1975 /

Includes bibliographical references.

Authors and publishers : a manual of suggestions for beginners in literature, comprising a description of publishing methods and arrangements ... together with general hints for authors /

First published anonymously in 1883.

An explanatory and pronouncing dictionary of the noted names of fiction,: including also familiar pseudonyms, surnames bestowed on eminent men, and analogous popular appellations often referred to in literature and conversation.

Mode of access: Internet.

Recovered yesterdays in literature.

Shakespeare's men.--The literature of nature.--Selfish womanhood.--Tennyson's men.--On reading beautiful books.--A poet Chrysostom.--Recovered yesterdays.--The literature of devotion.--Once again with Elia.

The national fifth reader : containing a complete and practical treatise on elocution, select and classified exercises in reading and declamation, with biographical sketches, and copious notes : adapted to the use of students in literature /

On cover: National school series.