983 resultados para Promotor Oct-4


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We identified a transcript named 11M2 on the basis of its strong male-specific expression pattern in the developing mouse gonad. 11M2 was found to be expressed by gonad primordial germ cells (PGCs) of both sexes and down-regulated in female PGCs as they enter prophase I of the first meiotic division, similar to the expression of Oct4. Mouse EST analysis revealed expression only in early-stage embryos, embryonic stem cells and pre-meiotic germ cells. 11M2 corresponds to a recently reported gene variously known as PGC7, stella or Dppa3. We have identified the human orthologue of Dppa3 and find by human EST analysis that it is expressed in human testicular germ cell tumours but not in normal human somatic tissues. The expression patterns of mouse and human DPPA3, in undifferentiated embryonic cells, embryonic germ cells and adult germ cell tumours, together suggest a role for this gene in maintaining cell pluripotentiality.

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General note: Title and date provided by Bettye Lane.

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Pour toute demande de reproduction de contenu se trouvant dans cette publication, communiquer avec l’Association des diplômés de l’UdeM.

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Pour toute demande de reproduction de contenu se trouvant dans cette publication, communiquer avec l’Association des diplômés de l’UdeM.

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Vorbesitzer: Eljāqīm Carmoly; Abraham Merzbacher

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Vorbesitzer: Abraham Merzbacher

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Vorbesitzer: Abraham Merzbacher

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Vorbesitzer: Eljāqīm Carmoly; Abraham Merzbacher

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Vorbesitzer: Abraham Merzbacher

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Digitalisat des Mikrofilms

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Vorbesitzer: Bernhard Rorbach; Bartholomaeusstift Frankfurt am Main

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Vorbesitzer: Leonhardstift Frankfurt am Main