1000 resultados para Plató, 428 o 7-348 o 7 aC. República
Resumo:
Colbertinus
Resumo:
Référence bibliographique : Toledano, Marieschi, 5f
Resumo:
The cellular actions of genistein, and its in vivo metabolites, are believed to mediate the decreased risk of breast cancer associated with high soy consumption. The genistein metabolite, 5,7,3',4'-tetrahydroxyisoflavone (THIF), induced G2-M cell cycle arrest in T47D tumorigenic breast epithelial cells via a mechanism involving the activation of ataxia telangiectasia and Rad3-related kinase (ATR) via its phosphorylation at Ser(428). This activation of ATR appeared to result from THIF-induced increases in intracellular oxidative stress, a depletion of cellular GSH and an increase in DNA strand breakage. THIF treatment also led to an inhibition of cdc2, which was accompanied by the phosphorylation of both p53 (Ser(15)) and Chk1 (Ser(296)) and the de-activation of cdc25C phosphatase. We suggest the anti-proliferative actions of THIF may be mediated by initial oxidative DNA damage, activation of ATR and downstream regulation of the p53 and Chk1 pathways leading to cell cycle arrest in G2-M. This may represent one mechanism by which genistein exerts its cellular activity in vivo. (c) 2007 Elsevier Inc. All rights reserved.
Resumo:
Publication information: Chicago, Ill. : Everts & Stewart, 1874.
Resumo:
Drawn & compiled by Cyrus Wheelock. Publication information: Chicago, Ill. : Everts & Stewart, 1874.
Resumo:
Drawn & compiled by Frank Krause, C. E.., Ann Arbor. Publication information: Chicago, Ill. : Everts & Stewart, 1874.
Resumo:
Reprinted from Rheinisches museum für philologie. n.f. bd. XXXVII.
Resumo:
"June 1965."
Resumo:
Newsletter for Information Tecnology Department
Resumo:
Des Moines River Plat Maps.
Resumo:
Des Moines River Plat Maps.