Extent of coronary artery disease and outcomes after ticagrelor administration in patients with an acute coronary syndrome: Insights from the PLATelet inhibition and patient Outcomes (PLATO) trial.

BACKGROUND Extensive coronary artery disease (CAD) is associated with higher risk. In this substudy of the PLATO trial, we examined the effects of randomized treatment on outcome events and safety in relation to the extent of CAD. METHODS Patients were classified according to presence of extensive CAD (defined as 3-vessel disease, left main disease, or prior coronary artery bypass graft surgery). The trial's primary and secondary end points were compared using Cox proportional hazards regression. RESULTS Among 15,388 study patients for whom the extent of CAD was known, 4,646 (30%) had extensive CAD. Patients with extensive CAD had more high-risk characteristics and experienced more clinical events during follow-up. They were less likely to undergo percutaneous coronary intervention (58% vs 79%, P < .001) but more likely to undergo coronary artery bypass graft surgery (16% vs 2%, P < .001). Ticagrelor, compared with clopidogrel, reduced the composite of cardiovascular death, myocardial infarction, and stroke in patients with extensive CAD (14.9% vs 17.6%, hazard ratio [HR] 0.85 [0.73-0.98]) similar to its reduction in those without extensive CAD (6.8% vs 8.0%, HR 0.85 [0.74-0.98], Pinteraction = .99). Major bleeding was similar with ticagrelor vs clopidogrel among patients with (25.7% vs 25.5%, HR 1.02 [0.90-1.15]) and without (7.3% vs 6.4%, HR 1.14 [0.98-1.33], Pinteraction = .24) extensive CAD. CONCLUSIONS Patients with extensive CAD have higher rates of recurrent cardiovascular events and bleeding. Ticagrelor reduced ischemic events to a similar extent both in patients with and without extensive CAD, with bleeding rates similar to clopidogrel.

Del neobarroco al plato de ajioaco : Una lectura sobre de donde son los cantares de Severo Saduy

Fil: Sancholuz, Carolina. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Del neobarroco al plato de ajioaco : Una lectura sobre de donde son los cantares de Severo Saduy

Fil: Sancholuz, Carolina. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

As teorias da visão no Ocidente medieval até ao século XII: o comentário de Calcídio ao Timeu de Platão e a obra de Adelardo de Bath

A tradução do Timeu de Platão por Calcídio e respectivo Comentário, no século IV, encetou uma longa tradição no estudo da óptica durante a Idade Média, tradição esta que irá dominar até ao século XIII. O século XII, no entanto, irá ser marcado por um novo olhar neste campo, situação a que não é alheia a influência árabe que, pela mão de tradutores cristãos do ocidente, trouxe novas aportações científicas que vieram a contribuir para o desenvolvimento das correntes filosóficas sobre a matéria. Um desses tradutores foi Adelardo de Bath que, em pleno século XII, quer traduzindo obras árabes até aí desconhecidas do ocidente cristão, quer através da sua produção própria, lavrará o terreno adequado para o advento das sucessivas revoluções que a partir do século XIII surgiram neste campo.

Aristodemocracy : from the great war back to Moses, Christ, and Plato ; an essay /

Mode of access: Internet.