Essays on competition in the pharmaceutical industry

Chapter 1: Patents and Entry Competition in the Pharmaceutical Industry: The Role of Marketing Exclusivity. Effective patent length for innovation drugs is severely curtailed because of extensive efficacy and safety tests required for FDA approval, raising concern over adequacy of incentives for new drug development. The Hatch-Waxman Act extends patent length for new drugs by five years, but also promotes generic entry by simplifying approval procedures and granting 180-day marketing exclusivity to a first generic entrant before the patent expires. In this paper we present a dynamic model to examine the effect of marketing exclusivity. We find that marketing exclusivity may be redundant and its removal may increase generic firms' profits and social welfare. ^ Chapter 2: Why Authorized Generics?: Theoretical and Empirical Investigations Facing generic competition, the brand-name companies some-times launch generic versions themselves called authorized generics. This practice is puzzling. If it is cannibalization, it cannot be profitable. If it is divisionalization, it should be practiced always instead of sometimes. I explain this phenomenon in terms of switching costs in a model in which the incumbent first develops a customer base to ready itself against generic competition later. I show that only sufficiently low switching costs or large market size justifies launch of AGs. I then use prescription drug data to test those results and find support. ^ Chapter 3: The Merger Paradox and R&D Oligopoly theory says that merger is unprofitable, unless a majority of firms in industry merge. Here, we introduce R&D opportunities to resolve this so-called merger paradox. We have three results. First, when there is one R&D firm, that firm can profitably merge with any number of non-R&D firms. Second, with multiple R&D firms and multiple non-R&D firms, all R&D firms can profitably merge. Third, with two R&D firms and two non-R&D firms, each R&D firms prefer to merge with a non-R&D firm. With three or more than non-R&D firms, however, the R&D firms prefer to merge with each other.^

Characterization Of Single Use Reactor Used For The Manufacturing Of Formulated Products Within The Pharmaceutical Industry

Mixing is a fundamental unit operation in the pharmaceutical industry to ensure consistent product quality across different batches. It is usually carried out in mechanically stirred tanks, with a large variety of designs according to the process requirements. A key aspect of pharmaceutical manufacturing is the extensive and meticulous cleaning of the vessels between runs to prevent the risk of contamination. Single-use reactors represent an increasing trend in the industry since they do not require cleaning and sterilization, reducing the need for utilities such as steam to sterilize equipment and the time between production batches. In contrast to traditional stainless steel vessels, single-use reactors consist of a plastic bag used as a vessel and disposed of after use. This thesis aims to characterize the fluid dynamics features and the mixing performance of a commercially available single-use reactor. The characterization employs a combination of various experimental techniques. The analysis starts with the visual observation of the liquid behavior inside the vessel, focusing on the vortex shape evolution at different impeller speeds. The power consumption is then measured using a torque meter to quantify the power number. Particle Image Velocimetry (PIV) is employed to investigate local fluid dynamics properties such as mean flow field and mean and rms velocity profiles. The same experimental setup of PIV is exploited for another optical measurement technique, the Planar Laser-Induced Fluorescence (PLIF). The PLIF measurements complete the characterization of the reactor with the qualitative visualization of the turbulent flow and the quantitative assessment of the system performance through the mixing time. The results confirm good mixing performances for the single-use reactor over the investigated impeller speeds and reveal that the filling volume plays a significant role in the fluid dynamics of the system.

Quality, Productivity and Economy in Welding Manufacturing - Case Study: West Africa

This thesis studies quality, productivity and economy in welding manufacturing in West African states such as Ghana, Nigeria and Cameroon. The study consists of two parts: the first part, which forms the theoretical background, reviews relevant literature concerning the metal and welding industries, and measurement of welding quality, productivity and economy. The second part, which is the empirical part, aims to identify activities in the metal manufacturing industries where welding is extensively used and to determine the extent of welding quality, productivity and economy measurements in companies operating in the metal manufacturing industries. Additionally, the thesis aims to identify challenges that companies face and to assess the feasibility of creating a network to address these issues. The research methods used in the empirical part are the case study (qualitative) method and the survey (quantitative) method. However, the case study method was used to elicit information from companies in Ghana, while the survey method was used to elicit information from companies in Nigeria and Cameroon. The study considers important areas that contribute to creating awareness and understanding of the current situation of the welding industry in West Africa. These areas include the metal manufacturing industrial sector, metal products manufactured, metal production and manufacturing systems deployed, welding quality, productivity and economy measurement systems utilized, equipment and materials on the markets, general challenges facing companies in welding operations, welding technology programs and research in local universities, and SWOT analysis of the various West African states. The notable findings indicate that majority of the companies operate in the constructionindustrial sector. Also, majority of the companies are project manufacturing oriented, thus provide services to customers operating in the growing industries such as the oil and gas, mining, food and the energy industry. In addition, only few companies are certified under standards such as ISO 9001, ISO 3834, and OHSAS 18001. More so, majority of the companies employ manual welding technique, and shielded metal arc welding (SMAW) as the commonly used welding process. Finally, welder salary is about € 300 / month as of June 2013 and the average operations turnover of medium to large companies is about € 5 million / year as at 2012. Based on analysis of the results of the study, it is noted that while welding activities are growing, the availability of cheap labor, the need for company and welder qualification and certification, and the need to manufacture innovative products through developmental projects (transfer of welding expertise and technology) remain as untapped opportunities in the welding industry in the West African states. The study serves as a solid platform for further research and concludes with several recommendations for development of the West African welding industry.

Three new birds from West Africa [by] Austin L. Rand and Melvin A. Traylor.

v.39:no.25(1959)

Utilisation of biomass for energy production in the North-West Russian forest industry

Traditionally, fossil fuels have always been the major sources of the modern energy production. However prices on these energy sources have been constantly increasing. The utilization of local biomass resources for energy production can substitute significant part of the required energy demand in different energy sectors. The introduction of the biomass usage can easily be started in the forest industry first as it possesses biomass in a large volume. The forest industry energy sector has the highest potential for the fast bioenergy development in the North-West Russia. Therefore, the question concerning rational and effective forest resources use is important today as well as the utilization of the forestry by-products. This work describes and analyzes the opportunities of utilising biomass, mainly, in the form of the wood by-products, for energy production processes in general, as well as for the northwest Russian forest industry conditions. The study also covers basic forest industry processes and technologies, so, the reader can get familiar with the information about the specific character of the biomass utilization. The work gives a comprehensive view on the northwest forest industry situation from the biomass utilisation point of view. By presenting existing large-scale sawmills and pulp and paper mills the work provides information for the evaluation of the future development of CHP investments in the northwest Russian forest industry.

West & North Africa, ca. 1710 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte de la Barbarie, le [sic] la Nigritie et del la Guinée, par Guillaume de l'Isle de l'Academie Royale des Sciences. It was published by ex officina Nicolai Visscher, ca. 1710. Scale [ca.1:9,000,000]. Covers West and North Africa. Map in French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Africa Sinusoidal projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, routes and roads, territorial boundaries, shoreline features, and more. Relief shown pictorially. Includes notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

West & North Africa, ca. 1730 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte de la Barbarie, le la Nigritie et de la Guinée, par Guill[au]me Del'Isle, de l'Academie Royale des Sciences. It was published by Chez Jean Cóvens et Corneille Mortier, Geographes ca. 1730. Scale [ca.1:9,250,000]. Covers West and North Africa. Map in French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Africa Sinusoidal projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads and routes, territorial boundaries, shoreline features, and more. Relief shown pictorially. Includes notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

North & West Africa, 1655 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: L'Afrique, ou Lybie ulterieure : ou sont le Saara, ou desert, le pays des Negres, la Guinee, et les pays circonv. tirée en partie de Sanut, et de l'Arabe de Nubie, en partie de diverses cartes veües jusques a present par le S. Sanson d'Abbeville, geog. ordre. du Roy ; I. Somer Pruthenus, sculp. It was published by Chez Pierre Mariette, rue St. Iacques a l'Esperance in 1655. Scale [ca. 1:10,500,000]. Covers portions of North and West Africa. Map in French.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Miller Cylindrical projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief shown pictorially.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

West & Central Africa, ca. 1690 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Effigies ampli Regni auriferi Guineae in Africa siti, extensum inde ad insulis Atlanticis, vulgo dictis, de Cabo Verde : ad flumen Benin, us[que], ad cujus ripam sita est Regia urbs et magna Benin, at[que] inde ad promontorium Lopi Gonsalvi, delineata per S. Rovelascum, et politioribus lineamentis figurata per Lodovicum Texeram, protocosmographum Regis Hispaniarum ; Baptista Doetechomius sculpsit ; Carolus Allardt excudit. It was published by Carolus Allardt ca. 1690. Scale [ca. 1:8,000,000]. Covers portions of West and Central Africa. Map in Latin and Portuguese.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Miller Cylindrical projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, shoreline features, and more. Includes also illustrations and text.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

West & Central Africa, ca. 1752 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Guinea propria : nec non Nigritiae vel terrae Nigrorum maxima pars : Geographis hodiernis dicta utraque Aethiopia Inferior, & huius quidem pars australis ex delineationibus Anvillianis itineri Guineensi D. de Marchais insertis secundum Leges proiectionis stereographicae Hasianae, designata & edita studio & labore Homannianorum Heredum A. 1743 = Guinée de meme que la plus grande parties du pais des Negres : appellées par les geographes modernes Ethiopie inferieure et meridionale, tirées des morceaux geographiques de Mr. d'Anville, qu'il a inseres au voyage du Chev. de Marchais, & puis dessinées suivant les loix de la nouvelle projection de feu Mr. le prof. Has, par les Heritiers d'Homan. A 1743. It was published by edita studio & labore Homannianorum Heredum ca. 1752. Scale [ca. 1:7,400,000]. Covers portions of West and Central Africa. Map in Latin.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Miller Cylindrical projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief shown pictorially. Includes also notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

West & Central Africa, ca. 1753 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A new and correct map of the coast of Africa : from Cape Blanco lat. 20°40'. N. to the coast of Angola lat. 11°. S. : with explanatory notes of all the forts and settlements belonging to the several European powers, R. W. Seale, sculp. It was published by J. & P. Knapton ca. 1753. Scale [ca. 1:10,000,000]. Covers portions of West and Central Africa.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Miller Cylindrical projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial claims, forts, factories, shoreline features, and more. Includes also notes, index, and inset: A separate map of the Gold Coast, upon a larger scale.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

West & Central Africa, 1809 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Charte von Senegambien und Ober-Guinea : nebst dem innern Nigritien : nach den neuesten Nachrichten entworfen. It was published by im Verl. des Geograph. Instituts in 1809. Scale [ca. 1:9,250,000]. Covers portions of West and Central Africa. Map in German.The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Miller Cylindrical projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, roads, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief shown pictorially. Includes also notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

West & Central Africa, 1873 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Stanford's map of the Guinea Coast, West Africa including the whole course of the Niger, and shewing Ashanti and its surroundings. It was published by E. Stanford in 1873. Scale 1:6,336,000. Covers portions of West and Central Africa.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Africa Sinusoidal projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries and claims, roads, exploration routes, shoreline features, and more. Relief shown by hachures and spot heights. Includes notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

West & North Africa, 1810 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Charte von Nord-Africa : nach dem neuesten Entdeckungen. It was published in 1810. Scale [ca. 1:9,875,000]. Covers West & North Africa and a portion of Europe. Map in German.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Europe Lambert Conformal Conic coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads and routes, territorial boundaries, shoreline features, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

West Africa, 1799 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Charte des Reisewegs des Herrn Mungo Park : von Pisania am Gambia Fluss, bis Silla am Joliba oder Nieger, nebst seine Rückreise auf der südlichen Strasse nach Pisania, nach Her. Parks Beobachtungen, Bemerkungen u. Reisen entworfen von J. Rennell It was published by B.G. Hoffmann in 1799. Scale [ca. 1:5,000,000]. Covers a portion of West Africa. Map in German.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Africa Lambert Conformal Conic projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, roads, shoreline features, and more. Relief shown pictorially. Includes notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.