Paul I. Landmann manufacturing factory; Mannheim-Neckarau Business Establishments; Factories

"Fabrikansicht von der Toreinfahrt"

Factory employee housing; Paul I. Landmann Manufacturing Factory; Mannheim-Neckarau Business Establishments; Factories

"Arbeiter und Mietshaeuser"

Factory employee housing; Paul I. Landmann Manufacturing Factory; Mannheim-Neckarau Business Establishments; Factories

"Arbeiter und Mietshaeuser"

50th wedding anniversary party of Paul Goldschmidt and Ilse nee Molling; Laguna Hills, CA.

Left to right: Margot Molling, Ilse Molling, Adolf Molling, Paul Goldschmidt (husband of Ilse Molling)

50th wedding anniversary party of Paul Goldschmidt and Ilse nee Molling; Laguna Hills, California.

left to right: Margot Molling, Ilse Molling, Adolf Molling, Paul Goldschmidt (husband of Ilse Molling)

Portrait of Dr. Paul Ornstein Portraits Men

Dr. Paul Ornstein in the early 1940s at his desk at the Barker Central School in Barker, NY, where he served as school physician.

Paul Eppstein; Reichsvertretung der Juden in Deutschland Portraits; Men

Digital Image

Paul; Montevideo, Uruguay Portraits Men

Paul was the son from a previous marriage of Hermann Judey's first wife Olga Judey nee Fischmann

Group portrait, testimonial dinner for Dr. Paul Klemperer's 10th anniversary at Mt. Sinai Hospital given by his students; Cavanagh's, New York City Portraits Groups

Digital Image

The story of Paul Hinrichsen - Auschwitz Victim 1989

Manuscript by Henry E. Stanton: "The Story of Paul Hinrichsen - Auschwitz Victim". Life of the author's uncle, his childhood, education and agricultural studies, his Jewish identification and the impact of anti-Semitism and Nazi persecution on his life.

Paul Seligman Collection

Offprint from "The Jewish Quarterly Review" on Leo Baeck's "The People Israel." Newspaper clippings referring to his appointment as professor emeritus. Manuscript on Leo Baeck. Article on the German artist Friedrich Adler.

Julius Paul Eppstein Collection 1932-1939

Letters from Max Warburg (May 1938) and Otto Hirsch (March 1939), thanking him for his contributions to Reichsvertretung and Hilfsverein. Also included are pages from a Jewish calendar for Wuerttemberg 1932/33.

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

Although the importance of clathrin- and caveolin-independent endocytic pathways has recently emerged, key aspects of these routes remain unknown. Using quantitative ultrastructural approaches, we show that clathrin-independent carriers (CLICs) account for approximately three times the volume internalized by the clathrin-mediated endocytic pathway, forming the major pathway involved in uptake of fluid and bulk membrane in fibroblasts. Electron tomographic analysis of the 3D morphology of the earliest carriers shows that they are multidomain organelles that form a complex sorting station as they mature. Proteomic analysis provides direct links between CLICs, cellular adhesion turnover, and migration. Consistent with this, CLIC-mediated endocytosis of key cargo proteins, CD44 and Thy-1, is polarized at the leading edge of migrating fibroblasts, while transient ablation of CLICs impairs their ability to migrate. These studies provide the first quantitative ultrastructural analysis and molecular characterization of the major endocytic pathway in fibroblasts, a pathway that provides rapid membrane turnover at the leading edge of migrating cells.