Colección completa de los tratados, convenciones, capitulaciones, armisticios y otros actos diplomáticos de todos los estados de la América Latina comprendidos entre el golfo de Méjico y el cabo de Hornos desde el año 1493 hasta nuestros días... /

Tomo primero -- Tomo segundo.

Operator's, organizational, and direct support maintenance manual : radar set AN/APN-215(V)1 (NSN-5841-01-093-1493) and radar set AN/APN-215(V)3 (NSN 5841-01-134-3346).

"23 November 1983."

A calendar of wills proved in the Consistory Court of the Bishop of Gloucester, 1541 [to 1800]

Wills during 1653-60 were proved in London, hence must be sought in the Principal Registry, Somerset House. cf. v. 1, p. viii.

DIE BUCHDRUCKERTATIGKEIT GEORG ERLINGERS IM BAMBERG VON 1522 BIS 1541

Mode of access: Internet.

Abstracts from the wills and testamentary documents of binders, printers, and stationers of Oxford, from 1493 to 1638.

Mode of access: Internet.

Die Mittenberger Bibelrevisionskommissionen von 1531 bis 1541 und ihr Ertrag fur die deutsche Luhterbibel.

Thesis (doctoral)--Universitat Breslau.

Vida y obra de Don Juan Suárez de Peralta : cronista y protoalbéytar de América : el hombre de las dos España (1541-1613)

Don Juan Suárez de Peralta nació en la ciudad de México-Tenochtitlán en 1541, habiendo sido sus padres Don Juan Suárez Marcayda y Doña Magdalena de Peralta; el padre también conocido como Juan Suárez de Ávila, o como Juan Suárez “El Viejo”, hizo la campaña militar de la conquista del Imperio Azteca como compañero de armas de Don Hernán Cortés. Suárez de Peralta escribió tres grandes obras: “Tractado de Alveiteria” hacia 1575, “Tractado de Cavallería de la Gineta y Brida” en 1580 y “Tractado del Descubrimiento de las Indias y su Conquista” en 1589. Estos tres tratados hacen de Suárez de Peralta, una inevitable y riquísima fuente de información para todo historiador investigando las vetas de la Historia Virreinal Novohispana y de la Historia de España del siglo XVI. Su obra sobre medicina equina y zootecnia de los caballos, es un magnífico y estupendo trabajo que se levanta como el primer libro de su tipo escrito en América. Suárez de Peralta asociado con su hermano mayor, Don Luis, establece un criadero de caballos de raza fina en Tacubaya, en el poniente de la antigua ciudad de México, y es ahí en donde aprende el arte científico de la médica equina, de la reproducción y de la zootecnia caballar y sus habilidades como jinete y gran caballista. En 1579, Don Juan debido a una serie de circunstancias decide exiliarse a España arribando al puerto de Sanlúcar de Barrameda, como huésped en el Palacio de su pariente el VII Conde-Duque de Medina Sidonia, para después habitar en Trujillo y en Sevilla en donde escribe y publica sus otras dos grandes obras. Se muda a Madrid en donde contrae nupcias con una aristócrata dama de la alta nobleza castellana, Doña Isabel Hurtado de Mendoza, perteneciente a la poderosa Casa del Infantado. Con ella procrea un hijo, llamado Don Lorenzo Suárez de Peralta, quien viaja a la Nueva España para tomar posesión de los bienes de su padre, su abuelo y de su tío Luís. Don Juan, nuestro albéitar, quien “alladese enfermo de calenturas”, fallece el 8 de enero de 1613 y es enterrado en la Iglesia del Spiritu Sanctus de los Clérigos Menores en el Madrid de los Austrias. Su manuscrito “Libro de Alveitería”, permaneció olvidado y sin publicar durante más de tres cientos años en la Biblioteca Nacional de Madrid, hasta que finalmente ve la luz en la ciudad de México, en ocasión del Centenario de la fundación de la Escuela Nacional de Medicina Veterinaria y Zootecnia y del IV Centenario de la Real y Pontificia Universidad de México, ahora, Universidad Nacional Autónoma de México (UNAM) en 195

Agosto de 1541: ¡por fin nos descubrieron!

Fondo Margaritainés Restrepo

Raman spectroscopic characteristics of phthalocyanine and naphthalocyanine in sandwich-type phthalocyaninato and porphyrinato rare earth complexes Part 5. – Raman spectroscopic characteristics of naphthalocyanine in mixed [tetrakis(4-tert-butylphenyl)porphyrinato]-(naphthalocyaninato) rare earth double-deckers

Raman spectra were recorded in the range 400–1800 cm−1 for a series of 15 mixed \[tetrakis(4-tert-butylphenyl)porphyrinato](2,3-naphthalocyaninato) rare earth double-deckers M(TBPP)(Nc) (M = Y; La–Lu except Pm) using laser excitation at 632.8 and 785 nm. Comparisons with bis(naphthalocyaninato) rare earth counterparts reveal that the vibrations of the metallonaphthalocyanine M(Nc) fragment dominate the Raman features of M(TBPP)(Nc). When excited with radiation of 632.8 nm, the most intense vibration appears at about 1595 cm−1, due to the naphthalene stretching. These complexes exhibit the marker Raman band for Nc•− as a medium-intense band in the range 1496–1507 cm−1, attributed to the coupling of pyrrole and aza stretching, while the marker Raman band of Nc2− in intermediate-valence Ce(TBPP)(Nc) appears as a strong band at 1493 cm−1 and is due to the isoindole stretchings. By contrast, when excited with radiation of 785 nm that is in close resonance with the main Q absorption band of the naphthalocyanine ligand, the ring radial vibrations at ca 680 and 735 cm−1 for MIII(TBPP)(Nc) are selectively intensified and are the most intense bands. For the cerium double-decker, the most intense vibration also acting as the marker Raman band of Nc2− appears at 1497 cm−1 with contributions from both pyrrole CC and aza CN stretches. The same vibrational modes show weak to medium intensity scattering at 1506–1509 cm−1 for MIII(TBPP)(Nc) and this is the marker Raman band of Nc•− when thus excited. The scatterings due to the Nc breathings, ring radial vibration, aza group stretchings, naphthalene stretchings, benzoisoindole stretchings and the coupling of pyrrole CC and aza CN stretchings in MIII(TBPP)(Nc) are all slightly blue shifted along with the decrease in rare earth ionic radius, confirming the effects of increased ring–ring interactions on the Raman characteristics of naphthalocyanine in the mixed ring double-deckers.

Estimation of parameters for macroparasite population evolution using approximate Bayesian computation

We estimate the parameters of a stochastic process model for a macroparasite population within a host using approximate Bayesian computation (ABC). The immunity of the host is an unobserved model variable and only mature macroparasites at sacrifice of the host are counted. With very limited data, process rates are inferred reasonably precisely. Modeling involves a three variable Markov process for which the observed data likelihood is computationally intractable. ABC methods are particularly useful when the likelihood is analytically or computationally intractable. The ABC algorithm we present is based on sequential Monte Carlo, is adaptive in nature, and overcomes some drawbacks of previous approaches to ABC. The algorithm is validated on a test example involving simulated data from an autologistic model before being used to infer parameters of the Markov process model for experimental data. The fitted model explains the observed extra-binomial variation in terms of a zero-one immunity variable, which has a short-lived presence in the host.

Multivariate Markov Process Models for the transmission of methicillin-resistant Staphylococcus Aureus in a hospital ward

Methicillin-resistant Staphylococcus Aureus (MRSA) is a pathogen that continues to be of major concern in hospitals. We develop models and computational schemes based on observed weekly incidence data to estimate MRSA transmission parameters. We extend the deterministic model of McBryde, Pettitt, and McElwain (2007, Journal of Theoretical Biology 245, 470–481) involving an underlying population of MRSA colonized patients and health-care workers that describes, among other processes, transmission between uncolonized patients and colonized health-care workers and vice versa. We develop new bivariate and trivariate Markov models to include incidence so that estimated transmission rates can be based directly on new colonizations rather than indirectly on prevalence. Imperfect sensitivity of pathogen detection is modeled using a hidden Markov process. The advantages of our approach include (i) a discrete valued assumption for the number of colonized health-care workers, (ii) two transmission parameters can be incorporated into the likelihood, (iii) the likelihood depends on the number of new cases to improve precision of inference, (iv) individual patient records are not required, and (v) the possibility of imperfect detection of colonization is incorporated. We compare our approach with that used by McBryde et al. (2007) based on an approximation that eliminates the health-care workers from the model, uses Markov chain Monte Carlo and individual patient data. We apply these models to MRSA colonization data collected in a small intensive care unit at the Princess Alexandra Hospital, Brisbane, Australia.

Functional role of cell surface CUB domain-containing protein 1 in tumour cell dissemination

The function of CUB domain-containing protein 1 (CDCP1), a recently described transmembrane protein expressed on the surface of hematopoietic stem cells and normal and malignant cells of different tissue origin, is not well defined. The contribution of CDCP1 to tumor metastasis was analyzed by using HeLa carcinoma cells overexpressing CDCP1 (HeLa-CDCP1) and a high-disseminating variant of prostate carcinoma PC-3 naturally expressing high levels of CDCP1 (PC3-hi/diss). CDCP1 expression rendered HeLa cells more aggressive in experimental metastasis in immunodeficient mice. Metastatic colonization by HeLa-CDCP1 was effectively inhibited with subtractive immunization-generated, CDCP1-specific monoclonal antibody (mAb) 41-2, suggesting that CDCP1 facilitates relatively late stages of the metastatic cascade. In the chick embryo model, time- and dose-dependent inhibition of HeLa-CDCP1 colonization by mAb 41-2 was analyzed quantitatively to determine when and where CDCP1 functions during metastasis. Quantitative PCR and immunohistochemical analyses indicated that CDCP1 facilitated tumor cell survival soon after vascular arrest. Live cell imaging showed that the function-blocking mechanism of mAb 41-2 involved enhancement of tumor cell apoptosis, confirmed by attenuation of mAb 41-2–mediated effects with the caspase inhibitor z-VAD-fmk. Under proapoptotic conditions in vitro, CDCP1 expression conferred HeLa-CDCP1 cells with resistance to doxorubicin-induced apoptosis, whereas ligation of CDCP1 with mAb 41-2 caused additional enhancement of the apoptotic response. The functional role of naturally expressed CDCP1 was shown by mAb 41-2–mediated inhibition of both experimental and spontaneous metastasis of PC3-hi/diss. These findings confirm that CDCP1 functions as an antiapoptotic molecule and indicate that during metastasis CDCP1 facilitates tumor cell survival likely during or soon after extravasation.