Memorie raccolte da suo figlio.

Mode of access: Internet.

Caterina Sforza /

Supplemented by the author's Caterina Sforza, nuovi documenti. (Bologna, 1897)

Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth

One classical feature of cancer cells is their metabolic acquisition of a highly glycolytic phenotype. Carbon monoxide (CO), one of the products of the cytoprotective molecule heme oxygenase-1 (HO-1) in cancer cells, has been implicated in carcinogenesis and therapeutic resistance. However, the functional contributions of CO and HO-1 to these processes are poorly defined. In human prostate cancers, we found that HO-1 was nuclear localized in malignant cells, with low enzymatic activity in moderately differentiated tumors correlating with relatively worse clinical outcomes. Exposure to CO sensitized prostate cancer cells but not normal cells to chemotherapy, with growth arrest and apoptosis induced in vivo in part throughmitotic catastrophe. CO targeted mitochondria activity in cancer cells as evidenced by higher oxygen consumption, free radical generation, and mitochondrial collapse. Collectively, our findings indicated that CO transiently induces an anti-Warburg effect by rapidly fueling cancer cell bioenergetics, ultimately resulting in metabolic exhaustion. ©2013 AACR.

Della malignita ?istorica, discorsi tre di A*** B*** [i.e. Appiano Buonafede.] contro Pier France?sco Le Courayer ; nuovo interprete della istoria del concilio di Trento di Pietro Soave ...

Mode of access: Internet.

Riposta di Anton Giuseppe Branchi di Castel Fiorentino, scolare nello Studio pisano [pseud.] a quanto oppone il signor Giovan Paolo Lucardesi al libro dell' eccellentissimo signor dottore Anton Francesco Bertini intitolato Lo specchio che non adula ...

Manuscript note on fly-leaf: Del senat. Da Verrazzano ora pero di Giuseppe Lemi priore di Ricorboli. 1850.

Bianca and Julius Rosenbaum kissing on a pier Portraits Couples

Digital Image

Bianca and Julius Rosenbaum kissing on a pier Portraits Couples

Digital Image

En los inicios del Renacimiento. La cúpula brunelleschiana y reflexiones sobre Paolo Uccello

Tomando como eje el año 1436 en que es inaugurada solemnemente, a falta de su linterna, la cúpula de la catedral de Florencia y, siendo además este año el de la realización del Acuto de Paolo Uccello, se trata de glosar y reflexionar, unos quinientos ochenta años después, tanto sobre la paradigmática construcción de Brunelleschi, como sobre Uccello y su importante contribución a la historia del arte.