D-3 2007-2 Dependent Adult Abuse Report, July - December 2007

D-3 Dependent Adult Abuse Report

D-3 2008-2 Dependent Adult Abuse Report, July - December 2008

D-3 Dependent Adult Abuse Report

Histoire de la guerre d'Italie. Série 2 / par M. l'abbé Mullois,...

Collection : Bibliothèque de tout le monde

D-3 2008-2 Dependent Adult Abuse Report, January - June 2009

D-3 Dependent Adult Abuse Report

Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that induces cancer cell death by apoptosis with some selectivity. TRAIL-induced apoptosis is mediated by the transmembrane receptors death receptor 4 (DR4) (also known as TRAIL-R1) and DR5 (TRAIL-R2). TRAIL can also bind decoy receptor 1 (DcR1) (TRAIL-R3) and DcR2 (TRAIL-R4) that fail to induce apoptosis since they lack and have a truncated cytoplasmic death domain, respectively. In addition, DcR1 and DcR2 inhibit DR4- and DR5-mediated, TRAIL-induced apoptosis and we demonstrate here that this occurs through distinct mechanisms. While DcR1 prevents the assembly of the death-inducing signaling complex (DISC) by titrating TRAIL within lipid rafts, DcR2 is corecruited with DR5 within the DISC, where it inhibits initiator caspase activation. In addition, DcR2 prevents DR4 recruitment within the DR5 DISC. The specificity of DcR1- and DcR2-mediated TRAIL inhibition reveals an additional level of complexity for the regulation of TRAIL signaling.

Bjahennibi (1) ; Bjahennibi (2) / Dalila Taliana, chant [acc. voc. et instr.]

[Traditions. Afrique du Nord. Tunisie]

Progama de salud para tutorias de 1º y 2º de la E.S.O. en el colegio Nuestra Señora del Carmen de zaragoza

Este proyecto es un programa para trabajar diferentes temas de salud para alunmos/as de 1º y 2º de la E.S.O. en las tutorias del centro.

Definición del diseño de las estaciones y paradas de las líneas 1 y 2 del metro de Málaga

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