Estudo do extrato de Ginkgo biloba na prevenção de malformações em recémnascidos de ratas diabéticas

The pregnant women presenting Diabetes mellitus develop metabolic alterations, that may cause damage to the fetal well-being and provoke anomalies and/or malformations. The antioxidant treatment has improved the embryonic development from streptozotocin diabetic rats. Several studies have shown that a Gingko biloba extract presents antioxidant effects and, in the present study, one of the G. biloba extract formulations was used (EGb761) - Tebonin (200 mg/Kg/day), given to the diabetic pregnant female rats. The aim was to evaluate the effect of the EGb761 treatment on the of anomalies and/ or malformations incidence of the offspring. Diabetes was induced in female rats using streptozotocin in a dose of 40 mg/kg. The rats were mated, and the pregnant animals were divided in two groups: Control (water) and experimental (G. biloba). At day 21 of pregnancy, the rats were killed, and their fetuses were analyzed and processed for anomalies and/or malformations incidence. The results demonstrated that control and experimental groups presented no external anomalies and malformations; increased incidence of skeletal anomalies and of visceral malformations, and lower rate of visceral anomalies and skeletal malformations. These data confirm no statistical difference and, therefore, EGb761 treatment did not cause changes. Thus, a dose of 200 mg/Kg/day of a Gingko biloba extract given during the pregnancy rat was ineffective in the prevention of the anomalies and/or malformations related to the diabetes.

Compreendendo o significado da gestação para grávidas diabéticas.

This qualitative study intends to understand the meaning of pregnancy for diabetic women. Semi-structured interviews were carried out and data were analyzed by means of the Collective Subject Discourse, identifying the following central ideas: happiness about a desired pregnancy, preoccupation with pregnancy and renouncement, my pregnancy was planned, I had other plans, I feel what pregnant women feel, I had many problems during pregnancy, a child was everything that he wanted, he didn't feel the same emotions as a woman, I am controlling, doing everything the doctor says, I am trying to follow a diet, but it is hard. These central ideas demonstrate that, among the diabetic pregnant women, planning and wanting the pregnancy and counting on the support of the family and/or companion were also essential for the treatment to be faced naturally and for the pregnancy to be experienced in a pleasant way.

Efeito do extrato aquoso de folhas de Polymnia sonchifolia (yacon) em ratas diabéticas

Polymnia sonchifolia is a medicinal plant used as hypoglycemic agent and other ends. The aim was to evaluate the yacon effect on diabetes in Wistar female rats, which was divided in 4 groups: non-diabetic (n=24) given (gavage) 32.4 mg kg -1 of an aqueous extract of plant (treated group) or vehicle (non-treated group), and one diabetic group (n=24) with similar treatment compared to non-diabetic rats. Diabetes was induced using streptozotocin (i.v. route, 40 mg kg -1). Glycemia was monitored after rodent adaptation period, 15 days after diabetes induction, and each 10 days after yacon/vehicle in early treatment. During experiment period, body weights, food and water intake were daily measured. The rats (non-diabetic or diabetic) given yacon extract treatment presented no significant difference related with glycemia, body weight gain, and food and water intake. Thus, further studies such increase of rat number in agreement with different glycemic levels and increase of the plant extract dose are necessary.

Avaliação de custos das internações de gestantes diabéticas de um Hospital Universitário do interior de São Paulo

This study aimed at identifying the hospitalization costs of pregnant women with Diabetes Mellitus (DM) at a University Hospital. It is an observational, quantitative study with descriptive data analysis. The direct and indirect costs available in the institution were identified in order to determine the hospitalization costs for patients diagnosed with DM during pregnancy and childbirth. By means of descriptive statistics, it was observed that 63.46% of the patients had caesarean delivery; the mean total cost was R$ 362.93 (U$ 218.10)/hospitalization during pregnancy, R$ 2,642.65 (U$ 1,588.13)/hospitalization for caesarean delivery, and R$ 2.319.77 (U$ 1,394.09)/hospitalization for vaginal delivery. It was concluded that the analysis of hospitalization costs for patients with DM is of utmost importance, since they are highcomplexity hospitalizations that require a large number of interventions, increasing thus the service costs.

Programa de exercícios físicos: análise dos fatores de risco cardiovaculares e biomarcadores de inflamação e estresse oxidativo em diabéticas exercitadas e não exercitadas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação metabólica de ratas prenhez diabéticas tratadas com flavonóide quercetina e repercurssões na prole

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Repercussões maternas, reprodutivas e perinatais do tratamento com extrato aquoso de folhas de Bauhinia forficata (Pata-de-vaca) na prenhez de ratas não-diabéticas e diabéticas

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Insulina e dexametasona na aerocistite aguda induzida por Aeromonas hydrophila em tilápias do Nilo, Oreochromis niloticus, Aloxano-diabéticas

Pós-graduação em Medicina Veterinária - FCAV

Estudo do processo de reparação òssea após implantação do polietileno poroso em defeitos cirúrgicos no osso parietal de ratas diabéticas tratadas com calcitonina

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Intervenção com Azadirachta indica (Neem) na prenhez de ratas diabéticas: repercussões materno-fetais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Alterações morfológicas das fibras I e II do músculo estriado uretral de ratas prenhes diabéticas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Qualidade de vida, ansiedade e depressão em gestantes diabéticas ou co hiperglicemia leve

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Atividade funcional de fagócitos do leite de mães hiperglicêmicas leve e diabéticas e sua regulação neuroimunoendocrinológica: interações com lgA e melatonina

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise morfológica das células beta-pancreáticas de ratas diabéticas em diferentes idades de vida

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Tratamento ambulatorial e hospitalar na monitorização glicêmica de gestantes diabéticas em uso de insulina

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB