999 resultados para Minimal hypotheses semantics
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The kinematics of the anatomical shoulder are analysed and modelled as a parallel mechanism similar to a Stewart platform. A new method is proposed to describe the shoulder kinematics with minimal coordinates and solve the indeterminacy. The minimal coordinates are defined from bony landmarks and the scapulothoracic kinematic constraints. Independent from one another, they uniquely characterise the shoulder motion. A humanoid mechanism is then proposed with identical kinematic properties. It is then shown how minimal coordinates can be obtained for this mechanism and how the coordinates simplify both the motion-planning task and trajectory-tracking control. Lastly, the coordinates are also shown to have an application in the field of biomechanics where they can be used to model the scapulohumeral rhythm.
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Contemporary logic is confined to a few paradigmatic attitudes such as belief, knowledge, desire and intention. My purpose is to present a general model-theoretical semantics of propositional attitudes of any cognitive or volitive mode. In my view, one can recursively define the set of all psychological modes of attitudes. As Descartes anticipated, the two primitive modes are those of belief and desire. Complex modes are obtained by adding to primitive modes special cognitive and volitive ways or special propositional content or preparatory conditions. According to standard logic of attitudes (Hintikka), human agents are either perfectly rational or totally irrational. I will proceed to a finer analysis of propositional attitudes that accounts for our imperfect but minimal rationality. For that purpose I will use a non standard predicative logic according to which propositions with the same truth conditions can have different cognitive values and I will explicate subjective in addition to objective possibilities. Next I will enumerate valid laws of my general logic of propositional attitudes. At the end I will state principles according to which minimally rational agents dynamically revise attitudes of any mode.
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In standard multivariate statistical analysis common hypotheses of interest concern changes in mean vectors and subvectors. In compositional data analysis it is now well established that compositional change is most readily described in terms of the simplicial operation of perturbation and that subcompositions replace the marginal concept of subvectors. To motivate the statistical developments of this paper we present two challenging compositional problems from food production processes. Against this background the relevance of perturbations and subcompositions can be clearly seen. Moreover we can identify a number of hypotheses of interest involving the specification of particular perturbations or differences between perturbations and also hypotheses of subcompositional stability. We identify the two problems as being the counterpart of the analysis of paired comparison or split plot experiments and of separate sample comparative experiments in the jargon of standard multivariate analysis. We then develop appropriate estimation and testing procedures for a complete lattice of relevant compositional hypotheses
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Synthetic vaccines constitute the most promising tools for controlling and preventing infectious diseases. When synthetic immunogens are designed from the pathogen native sequences, these are normally poorly immunogenic and do not induce protection, as demonstrated in our research. After attempting many synthetic strategies for improving the immunogenicity properties of these sequences, the approach consisting of identifying high binding motifs present in those, and then performing specific changes on amino-acids belonging to such motifs, has proven to be a workable strategy. In addition, other strategies consisting of chemically introducing non-natural constraints to the backbone topology of the molecule and modifying the a-carbon asymmetry are becoming valuable tools to be considered in this pursuit. Non-natural structural constraints to the peptide backbone can be achieved by introducing peptide bond isosters such as reduced amides, partially retro or retro-inverso modifications or even including urea motifs. The second can be obtained by strategically replacing L-amino-acids with their enantiomeric forms for obtaining both structurally site-directed designed immunogens as potential vaccine candidates and their Ig structural molecular images, both having immunotherapeutic effects for preventing and controlling malaria.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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We investigate a neutrino mass model in which the neutrino data is accounted for by bilinear R-parity violating supersymmetry with anomaly mediated supersymmetry breaking. We focus on the CERN Large Hadron Collider (LHC) phenomenology, studying the reach of generic supersymmetry search channels with leptons, missing energy and jets. A special feature of this model is the existence of long-lived neutralinos and charginos which decay inside the detector leading to detached vertices. We demonstrate that the largest reach is obtained in the displaced vertices channel and that practically all of the reasonable parameter space will be covered with an integrated luminosity of 10 fb(-1). We also compare the displaced vertex reaches of the LHC and Tevatron.
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Red blood cells (RBCs) from most vertebrates restore volume upon hypertonic shrinkage and the mechanisms underlying this regulatory volume increase (RVI) have been studied extensively in these cells. Despite the phylogenetically interesting position of reptiles, very little is known about their red cell function. The present study demonstrates that oxygenated RBCs in all major groups of reptiles exhibit no or a very reduced RVI upon -25% calculated hyperosmotic shrinkage. Thus, RBCs from the snakes Crotalus durissus and Python regius, the turtle Trachemys scripta and the alligator Alligator mississippiensis showed no statistically significant RVI within 120 min after shrinkage, while the lizard Tupinambis merianae showed 22% volume recovery after 120 min. Amiloride (10(-4) M) and bumetanide (10(-5) M) had no effect on the RVI in T merianae, indicating no involvement of the Na(+)/H(+) exchanger (NHE) or the Na(+)/K(+)/2Cl(-) co-transporter (NKCC) or insentive transporters. Deoxygenation of RBCs from A. mississippiensis and T merianae did not significantly affect RVI upon shrinkage. Deoxygenation per se of red blood cells from T merianae elicited a slow volume increase, but the mechanism was not characterized. It seems, therefore, that the RVI response based on NHE activation was lost among the early sauropsids that gave rise to modern reptiles and birds, while it was retained in mammals. An RVI response has then reappeared in birds, but based on activation of the NKCC. Alternatively, the absence of the RVI response may represent the most ancient condition, and could have evolved several times within vertebrates. (C) 2008 Elsevier B.V. All rights reserved.
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The recent experimental results on neutrino oscillation and on muonium-antimuonium conversion require extension of the minimal 3-3-1 model. We review the constraints imposed on the model by these measurements and suggest a pattern of leptonic mixing, with charged leptons in a non-diagonal basis, which accounts for the neutrino physics and circumvents the tight muonium-antimuonium bounds on the model. We also illustrate a scenario where this pattern could be realized.
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In the minimal 3-3-1 model charged leptons come in a nondiagonal basis. Moreover, the Yukawa interactions of the model lead to a non-hermitian charged lepton mass matrix. In other words, the minimal 3-3-1 model presents a very complex lepton mixing. In view of this we check rigorously if the possible textures of the lepton mass matrices allowed by the minimal 3-3-1 model can lead or not to the neutrino mixing required by the recent experiments in neutrino oscillation.
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The measurability of the non-minimal coupling is discussed by considering the correction to the Newtonian static potential in the semiclassical approach. The coefficient of the gravitational Darwin term (GDT) gets redefined by the non-minimal torsion scalar couplings. Based on a similar analysis of the GDT in the effective field theory approach to non-minimal scalar, we conclude that for reasonable values of the couplings the correction is very small.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)