Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia

Anti-factor VIII (FVIII) inhibitory IgG may arise as alloantibodies to therapeutic FVIII in patients with congenital hemophilia A, or as autoantibodies to endogenous FVIII in individuals with acquired hemophilia. We have described FVIII-hydrolyzing IgG both in hemophilia A patients with anti-FVIII IgG and in acquired hemophilia patients. Here, we compared the properties of proteolytic auto- and allo-antibodies. Rates of FVIII hydrolysis differed significantly between the two groups of antibodies. Proline-phenylalanine-arginine-methylcoumarinamide was a surrogate substrate for FVIII-hydrolyzing autoantibodies. Our data suggest that populations of proteolytic anti-FVIII IgG in acquired hemophilia patients are different from that of inhibitor-positive hemophilia A patients.

Structural Studies of Analgesics and Their Interactions. VIII.* Rotational Isomerism and Disorder in the Crystal Structure of Meelofenamie Acid

Meclofenamic acid, C I4HIICI2NO2, probably the most potent among analgesic fenamates, crystallizes in the triclinic space group P1, with a = 8.569 (5), b = 8.954(8), c -- 9.371 (4) A, ct = 103.0 (2), fl -- 103.5 (2), y = 92.4 (2) ° , Z = 2, D m = 1.43 (4), D c = 1.41 Mg m -3. The structure was solved by direct methods and refined to R = 0.135 for 1062 observed reflections. The anthranilic acid moiety in the molecule is nearly planar and is nearly perpendicular to the 2,6-dichloro-3-methylphenyl group. The molecules, which exist as hydrogen-bonded dimers, have an internal hydrogen bond involving the imino and the carboxyl groups. The methyl group is disordered and occupies two positions with unequal occupancies. The disorder can be satisfactorily explained in terms of the rotational isomerism of the 2,6-dichloro-3-methylphenyl group about the bond which connects it to the anthranilic acid moiety and the observed occupancies on the basis of packing considerations.

Varied Immune Response to FVIII: Presence of Proteolytic Antibodies Directed to Factor VIII in Different Human Pathologies

The versatility of antibodies is demonstrated by the various functions that they mediate such as neutralization, agglutination, fixation of the complement and its activation, and activation of effector cells. In addition to this plethora of functions, antibodies are capable of expressing enzymatic activity. Antibodies with catalytic function are a result of the productive interplay between the highly evolved machinery of the immune system and the chemical framework used to induce them (antigens). Catalytic antibodies are immunoglobulins with an ability to catalyze the reactions involving the antigen for which they are specific. Catalytic immunoglobulins of the IgM and IgG isotypes have been detected in the serum of healthy donors. In addition, catalytic immunoglobulins of the IgA isotype have been detected in the milk of healthy mothers. Conversely, antigen-specific hydrolytic antibodies have been reported in a number of inflammatory, autoimmune, and neoplastic disorders. The pathophysiological occurrence and relevance of catalytic antibodies remains a debated issue. Through the description of the hydrolysis of coagulation factor VIII as model target antigen, we propose that catalytic antibodies directed to the coagulation factor VIII may play a beneficial or a deleterious role depending on the immuno-inflammatory condition under which they occur.

Sterochemical studies on cyclic peptides-VIII. Conformational analysis of hydrogen bonded cyclohexaglycyl molecule with a centre of inversion symmetry

A study on the conformational aspects of cyclo-hexaglycyl having inversion symmetry has been made. The cyclic backbone has been assumed to have two internal 4→1 types of NH... O hydrogen bonds. This molecule has been found to take up two types of conformations designated asA* andB* having nearly the same energy values. The theoretical conformations have been compared with the conformations of cyclohexaglycyl hemihydrate observed in the crystal structure. Two molecules with an approximate inversion symmetry are close to the conformation of the typeB* and two other molecules with exact inversino symmetry correspond nearly to the typesB* andA*. comparison with the theoretically possible conformations of cyclohexaglycyl molecule with 2-fold symmetry has been made. The preference of inversion symmetry and preferred ranges ofψ for glycyl molecules is discussed.

Steroids and related natural products. VIII. Synthesis of oxasteroids

Peroxydisulfuric acid oxidation of testosterone propionate, progesterone, and cholest-4-en-3-one has been shown to yield 3-oxo-17β-hydroxy-4-oxa-5α-androstane (I, after saponification), 3,20-dioxo-4-oxa-5α-pregnane (V) and 3-oxo-4-oxa-5α-cholestane (VII) respectively. Boron trifluoride etherate-lithium aluminum hydride reduction of δ-lactones I, V, and VII led to the corresponding tetrahydropyran derivatives (IIb, VIa, and VIII). Similar reduction of 3β-hydroxy-17-oxo-17a-oxa-D-homo-5α-androstane (XI) gave 3β-hydroxy-17a-oxa-D-homo-5α-androstane (XIIa). Diborane-boron trifluoride etherate was also found to reduce lactones to cyclic ethers, while reduction with diborane gave hemiacetals. Evidence in support of the structures and stereochemistry assigned to the lactones and their unusual reduction products has been summarized. A tentative mechanism is proposed for lactone → ether reduction employing diborane-boron trifluoride etherate.

Organometallic chemistry of diphosphazanes *1: VIII. Synthesis, spectroscopic studies and crystal structure of fac-[Mo(CO)3(MeCN)Ph2PN(iPr)P(Ph)(DMP)], and its reactions with tertiary phosphines

The reaction of fac-[Mo(CO)3(MeCN)3] with the unsymmetrical diphosphazane Ph2PN(iPr)P(Ph)(DMP) (L) gives the complex fac-[Mo(CO)3(MeCN)(L)] (2) in almost quantitative yield. The structure of the complex has been determined by an X-ray diffraction study. The compound reacts with PR3 (where R = Ph, OPh) to give fac-[Mo(CO)3(PR3)(L)] (3a, 4a), which undergoes an intramolecular isomerization to afford mer-[Mo(CO)3(PR3)(L)] (3b, 4b). Synthesis of cis-[Mo(CO)4(L)] (1) and fac-[MO(CO)3L] (2a) and their spectroscopic data are also reported.

Sapientia, 1953, Vol. VIII, nº 28 (número completo)

Contenido: Intolerancia de la verdad y tolerancia del amor / La Dirección – Definición de la metafísica : sus dificultades y su posibilidad / Reginaldo Garrigou-Lagrange O. P. – La oposición estética forma-contenido / Manuel B. Trías – Ética de la subjetividad : en torno a la ética de G. Marcel y K. Jarspers /José Ignacio Alcorta -- Notas y comentarios -- Bibliografía

Sapientia, 1953, Vol. VIII, nº 30 (número completo)

Contenido: Filosofía y vida / La Dirección – Ensayo sobre la acción / J. H. Nicolás O. P. – Reflexión acerca del principio de identidad / José María de Estrada – La evolución del patriotismo en occidente / Raymundo Paniker – Notas y comentarios -- Bibliografía

La violencia de la palabra : la construcción discursiva de los rebeldes musulmanes en Al- Andalus (ss. VIII-X)

Resumen: El propósito del trabajo que presentamos a continuación es abordar la violencia como un aspecto de la construcción discursiva del rebelde musulmán y de la rebelión en al-Andalus entre los siglos VIII y X. En las elaboraciones históricas de los confl ictos sociales que marcaron la construcción del Estado omeya, los episodios violentos infl igidos a rebeldes políticos son un lugar común, pero la violencia como práctica también se encuentra presente explícita o implícitamente en el lenguaje utilizado en dichos discursos. De esta manera, nuestro análisis se centrará en aquellas palabras que contengan evaluaciones positivas o negativas de la fi gura del rebelde y de la rebelión en una de las crónicas históricas más tempranas de al-Andalus, el Ta’rīj iftitāh Al-Andalus de Ibn al-Qūtiyya.

Ensayos de Política Económica, Año VIII, Vol. II, Nº 2, 2014

Contenido: Editorial -- Interaction between a strategic mass media firm and a government / Julián Alberto Batista -- Políticas proteccionistas de la Argentina desde 2003 : del auge a la decadencia económica / Julio J. Nogués -- Lidiando con las estadísticas internacionales en las ciencias sociales / José María Dagnino Pastore ; Luis María Libonatti -- La relación virtuosa de la seguridad y la inversión extranjera directa en Colombia (1994-2013) / Catalina Gómez Toro -- Estimación de la probabilidad de default : un modelo probit para los bancos argentinos / Felipe Klein -- Aproximación a las causas de la desigualdad económica / Maximiliano Mozetic -- Reseñas

Memoria poética y geografía en Don Juan Manuel

Integran este número de la revista ponencias presentadas en Studia Hispanica Medievalia VIII: Actas de las IX Jornadas Internacionales de Literatura Española Medieval, 2008, y de Homenaje al Quinto Centenario de Amadis de Gaula.

Anuario Argentino de Derecho Canónico, 2001, Vol. VIII (número completo)

Contenido: Presentación – Aspectos canónicos de la sexualidad humana 25-27 octubre 1999: La sexualidad humana en el plan de Dios / L. A. Alessio – Varón y mujer : ¿igualdad de derechos? / A. W. Bunge – Importancia canónica de la primera cópula conyugal / C. I. Heredia – La escuela católica. Aspectos jurídicos-canónicos 2-3 octubre 2000: ¿Qué es la escuela católica? / A. W. Bunge – La relación de la escuela católica con los alumnos y sus padres / M. A. Fueyo – El representante legal de la escuela católica / S. Montini – Artículos: Propuestas desde la psicología para unificar criterios en la aplicación del can. 1095 / C. Baccioli – El revés de la trama de los matrimonios nulos / J. Bonet Alcón – El cuidado pastoral de una parroquia sin sacerdote : algunas cuestiones canónicas del can. 517 § 2 / A. D. Busso – Las Conferencias Trienales y el Concilio Plenario de los Obispos de la República Argentina de 1953 / N. C. Dellaferrera – El “obsequium religiosum, intellectus et voluntatis” del can. 752 (II. Parte doctrinal) / P. D. Martínez – Notas – Reseña de documentos pontificios – Legislación particular – Crónica de la Facultad -- Recensiones