999 resultados para Marryat, Frederick, 1792-1848.


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Four letters regarding trade and Tudor’s travels throughout Europe.

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Three letters providing updates on various commercial activities and describing the impact of renewed hostilities between England and France on trade. Included with one letter is a price circular.

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Three letters regarding various bills to be paid.

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Mode of access: Internet.

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Die Kriege von 1792 bis 1815 in Europa und Aegypten is by F.G. Kausler and J.E. Woerl.

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"Quellen" : v. 1., p. 29-47. "Hilfs-wissenschaften und literatur des ungarischen staatsrechts": v. 1, p. 47-82.

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"Letter from Wendell Phillips, Esq.": pages [xiii]-xvi.

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Breast cancer incidence and mortality rates are increasing despite our current knowledge on the disease. Ninety-five percent of breast cancer cases correspond to sporadic forms of the disease and are believed to involve an interaction between environmental and genetic determinants. The microRNA 17–92 cluster host gene (MIR17HG) has been shown to regulate expression of genes involved in breast cancer development and progression. Study of single-nucleotide polymorphisms (SNPs) located in this cluster gene could help provide a further understanding of its role in breast cancer. Therefore, this study investigated six SNPs in the MIR17HG using two independent Australian Caucasian case–control populations (GRC-BC and GU-CCQ BB populations) to determine association to breast cancer susceptibility. Genotyping was undertaken using chip-based matrix assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry (MS). We found significant association between rs4824505 and breast cancer at the allelic level in both study cohorts (GRC-BC p = 0.01 and GU-CCQ BB p = 0.03). Furthermore, haplotypic analysis of results from our combined population determined a significant association between rs4824505/rs7336610 and breast cancer susceptibility (p = 5 × 10−4). Our study is the first to show that the A allele of rs4824505 and the AC haplotype of rs4824505/rs7336610 are associated with risk of breast cancer development. However, definitive validation of this finding requires larger cohorts or populations in different ethnical backgrounds. Finally, functional studies of these SNPs could provide a deeper understanding of the role that MIR17HG plays in the pathophysiology of breast cancer.

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Digital Image

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The sitter was Dr.Ernst Hamburgers (of the L.B.I.Executive Commitee) great grandfather, a master dyer in Berlin by profession. He is shown almost frontally, smiling, dressed up in a suit and fancy shirt.

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Family tree, explanation