Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization

The region of human chromosome 22q11 is prone to rearrangements. The resulting chromosomal abnormalities are involved in Velo-cardio-facial and DiGeorge syndromes (VCFS and DGS) (deletions), “cat eye” syndrome (duplications), and certain types of tumors (translocations). As a prelude to the development of mouse models for VCFS/DGS by generating targeted deletions in the mouse genome, we examined the organization of genes from human chromosome 22q11 in the mouse. Using genetic linkage analysis and detailed physical mapping, we show that genes from a relatively small region of human 22q11 are distributed on three mouse chromosomes (MMU6, MMU10, and MMU16). Furthermore, although the region corresponding to about 2.5 megabases of the VCFS/DGS critical region is located on mouse chromosome 16, the relative organization of the region is quite different from that in humans. Our results show that the instability of the 22q11 region is not restricted to humans but may have been present throughout evolution. The results also underscore the importance of detailed comparative mapping of genes in mice and humans as a prerequisite for the development of mouse models of human diseases involving chromosomal rearrangements.

Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation.

The retinoid X receptor (RXR) participates in a wide array of hormonal signaling pathways, either as a homodimer or as a heterodimer, with other members of the steroid and thyroid hormone receptor superfamily. In this report the ligand-dependent transactivation function of RXR has been characterized, and the ability of RXR to interact with components of the basal transcription machinery has been examined. In vivo and in vitro experiments indicate the RXR ligand-binding domain makes a direct, specific, and ligand-dependent contact with a highly conserved region of the TATA-binding protein. The ability of mutations that reduce ligand-dependent transcription by RXR to disrupt the RXR-TATA-binding protein interaction in vivo and in vitro suggests that RXR makes direct contact with the basal transcription machinery to achieve activation.

Gulf of Mexico and Caribbean Sea Region, ca. 1715 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A map of the West-Indies or the islands of America in the North Sea : with ye adjacent countries, explaning [sic] what belongs to Spain, England, France, Holland &c. also ye trade winds, and ye several tracts made by ye galeons and flota from place to place : according to ye newest and most exact observations, by Herman Moll, geographer. It was printed for Tho. Bowles in St. Pauls Church Yard and John Bowles at the Black Horse in Cornhill ca. 1715. Scale [ca. 1:4,300,000]. Covers the Gulf of Mexico and Caribbean Sea Region including parts of southern United States, Mexico, Central America, West Indies, and northern South America.The image inside the map neatline is georeferenced to the surface of the earth and fit to the North American Lambert Conformal Conic coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief shown pictorially. Includes also historical notes and insets.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Coasts, Mediterranean Sea and Black Sea Region, 1814 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte réduite de la mer Méditerranée et de la mer Noire : dédiée et présentée a S.A.R. M. le duc d'Angoulême..., par P. Lapie, géographe, Directeur du Cabinet topographique du Roi ; gravé par P.A.F. Tardieu. It was published by Rey et Gravier, libraires Quai des Augustins, no. 55 in 1814. Scale [ca. 1:35,500]. Covers Mediterranean Sea, Black Sea, and coasts of Europe, North Africa, and the Middle East. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the World Miller Cylindrical projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, shoreline features, and more. Relief shown pictorially. Depths shown by soundings. Includes also inset map of the Sea of Azov.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Wilmington and Topsail Sound Region, North Carolina, 1865 (Raster Image)

This layer is a georeferenced raster image of the historic, paper manuscript map entitled: Map of country between the N.E. Cape-Fear River and Topsail sound, made under the direction of Capt. Wm. H. James, Chf. Engineer, by B.L. Blackford, Top. Engrs. It was drawn in 1865. Scale 1:40,000. The image inside the map neatline is georeferenced to the surface of the earth and fit to the North Carolina State Plane NAD 1983 coordinate system (in Meters) (Fipszone 3200). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, bridges, drainage, troop camps, lines of defense, selected buildings with names of landowners, mills and salt works, ground cover, swamps, and more. Relief shown by hachures. Includes also ill. of Confederate soldier with a plane table and Confederate flag, at left within margin. This layer is part of a selection of digitally scanned and georeferenced historic maps of the Civil War from the Harvard Map Collection. Many items from this selection are from a collection of maps deposited by the Military Order of the Loyal Legion of the United States Commandery of the State of Massachusetts (MOLLUS) in the Harvard Map Collection in 1938. These maps typically portray both natural and manmade features, in particular showing places of military importance. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Old Northwest and Great Lakes Region, 1785 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A map of the north west parts of the United States of America, [by] John Fitch. It was published in 1785. Scale [ca. 1:3,000,000]. Covers the Old Northwest from the Great Lakes to Kentucky and the Mississippi River to the Allegany River and a portion of Lake Ontario. The image inside the map neatline is georeferenced to the surface of the earth and fit to the USA Contiguous Albers Equal Area Conic projection (Meters). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as human settlements, forts, Native American lands, roads, drainage, proposed state boundaries, and more. Relief shown by landform drawing. Includes descriptive notes. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Isla Grevy and Isla Bayly Region, Islas Wollaston, Tierra del Fuego, Chile, 1891 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Seagull Harbour, Gretton Bay, Wollaston Island : Tierra del Fuego by the U.S. Ex.Ex. 1839 ; R.H. Wyman, Commo. U.S.N. Hydrographer to the Bureau of Navigation. Extensive corr. July 1891. It was published by the Hydrographic Office in 1891. Scale [ca. 1:10,600]. Covers the Isla Grevy and Isla Bayly Region, Islas Wollaston, Tierra del Fuego, Chile. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'Mercator' projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, shoreline features, bays, harbors, inlets, points, rocks, anchorage points and bottom types, and more. Relief shown by hachures. Depths shown by soundings. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Bering Sea and Arctic Ocean Region, 1882 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Behring's Sea and Arctic Ocean : from surveys of the U.S. North Pacific Surveying Expedition in 1855, Commander John Rodgers U.S.N. commanding and from Russian and English authorities, J.C.P. de Kraft, commodore U.S.N. Hydrographer to the Bureau of Navigation ; compiled by E.R. Knorr ; drawn by Louis Waldecker. Corr. & additions to Jan. 1882. It was published by U.S. Navy, Hydrographic Office in 1882. Scale [ca. 1:4,400,000]. Covers the Bering Sea and Arctic Ocean region. The image inside the map neatline is georeferenced to the surface of the earth and fit to a non-standard 'Mercator' projection with the central meridian at 180 degrees west. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. Note: The central meridian of this map is not the same as the Prime Meridian and may wrap the International Date Line or overlap itself when displayed in GIS software. This map shows features such as drainage, cities and other human settlements, territorial boundaries, expedition routes, shoreline features, bays, harbors, islands, rocks, and more. Relief shown by hachures and spot heights. Depths shown by soundings. Includes drawing of Wrangel Island "as seen from Bark Nile of New London ... ; 15 to 18 miles distant". This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection and the Harvard University Library as part of the Open Collections Program at Harvard University project: Organizing Our World: Sponsored Exploration and Scientific Discovery in the Modern Age. Maps selected for the project correspond to various expeditions and represent a range of regions, originators, ground condition dates, scales, and purposes.

Middle East, Tigris and Euphrates River Region, 1779 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: L'Euphrate et le Tigre, par le Sr. d'Anville ; Guill. De La Haye. It was published in 1779. Scale [ca. 1:2,400,000]. Cover the Euphrates and Tigris River region including portions of Iraq, Iran, Kuwait, Turkey, Syria, Jordan, and Lebanon. Map in French and Latin. The image inside the map neatline is georeferenced to the surface of the earth and fit to the a modified 'Europe Lambert Conformal Conic' projection with a central meridian of 44 degrees East projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief shown pictorially. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection as part of the Open Collections Program at Harvard University project: Islamic Heritage Project. Maps selected for the project represent a range of regions, originators, ground condition dates, scales, and purposes. The Islamic Heritage Project consists of over 100,000 digitized pages from Harvard's collections of Islamic manuscripts and published materials. Supported by Prince Alwaleed Bin Talal and developed in association with the Prince Alwaleed Bin Talal Islamic Studies Program at Harvard University.

Cape of Good Hope and Cape Town Region, South Africa, Nautical Chart, 1822 (Raster Image)

This layer is a georeferenced raster image of the historic, paper map entitled: Survey of the Cape of Good Hope, by Lieut. A.T.E. Vidal of H.M.S. Leven, assisted by Captn. Chas. Lechmere, R.N. Lieut T. Boteler, and Mr. H.A. Gibbons, Admlty. Midn. under the direction of Captn. W.F.W. Owen, 1822. J. & C. Walker sculpt. It was published according to Act of Parliament at the Hydrographical Office of the Admiralty, 4th March 1828. Scale [ca. 1:153,512]. Covers the Cape Peninsula region, including False Bay and Cape Town, South Africa. The image inside the map neatline is georeferenced to the surface of the earth and fit to the 'WGS 1984 UTM 34S' coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows coastal features such as beacons, rocks, channels, points, coves, islands, bottom soil types, anchorage points, and more. Includes also selected land features such as roads, drainage, land cover, selected buildings, towns, and more. Relief shown by contours; depths by soundings. Includes notes, table of heights, and two views. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Average hourly earnings in selected industries and occupations by region, 1945-1946.

Mode of access: Internet.

NATO : a time for renewed commitment : report of the Delegation to Northern NATO and the Nordic Region of the Committee on Armed Services, House of Representatives, Ninety-eighth Congress, second session.

Mode of access: Internet.

My spirit's flight and The valley of my dream,/

Poems.

Inventory of non-federally funded marine pollution research, development, and monitoring activities : South Atlantic and Gulf Coastal Region /

Mode of access: Internet.