Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia

Allogeneic bone marrow transplantation has been shown to be a very effective therapy for Chronic Granulocytic Leukemia with long term disease free survivals in excess of 60%. Relapse rates remain low at 15% following histocompatible sibling transplants and lower rates following matched unrelated donor grafts. Relapse rates however, are higher if BMT is carried out in transformation or blast crisis. Leukemic relapse in donor cells following transplantation for CGL is a rare event. The occurrence of donor leukemia however, may be under reported as accurate and sensitive investigation of the origin of relapsed leukemia following BMT requires DNA based technologies. A possible mechanism of donor leukemia in CGL is transfection of donor cells with the chimeric gene which is unique to this disease. It is possible that the malignant cells found in transformed or blast crisis of CGL may have a greater potential to transfect donor haematopoietic material. Careful evaluation of the incidence of donor leukemia using molecular biology methods may elucidate the frequency of this event following BMT for CGL.

World Cultures in English(es) at the School of Arts and Humanities Library, University of Lisbon: the Communication Platform Architecture and Its Critical Analysis

We will consider the architecture of the communication platform prototype, "World Cultures in English(es)" (WCE), in relation to the interaction among different types of media and audiences. Such an architecture has emphasized the need for an interdisciplinary team of scholars, librarians, and Information Technology experts who have conceived the prototype. This prototype was developed using PHP and MySQL, and is based on the University of Lisbon server. The "World Cultures in English(es)" is an Open Access platform bringing together different types of documents—written, audio, visual, multimedia, and electronic—and aims at educational, cultural, social, and economic inclusiveness, namely in terms of users with special needs. The WCE platform strongly implies social commitment through reliable information and forms of communication adequate to different kinds of audiences. The "World Cultures in English(es)" prototype will be tested by different audiences from different schools and universities, leading to the necessary adjustments.

Electrical Development Company of Ontario certificate of stock ownership, ca. 1910.

The Electrical Development Company of Ontario was created in 1903. It was one of three private power companies that had water power leases with the Niagara Parks Commission, but was the only one that was financed with Canadian capital. The company built the Toronto Power Generating Station at Niagara Falls beginning in 1906, and the power house was completed in 1913. During the construction, there was much debate about whether the utility should remain privately operated or become a public utility. In 1920, the company became part of the public utility.

Fourth Annual Report of The Electric Development Company of Ontario Limited For the Year Ending 31st December, 1906

Fourth Annual Report of The Electrical Development Company of Ontario Limited for for the year 1906. The report discusses the main line between Niagara Falls and Toronto and the line between the Township of Pelham and the city of Brantford. The report also details the purchase of stocks and bonds in several different companies.

Indenture between Alfred Sanderson Woodruff and the United States Trust Company of New York

Indenture between Alfred Sanderson Woodruff and the United States Trust Company of New York. The proceeds would be paid to his estate for his successors. January 12, 1894.

Indenture between Hamilton Killaly Woodruff and the United States Trust Company of New York

Indenture between Hamilton Killaly Woodruff and the United States Trust Company of New York. The proceeds would be paid to his successors. (This is a handwritten copy)

Indenture between Hamilton Killaly Woodruff and the United States Trust Company of New York (3rd Trust Deed)

Indenture between Hamilton Killaly Woodruff and the United States Trust Company of New York. This is listed as the 3rd trust deed. The proceeds would be paid to successors (2 copies). Most of the first page of copy no. 2 is torn away which does affect the text. These 2 documents are in an envelope marked "vouchers", June 20, 1899.

Certificate to Announce Thomas Henderson Captain of a Company of the Northern Regiment

Certificate (vellum) to announce that Thomas Henderson is to be Captain of a company of the Northern Regiment of Local Militia in the County of Northumberland, England. The document is stained, faded and contains holes. The text is slightly affected. The signature on this document has been cut away, Sept. 4, 1813.

Telegram from Great North Western Telegraph Company of Canada to S.D. Woodruff from L. Cabot

Telegram from Great North Western Telegraph Company of Canada to S.D. Woodruff from L. Cabot stating that he will take the shares, Jan. 16, 1886.

Telegram from Great North Western Telegraph Company of Canada to S.D. Woodruff from L. Cabot stating that the draft for $5000.00 will be forwarded

Telegram from Great North Western Telegraph Company of Canada to S.D. Woodruff from L. Cabot stating that the draft for $5000.00 will be forwarded on Monday or Tuesday, Jan. 16, 1886.

Letter to W.D. Woodruff from Henry E. Ahern of United States Trust Company of New York

Letter to W.D. Woodruff from Henry E. Ahern of United States Trust Company of New York (1 page, printed) which was sent with a cheque for $2,106 in trust for his account. This is accompanied by an envelope addressed to the trust company, a balance sheet and a receipt, July 14, 1908.