Division of Labor among the α6β4 Integrin, β1 Integrins, and an E3 Laminin Receptor to Signal Morphogenesis and β-Casein Expression in Mammary Epithelial Cells

Contact of cultured mammary epithelial cells with the basement membrane protein laminin induces multiple responses, including cell shape changes, growth arrest, and, in the presence of prolactin, transcription of the milk protein β-casein. We sought to identify the specific laminin receptor(s) mediating the multiple cell responses to laminin. Using assays with clonal mammary epithelial cells, we reveal distinct functions for the α6β4 integrin, β1 integrins, and an E3 laminin receptor. Signals from laminin for β-casein expression were inhibited in the presence of function-blocking antibodies against both the α6 and β1 integrin subunits and by the laminin E3 fragment. The α6-blocking antibody perturbed signals mediated by the α6β4 integrin, and the β1-blocking antibody perturbed signals mediated by another integrin, the α subunit(s) of which remains to be determined. Neither α6- nor β1-blocking antibodies perturbed the cell shape changes resulting from cell exposure to laminin. However, the E3 laminin fragment and heparin both inhibited cell shape changes induced by laminin, thereby implicating an E3 laminin receptor in this function. These results elucidate the multiplicity of cell-extracellular matrix interactions required to integrate cell structure and signaling and ultimately permit normal cell function.

Expression of a Hox gene, Cnox-2, and the division of labor in a colonial hydroid

We report the isolation and expression of the Hox gene, Cnox-2, in Hydractinia symbiolongicarpus, a hydrozoan displaying division of labor. We found different patterns of aboral-to-oral Cnox-2 expression among polyp polymorphs, and we show that experimental conversion of one polyp type to another is accompanied by concordant alteration in Cnox-2 expression. Our results are consistent with the suggestion that polyp polymorphism, characteristic of hydractiniid hydroids, arose via evolutionary modification of proportioning of head to body column.

Common endocrine and genetic mechanisms of behavioral development in male and worker honey bees and the evolution of division of labor.

Temporal polyethism is a highly derived form of behavioral development displayed by social insects. Hormonal and genetic mechanisms regulating temporal polyethism in worker honey bees have been identified, but the evolution of these mechanisms is not well understood. We performed three experiments with male honey bees (drones) to investigate how mechanisms regulating temporal polyethism may have evolved because, relative to workers, drones display an intriguing combination of similarities and differences in behavioral development. We report that behavioral development in drones is regulated by mechanisms common to workers. In experiment 1, drones treated with the juvenile hormone (JH) analog methoprene started flying at significantly younger ages than did control drones, as is the case for workers. In experiment 2, there was an age-related increase in JH associated with the onset of drone flight, as in workers. In experiment 3, drones derived from workers with fast rates of behavioral development themselves started flying at younger ages than drones derived from workers with slower rates of behavioral development. These results suggest that endocrine and genetic mechanisms associated with temporal polyethism did not evolve strictly within the context of worker social behavior.

Research series - Department of Labor and Industry, Division of Employment Security.

No more published?

Report on the improvement of the City of Dubuque, Iowa : to joint committee representing Dubuque Commercial Club, Civic Division of Dubuque Woman's Club, and Trades and Labor Congress /

Mode of access: Internet.

Report on the effectiveness of financing and selected eligibility, job search, and benefit payment operations of the unemployment insurance program : State of Montana, Department of Labor and Industry, Employment Security Division.

Mode of access: Internet.

Report [of a conference sponsored by] Institute of Labor and Industrial Relations [and] Division of University Extension, University of Illinois. May 20-21, 1965.

Mode of access: Internet.

Fair Employment Practice Act (Chapter 121, Part 4.5, Division 2, Labor code) : FEPC rules and regulations : guide to pre-employment inquiries.

Cover title.

Labor laws governing the Division of Workshop and Factory Inspection /

Mode of access: Internet.

To create a Division of Safety in the Department of Labor : hearings before the Committee on Education and Labor, United States Senate, Sixty-ninth Congress, first session on S. 3983, a bill to create in the Bureau of Labor Statistics of the Department of Labor a Division of Safety.

Hearings held May 21 and June 2, 1926.

The sexual division of labor : the impact of organizational change upon group cohesion and the creation of occupational identity

The purpose of this research is to identify the impact of recent organizational change upon the culture of firefighting. The experiences of female firefighters were utilized as a measure of cultural change. A purposive sample of twenty-seven male and female firefighters were interviewed in a semi-structured format about their experiences in the fire service. This research found that the culture of firefighting has adjusted to the presence of previously excluded groups by forging a division among the identities and roles of male and female firefighters. The white, male firefighters, who have traditionally constituted a majority of the workforce, have continued to identify with traditional firefighter roles and reported high levels of cohesion. In contrast, the female firefighters showed a greater variance in their identification with traditional roles and decreased levels of cohesion with the main body of the group.

Analysis of Structure and Tendencies of Qualified Immigrant Workforce on the Swedish Labor Market

The purpose of this paper is to make quantitative and qualitative analysis of foreign citizens who may participate on the Swedish labor market (in text refers to as ‘immigrants’). This research covers the period 1973-2005 and gives prediction figures of immigrant population, age and gender structure, and education attainment in 2010. To cope with data regarding immigrants from different countries, the population was divided into six groups. The main chapter is divided into two parts. The first part specifies division of immigrants into groups by country of origin according to geographical, ethnical, economical and historical criteria. Brief characteristics and geographic position, dynamic and structure description were given for each group; historical review explain rapid changes in immigrant population. Statistical models for description and estimation future population were given. The second part specifies education and qualification level of the immigrants according to international and Swedish standards. Models for estimating age and gender structure, level of education and professional orientation of immigrants in different groups are given. Inferences were made regarding ethnic, gender and education structure of immigrants; the distribution of immigrants among Swedish counties is given. Discussion part presents the results of the research, gives perspectives for the future brief evaluation of the role of immigrants on the Swedish labor market.

Two stops in today's new global geographies: shaping novel labor supplies and employment regimes

Includes bibliography