REDUCTION OF CELL PROLIFERATIVE ACTIVITIES OF GASTRIC STUMP ADENOMATOUS HYPERPLASIAS AFTER BILE REFLUX DIVERSION IN RATS

Previously we reported the majority of lesions induced hy bile reflux, in the absence of chemical carcinogens, in the rat remnant stomach to consist primarily of gastric type and secondarily of intestinal type cells, and that they are reversible after diversion of bile reflux. The present study was designed to evaluate changes in proliferative activities in cells of each type under these conditions. The frequency of adenomatous hyperplasia (AH) induced in the gastric stump mucosa by duodenal content reflux after Billroth II partial gastrectomy (BII) increased until the 54th week of the experiment. Roux-en-Y (RY) surgical procedure which prevents duodenal reflux performed at the 24th or 36th week after BII led to a decrease in AH. Cell content of the lesions was analyzed using routine H&E staining, immunohistochemical staining for pepsinogen isoenzyme 1 and histochemical procedures for mucins (paradoxical concanavalin A, galactose oxidase Schiff and sialidase galactose oxidase Schiff reactions) and proliferation in each compartment evaluated by an immunohistochemical method using bromodeoxyuridine (BrdU) and a monoclonal antibody against BrdU. At the 54th week the number of BrdU-labeled cells per normal pyloric column was significantly (P < 0.05) increased to 10.63/pit after the BII operation, while it diminished to 5.23/pit after RY diversion, this being the same level as with the RY procedure alone. AH maintained a high rate of BrdU incorporation at 12.7% after BII operation, which was also significantly reduced (P < 0.01) to 7.0% by the RY surgery. The intestinal type cell showed highest (22.2%), the surface mucous type cell showed the next (16.5%) and the pyloric gland type cell showed lowest (5.2%) BrdU labeling indices after BII operation. All the cell types in AH showed similar proportional decreases in BrdU incorporation after RY diversion. Thus surgical intervention reverses the cell proliferation caused by bile reflux in the gastric stump.

On a regular convex solver potential for an elastic-damage constitutive model: a theoretical analysis

This work is related with the proposition of a so-called regular or convex solver potential to be used in numerical simulations involving a certain class of constitutive elastic-damage models. All the mathematical aspects involved are based on convex analysis, which is employed aiming a consistent variational formulation of the potential and its conjugate one. It is shown that the constitutive relations for the class of damage models here considered can be derived from the solver potentials by means of sub-differentials sets. The optimality conditions of the resulting minimisation problem represent in particular a linear complementarity problem. Finally, a simple example is present in order to illustrate the possible integration errors that can be generated when finite step analysis is performed. (C) 2003 Elsevier Ltd. All rights reserved.

A class of multiobjective control problems

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo comparativo do desempenho de rebolos com grãos superabrasivos e convencionais

Grinding is a precision machining process which is widely used in the manufacture of components requiring fine tolerances and smooth surfaces. There are several imput parameters (cutting conditions, cutting fluid and grinding wheel type used, dressing conditions etc.) which can affect the process variables (tangential and normal cutting forces, roughness, grinding temperatures, G ratio, etc.) leading to differences in the roughness, in the surface integrity and in the mechanical strength of the ground component. Consequently, the imput parameters must be controlled in order to insure the workpiece final quality. This paper presents a comparative evaluation of the performance of two types of grinding wheels [a conventional (Al2O3) and a superabrasive (CBN)] when grinding a VC131 steel, by the analysis of specific process variables when varying the cutting conditions. Highest values of G ratio and lowest workpiece roughness was observed when using CBN grinding wheels. This confirms the global trend of replacement of alumina grinding wheels by CBN, when grinding DTG (difficult to grind) materials.

A maximum principle for constrained infinite horizon dynamic control systems

This article presents and discusses a maximum principle for infinite horizon constrained optimal control problems with a cost functional depending on the state at the final time. The main feature of these optimality conditions is that, under reasonably weak assumptions, the multiplier is shown to satisfy a novel transversality condition at infinite time. It is also shown that these conditions can also be obtained for impulsive control problems whose dynamics are given by measure driven differential equations. © 2011 IFAC.

Estratégias para resolução do problema MPEC

Pós-graduação em Matemática - IBILCE

Análise ambiental de um aterro sanitário e sua influência relativa sobre a qualidade das águas superficiais do entorno

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Sistemas de manejo conservacionista do solo para cultivares de amendoim em sucessão à cana crua e pastagens

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Condições de otimidade para problemas de controle ótimo com condições de contorno funcionais

Pós-graduação em Matemática - IBILCE

A relaxed constant positive linear dependence constraint qualification and applications

In this work we introduce a relaxed version of the constant positive linear dependence constraint qualification (CPLD) that we call RCPLD. This development is inspired by a recent generalization of the constant rank constraint qualification by Minchenko and Stakhovski that was called RCRCQ. We show that RCPLD is enough to ensure the convergence of an augmented Lagrangian algorithm and that it asserts the validity of an error bound. We also provide proofs and counter-examples that show the relations of RCRCQ and RCPLD with other known constraint qualifications. In particular, RCPLD is strictly weaker than CPLD and RCRCQ, while still stronger than Abadie's constraint qualification. We also verify that the second order necessary optimality condition holds under RCRCQ.

TWO NEW WEAK CONSTRAINT QUALIFICATIONS AND APPLICATIONS

We present two new constraint qualifications (CQs) that are weaker than the recently introduced relaxed constant positive linear dependence (RCPLD) CQ. RCPLD is based on the assumption that many subsets of the gradients of the active constraints preserve positive linear dependence locally. A major open question was to identify the exact set of gradients whose properties had to be preserved locally and that would still work as a CQ. This is done in the first new CQ, which we call the constant rank of the subspace component (CRSC) CQ. This new CQ also preserves many of the good properties of RCPLD, such as local stability and the validity of an error bound. We also introduce an even weaker CQ, called the constant positive generator (CPG), which can replace RCPLD in the analysis of the global convergence of algorithms. We close this work by extending convergence results of algorithms belonging to all the main classes of nonlinear optimization methods: sequential quadratic programming, augmented Lagrangians, interior point algorithms, and inexact restoration.

Biochar characterization for its environmental and agricultural utilization. Occurrence, distribution and fate of labile organic carbon and polycyclic aromatic hydrocarbons

In this thesis the potential risks associated to the application of biochar in soil as well the stability of biochar were investigated. The study was focused on the potential risks arising from the occurrence of polycyclic aromatic hydrocarbons (PAHs) in biochar. An analytical method was developed for the determination of the 16 USEPA-PAHs in the original biochar and soil containing biochar. The method was successfully validated with a certified reference material for the soil matrix and compared with methods in use in other laboratories during a laboratory exercise within the EU-COST TD1107. The concentration of 16 USEPA-PAHs along with the 15 EU-PAHs, priority hazardous substances in food, was determined in a suite of currently available biochars for agricultural field applications derived from a variety of parent materials and pyrolysis conditions. Biochars analyzed contained the USEPA and some of the EU-PAHs at detectable levels ranging from 1.2 to 19 µg g-1. This method allowed investigating changes in PAH content and distribution in a four years study following biochar addition in soils in a vineyard (CNR-IBIMET). The results showed that biochar addition determined an increase of the amount of PAHs. However, the levels of PAHs in the soil remained within the maximum acceptable concentration for European countries. The vineyard soil performed by CNR-IBIMET was exploited to study the environmental stability of biochar and its impact on soil organic carbon. The stability of biochar was investigated by analytical pyrolysis (Py-GC-MS) and pyrolysis in the presence of hydrogen (HyPy). The findings showed that biochar amendment significantly influence soil stable carbon fraction concentration during the incubation period. Moreover, HyPy and Py-GC-MS were applied to biochars deriving from three different feedstock at two different pyrolysis temperatures. The results evidenced the influence of feedstock type and pyrolysis conditions on the degree of carbonisation.

QUADRUPOLE LEVITATION OF PARTICLES IN A THERMODYNAMICALLY REALISTIC CLOUD ENVIRONMENT

Understanding clouds and their role in climate depends in part on our ability to understand how individual cloud particles respond to environmental conditions. Keeping this objective in mind, a quadrupole trap with thermodynamic control has been designed and constructed in order to create an environment conducive to studying clouds in the laboratory. The quadrupole trap allows a single cloud particle to be suspended for long times. The temperature and water vapor saturation ratio near the trapped particle is controlled by the flow of saturated air through a tube with a discontinuous wall temperature. The design has the unique aspect that the quadrupole electrodes are submerged in heat transfer fluid, completely isolated from the cylindrical levitation volume. This fluid is used in the thermodynamic system to cool the chamber to realistic cloud temperatures, and a heated section of the tube provides for the temperature discontinuity. Thus far, charged water droplets, ranging from about 30-70 microns in diameter have been levitated. In addition, the thermodynamic system has been shown to create the necessary thermal conditions that will create supersaturated conditions in subsequent experiments. These advances will help lead to the next generation of ice nucleation experiments, moving from hemispherical droplets on a substrate to a spherical droplet that is not in contact with any surface.

Different Land Use Intensities in Grassland Ecosystems Drive Ecology of Microbial Communities Involved in Nitrogen Turnover in Soil

Understanding factors driving the ecology of N cycling microbial communities is of central importance for sustainable land use. In this study we report changes of abundance of denitrifiers, nitrifiers and nitrogen-fixing microorganisms (based on qPCR data for selected functional genes) in response to different land use intensity levels and the consequences for potential turnover rates. We investigated selected grassland sites being comparable with respect to soil type and climatic conditions, which have been continuously treated for many years as intensely used meadows (IM), intensely used mown pastures (IP) and extensively used pastures (EP), respectively. The obtained data were linked to above ground biodiversity pattern as well as water extractable fractions of nitrogen and carbon in soil. Shifts in land use intensity changed plant community composition from systems dominated by s-strategists in extensive managed grasslands to c-strategist dominated communities in intensive managed grasslands. Along the different types of land use intensity, the availability of inorganic nitrogen regulated the abundance of bacterial and archaeal ammonia oxidizers. In contrast, the amount of dissolved organic nitrogen determined the abundance of denitrifiers (nirS and nirK). The high abundance of nifH carrying bacteria at intensive managed sites gave evidence that the amounts of substrates as energy source outcompete the high availability of inorganic nitrogen in these sites. Overall, we revealed that abundance and function of microorganisms involved in key processes of inorganic N cycling (nitrification, denitrification and N fixation) might be independently regulated by different abiotic and biotic factors in response to land use intensity.

Voces en un campo de sangre : Max Aub y los penúltimos episodios nacionales

Una cierta lectura de la posmodernidad ha diagnosticado (en realidad, ofertado) el final de la historia y, por consiguiente, el de la novela histórica, aunque algunos optamos por no enterrarla sino por renovarla. En el contexto de este debate vale la pena detenerse en el Laberinto mágico de Max Aub, magno mural de la guerra civil española, una de las últimas manifestaciones del modelo puro de episodio nacional, máximo legado de Galdós y Valle Inclán. A pesar de los elementos aparentemente heterogéneos que contiene, el gesto histórico e ideológico que traza Campo cerrado (escrita en 1939), la primera novela del Laberinto mágico, es el de la novela histórica moderna. En los Campos posteriores, la fórmula de la novela histórica aubiana alcanzará su sazón, siendo quizá Campo del moro (1963) el más brillante y equilibrado ejemplo de esta modalidad entre las de la serie. En ella, el sentido de la historia que se anunciaba en Campo del moro se disipa, víctima de la traición y asaltado por la locura que se desata en las calles de Madrid. Campo del moro puede considerarse novela histórica pura, ya que se cumplen en ella las condiciones de felicidad necesarias para que esta modalidad genérica se realice plenamente: historicidad de los acontecimientos; respeto al orden cronológico en que se suceden; ficcionalidad limitada por el referente histórico; iniciativa de lo histórico sobre lo ficcional y primacía de la lógica de lo público sobre la de lo privado; por último, narratibilidad de los acontecimientos que se manifiesta en la selección del golpe de estado de Casado y Besteiro y su potenciación como clave del relato histórico. Tres grandes temas se despliegan en la lógica argumental de la novela: la traición, la confusión del laberinto y la degradación de una causa heroica. En el discurso de Max Aub que alimenta la novela, la ficción, la verdad y la historia se entrelazan hasta formar el hilo de Ariadna en el Laberinto.