Third party assessments in trust problems with conflict of interest: An experiment on the effects of promisesm

Is it possible to elicit reliable assessment from an assessor having a conflict of interest (e.g. a professor that writes a recommendation letter for a formal PhD student)? We propose an experimental test and show that compared to a not-incentivized assessment, a promise to give a truthful assessment reduces misreporting to the same extent as an incentivized assessment (i.e. when the assessor gains higher payoff if the assessment is correct).

Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress

REV3, the catalytic subunit of translesion polymerase zeta (polζ), is commonly associated with DNA damage bypass and repair. Despite sharing accessory subunits with replicative polymerase δ, very little is known about the role of polζ in DNA replication. We previously demonstrated that inhibition of REV3 expression induces persistent DNA damage and growth arrest in cancer cells. To reveal determinants of this sensitivity and obtain insights into the cellular function of REV3, we performed whole human genome RNAi library screens aimed at identification of synthetic lethal interactions with REV3 in A549 lung cancer cells. The top confirmed hit was RRM1, the large subunit of ribonucleotide reductase (RNR), a critical enzyme of de novo nucleotide synthesis. Treatment with the RNR-inhibitor hydroxyurea (HU) synergistically increased the fraction of REV3-deficient cells containing single stranded DNA (ssDNA) as indicated by an increase in replication protein A (RPA). However, this increase was not accompanied by accumulation of the DNA damage marker γH2AX suggesting a role of REV3 in counteracting HU-induced replication stress (RS). Consistent with a role of REV3 in DNA replication, increased RPA staining was confined to HU-treated S-phase cells. Additionally, we found genes related to RS to be significantly enriched among the top hits of the synthetic sickness/lethality (SSL) screen further corroborating the importance of REV3 for DNA replication under conditions of RS.

The Psychological Outcome of Religious Coping with Stressful Life Events in a Swiss Sample of Church Attendees

Background: Recent research suggested thatreligious coping, based on dispositional religiousness and spirituality (R/S), is an important modulating factor in the process of dealing with adversity. In contrast to the United States, the effect of R/S on psychological adjustment to stress is a widely unexplored area in Europe. Methods: We examined a Swiss sample of 328 church attendees in the aftermath of stressful life events to explore associations of positive or negative religious coping with the psychological outcome. Applying a cross-sectional design, we used Huber’s Centrality Scale to specify religiousness and Pargament’s measure of religious coping (RCOPE) for the assessment of positive and negative religious coping. Depressive symptoms and anxiety as outcome variables were examined by the Brief Symptom Inventory. The Stress-Related Growth Scale and the Marburg questionnaire for the assessment of well-being were used to assess positive outcome aspects. We conducted Mann-Whitney tests for group comparisons and cumulative logit analysis for the assessmentof associations of religious coping with our outcome variables. Results: Both forms of religious coping were positively associated with stress-related growth (p < 0.01). However, negative religious coping additionally reduced well-being (p = 0.05, β = 0.52, 95% CI = 0.27–0.99) and increased anxiety (p = 0.02, β = 1.94, 95% CI = 1.10–3.39) and depressive symptoms (p = 0.01, β = 2.27, 95% CI = 1.27–4.06). Conclusions: The effects of religious coping on the psychological adjustment to stressful life events seem relevant. These findings should be confirmed in prospective studies.

The Proper Generalized Decomposition With Application In Problems Of Dynamics

In this paper we address the new reduction method called Proper Generalized Decomposition (PGD) which is a discretization technique based on the use of separated representation of the unknown fields, specially well suited for solving multidimensional parametric equations. In this case, it is applied to the solution of dynamics problems. We will focus on the dynamic analysis of an one-dimensional rod with a unit harmonic load of frequency (ω) applied at a point of interest. In what follows, we will present the application of the methodology PGD to the problem in order to approximate the displacement field as the sum of the separated functions. We will consider as new variables of the problem, parameters models associated with the characteristic of the materials, in addition to the frequency. Finally, the quality of the results will be assessed based on an example.

The migratory farm labor problem in the United States : a report, together with individual views, to the Committee on Labor and Public Welfare, United States Senate, made by its Subcommittee on Migratory Labor, pursuant to S. Res. 267 (86th Cong., 2d sess.) a resolution authorizing a study of the problems of migratory labor.

Cover title.

The complete confectioner, or, Housekeeper's guide to a simple and speedy method of understanding the whole art of confectionary : the various ways of preserving and candying, dry and liquid, all kinds of fruit, nuts, flowers, herbs, &c. And the method of keeping them fresh and fine all the year round; the different ways of clarifying sugar; with directions for making fruit pastes, bomboons, pastils, compotes, fruit ices, cream ices, marmalades, jellies, jams, cakes, puffs, biscuits, tarts, custards, cheesecakes, sweetmeats, fritters, creams, syllabubs, blanc-mange, flummeries, ornaments for grand entertainments, dragees, syrups of all kinds, nicknacks and trifles for desserts, strong cordials, oils, simple waters, milk punch that will keep 20 years, and all sorts of English wines. Also, the art of making artificial fruit, with the stalks in it, so as to resemble the natural fruit. To which are added, some bills of fare for desserts for private families /

Originally published under title: The compleat confectioner. Cf. Bitting, K.G. Gastronomic bib., p. 190.

Coping with eldercare [microform] : a growing challenge in the workplace : hearing before a subcommittee of the Committee on Government Operations, House of Representatives, One Hundredth Congress, second session, October 28, 1988.

CIS Microfiche Accession Numbers: CIS 89 H401-23

The major range problems and their solution, résumé of a report prepared in response to Senate resolution 29, together with letters of transmittal, table of contents, etc., from "The western range,a great but neglected natural resource,"

Mode of access: Internet.

The light of the Cross in the Twentieth Century : the influence of the Church on modern civilization, her treatment of the great moral and social problems of our time, by master minds, the foundations, history and progress of her great educational institutions in the United States, her great religious orders of men and women for spreading the Gospel and teaching secular and religious knowledge, the history of the organization, development and aims of the great Catholic fraternal societies of the United States and their national federation with many other important subjects, the teachings of the Church made manifest to the modern mind /

Contents: v. 3. The glorious teachings of our holy religion

Compliance problems of small utility systems with the Powerplant and Industrial Fuel Use Act of 1978.

"DOE/RG-0045."