Welland Canal Survey of Lands John Brown, 1827

Survey map and description of John Brown's land created by The Welland Canal Company. Included is a written description of the land along with a drawing of the land. Noteable features include; Welland river, towpath, canal, lock, side line between Broan and Carl. The land totals 6 acres, 3 roads and 33 perches. The deed for the land is dated April 2, 1827. Surveyor notes are seen in pencil on the map.

Printed Blank by which John Brown Cullen solemnly declares that he is experienced in the art of measuring and culling timber

Printed blank by which John Brown Cullen solemnly declares that he is experienced in the art of measuring and culling timber. He states that he is entering into the service of Burton and Bro. of Barrie He will make out the specification of the timber in berths 192 and 198 and submit his findings to Burton and Brother, Oct. 22, 1877.

Declaration from John Brown, culler who states that there are 1167 pieces which equal 75704 cubic feet of timber to be culled

Declaration from John Brown, culler who states that there are 1167 pieces which equal 75704 cubic feet of timber to be culled, April 9, 1878.

Note that John Brown has done grading in the section between Geneva Street and Slabtown [known as Merritton prior to amalgamation with St. Catharines in 1961]

Note that John Brown has done grading in the section between Geneva Street and Slabtown [known as Merritton prior to amalgamation with St. Catharines in 1961]. This document is badly stained and faded. It is signed by S.D. Woodruff, 1855.

Note that John Brown has graveled in the section between Geneva Street and Slabtown

Note that John Brown has graveled in the section between Geneva Street and Slabtown. This is signed by S.D. Woodruff, Oct. 18, 1855.

Note stating that John Brown has done grading in the section of railway between Geneva Street and Slabtown

Note stating that John Brown has done grading in the section of railway between Geneva Street and Slabtown. This document is signed by S.D. Woodruff, Dec. 12, 1855.

Chart of estimate for work done on the Port Dalhousie and Thorold Railway by John Brown

Chart of estimate for work done on the Port Dalhousie and Thorold Railway by John Brown, contractor regarding the section between Geneva Street and the Thorold Station up to the 30th of June 1856. This document is burned on the edges. This does not affect the text, 1856

Port Dalhousie and Thorold Railway wages paid to John Brown

Port Dalhousie and Thorold Railway wages paid to John Brown (2 pages, handwritten) from Aug. 1855 – May 1856.

Receipt from John Brown, contractor of Thorold, Ontario

Receipt from John Brown, contractor of Thorold, Ontario for cement, Aug. 8, 1876.

Tratamiento de Artritis reumatoide con antagonistas del factor de necrosis tumoral alfa y su asociación con el desarrollo de melanoma cutáneo: revisión sistemática de la literatura y meta-análisis.

Introducción: El tratamiento con antagonistas del factor de necrosis tumoral alfa (anti TNF) ha impactado el pronóstico y la calidad de vida de los pacientes con artritis reumatoide (AR) positivamente, sin embargo, se interroga un incremento en el riesgo de desarrollar melanoma. Objetivo: Conocer la asociación entre el uso de anti TNF y el desarrollo de melanoma maligno en pacientes con AR. Metodología: Se realizó una búsqueda sistemática en MEDLINE, EMBASE, COCHRANE LIBRARY y LILACS para ensayos clínicos, estudios observacionales, revisiones y meta-análisis en pacientes adultos con diagnóstico de AR y manejo con anti TNF (Certolizumab pegol, Adalimumab, Etanercept, Infliximab y Golimumab). Resultados: 37 estudios clínicos cumplieron los criterios de inclusión para el meta-análisis, con una población de 16567 pacientes. El análisis de heterogeneidad no fue significativo (p=1), no se encontró diferencia en el riesgo entre los grupos comparados DR -0.00 (IC 95% -0.001; -0.001). Un análisis adicional de los estudios en los que se reportó al menos 1 caso de melanoma (4222 pacientes) tampoco mostró diferencia en el riesgo DR -0.00 (IC 95% -0.004 ; -0.003). Conclusión: En la evidencia disponible a la fecha no encontramos asociación significativa entre el tratamiento con anti TNF en pacientes con diagnóstico de AR y el desarrollo de melanoma cutáneo.