Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression

The objective of the present study was to develop a quantitative method to evaluate laser-induced choroidal neovascularization (CNV) in a rat model using Heidelberg Retina Angiograph 2 (HRA2) imaging. The expression of two heparan sulfate proteoglycans (HSPG) related to inflammation and angiogenesis was also investigated. CNV lesions were induced with argon laser in 21 heterozygous Zucker rats and after three weeks a fluorescein angiogram and autofluorescence exams were performed using HRA2. The area and greatest linear dimension were measured by two observers not aware of the protocol. Bland-Altman plots showed agreement between the observers, suggesting that the technique was reproducible. After fluorescein angiogram, HSPG (perlecan and syndecan-4) were analyzed by real-time RT-PCR and immunohistochemistry. There was a significant increase in the expression of perlecan and syndecan-4 (P < 0.0001) in retinas bearing CNV lesions compared to control retinas. The expression of these two HSPG increased with increasing CNV area. Immunohistochemistry demonstrated that the rat retina damaged with laser shots presented increased expression of perlecan and syndecan-4. Moreover, we observed that the overexpression occurred in the outer layer of the retina, which is related to choroidal damage. It was possible to develop a standardized quantitative method to evaluate CNV in a rat model using HRA2. In addition, we presented data indicating that the expression of HSPG parallels the area of CNV lesion. The understanding of these events offers opportunities for studies of new therapeutic interventions targeting these HSPG.

Efecto del pH y de la adición de fosfatos de sodio sobre las propiedades de gelificación y emulsión de surimi de trucha arco-iris (Oncorhynchus mykiss)

Para la elaboración de surimi se han empleado distintas técnicas, sin embargo, es indispensable mantener la funcionalidad de las proteínas musculares durante su extracción, ya que son afectadas principalmente por el pH. La incorporación de fosfatos en productos cárnicos afecta el pH, teniendo como consecuencia una mejora en la capacidad de retención de agua de las proteínas musculares, alterando la funcionalidad de estos productos. Se utilizó la metodología de superficie de respuesta para determinar el efecto de cinco niveles de pH y cinco concentraciones de una mezcla de fosfatos de sodio comercial sobre la funcionalidad de surimi de trucha arco-iris, evaluada por su capacidad de emulsión y trabajo de emulsión, fuerza de gel y trabajo de penetración de geles de surimi. Los resultados obtenidos indican que el incremento en la concentración de fosfatos de sodio mejoró la funcionalidad del surimi y a pH alcalino las propiedades de emulsión mejoraron, pero se afectaron negativamente las propiedades de gelificación.

Photograph of Richard, Iris and Albert Sloman [n.d.]

An undated photograph of Richard, Iris and Albert Sloman taken outside what is believed to be a holiday cabin in Parry Sound, Ontario. This photograph was in the possession of the Rick Bell family, of St. Catharines.

Richard Nelson Bell - Iris Sloman Wedding Day Photo, 1939

A black and white photograph taken in 1939 on the occasion of the marriage of Richard Nelson Bell to Iris Sloman. Pictured in the photograph, from left to right, are: Bert Sloman; Richard Nelson Bell; Iris Sloman Bell; and Helen Beatty Sloman. This photograph was in the possession of Rick Bell, the son of Richard Nelson and Iris Bell. The Bell - Sloman family descends from former Black slaves from the United States.Bert Sloman (Albert Edward Sloman) passed away in 1986 at Kitchener-Waterloo, Ontario. His wife Vera Matilda Sloman passed away January 4, 2011 at Cambridge Memorial Hospital. They had a son, Ron Sloman.

Albert, Josie and Iris Sloman in the Vegetable Garden [ n.d.]

This undated black and white family snapshot shows Albert and Josie Sloman (at left) with their daughter, Iris Sloman Bell (third from left) and an unidentified woman in the vegetable garden. The location of the garden is not clear, although it could be St. Catharines or London, Ontario. This photograph was in the possession of Rick Bell, of St. Catharines, whose mother was Iris Sloman Bell. The Sloman - Bell family ancestry includes former Black slaves from the United States who settled in Canada.

Iris Sloman with unidentified woman and sister Helen Sloman [n.d.]

Iris Sloman, at left, with her sister, Helen, far right, and an unidentified woman on the beach in this undated photo. The location could possibly be Port Dalhousie or Parry Sound. This photo was among the family memorabilia retrieved by Rick Bell from his mother's attic in St. Catharines in the 1980s. The Bell - Sloman family descends from former African American slaves who settled in the London and St. Catharines areas.

Richard and Iris Bell Wedding Day, 1939

Richard and Iris (Sloman) Bell are pictured on the grounds of unknown gardens, possibly in Niagara Falls, on their wedding day in 1939. This photo was among the family memorabilia in the possession of their son, Rick Bell, of St. Catharines.

Iris Sloman [n.d.]

A young Iris Sloman is pictured in this portrait, date and location unknown. Iris Sloman married Richard Bell in 1939 and the couple resided in St. Catharines, Ontario. Her son, Rick Bell, retrieve this and other family photos from his mother's attic in the 1980s. Branches of the Bell -Sloman family are descended from African American slaves.

Vera Sloman, Richard Bell, Iris Sloman Bell and Bert Sloman [n.d.]

This black and white family photo is undated yet believed to be in 1939 on the wedding day of Richard and Iris Bell. Pictured in this photo are, from right, Vera, Richard Bell, Iris Sloman Bell, and Bert Sloman. This photo was in the possession of Rick Bell, of St. Catharines, son of Richard and Iris. The Bell - Sloman families have descendants who are former African American slaves.Bert Sloman (Albert Edward Sloman) passed away in 1986 at Kitchener - Waterloo, Ontario. His wife, Vera Matilda Sloman, passed away January 4, 2011 at Cambridge Memorial Hospital. They had a son, Ron Sloman.

Arco iris de paz, cuya cuerda es la consideración y meditación para rezar el Santisimo Rosario de Nuestra Señora : su aljaba ocupa quinientas y setenta concideraciones que tira el amor divino a todas las almas...

UANL

Lessons in english literature with a short dictionary of bristish, iris, and american autors

UANL

Public Reason that Speaks to People : Iris Marion Young and the Problem of Internal Exclusion

Dossier : In Memoriam, Iris Marion Young (1949-2006)

Effectiveness Of Feature Detection Operators On The Performance Of Iris Biometric Recognition System

Iris Recognition is a highly efficient biometric identification system with great possibilities for future in the security systems area.Its robustness and unobtrusiveness, as opposed tomost of the currently deployed systems, make it a good candidate to replace most of thesecurity systems around. By making use of the distinctiveness of iris patterns, iris recognition systems obtain a unique mapping for each person. Identification of this person is possible by applying appropriate matching algorithm.In this paper, Daugman’s Rubber Sheet model is employed for irisnormalization and unwrapping, descriptive statistical analysis of different feature detection operators is performed, features extracted is encoded using Haar wavelets and for classification hammingdistance as a matching algorithm is used. The system was tested on the UBIRIS database. The edge detection algorithm, Canny, is found to be the best one to extract most of the iris texture. The success rate of feature detection using canny is 81%, False Accept Rate is 9% and False Reject Rate is 10%.

IRIS BIOMETRIC RECOGNITION SYSTEM EMPLOYING CANNY OPERATOR

Biometrics has become important in security applications. In comparison with many other biometric features, iris recognition has very high recognition accuracy because it depends on iris which is located in a place that still stable throughout human life and the probability to find two identical iris's is close to zero. The identification system consists of several stages including segmentation stage which is the most serious and critical one. The current segmentation methods still have limitation in localizing the iris due to circular shape consideration of the pupil. In this research, Daugman method is done to investigate the segmentation techniques. Eyelid detection is another step that has been included in this study as a part of segmentation stage to localize the iris accurately and remove unwanted area that might be included. The obtained iris region is encoded using haar wavelets to construct the iris code, which contains the most discriminating feature in the iris pattern. Hamming distance is used for comparison of iris templates in the recognition stage. The dataset which is used for the study is UBIRIS database. A comparative study of different edge detector operator is performed. It is observed that canny operator is best suited to extract most of the edges to generate the iris code for comparison. Recognition rate of 89% and rejection rate of 95% is achieved

La ciudad de Arco Iris : un espacio para aprender, jugar e investigar.

Resumen tomado de la publicación