Library and IT Staff Presentations and Publications: Spring 2012

Library and IT Staff presented and published many innovative works of scholarship in the past year.

From the Vice President for Library and Information Technology: Spring 2012

Param Bedi discusses technology adoption by students and its impact on teaching and learning.

The James Lind Library: explaining and illustrating the evolution of fair tests of medical treatments

The James Lind Library (www.jameslindlibrary.org) has been established to improve public and professional general knowledge about fair tests of treatments in healthcare and their history. Its foundation was laid ten years ago at the Royal College of Physicians of Edinburgh, and its administrative centre is in the College's Sibbald Library, one of the most important collections of historic medical manuscripts, papers and books in the world. The James Lind Library is a website that introduces visitors to the principles of fair tests of treatments, with a series of short, illustrated essays, which are currently available in English, Arabic, Chinese, French, Portuguese, Russian and Spanish. A 100-page book-- Testing Treatments--is now available free through the website, both in English and in Arabic and Spanish translations. To illustrate the evolution of ideas related to fair tests of treatments from 2000 BC to the present, the James Lind Library contains key passages and images from manuscripts, books and journal articles, many of them accompanied by commentaries, biographies, portraits and other relevant documents and images, including audio and video files. New material is being added to the website continuously, as relevant new records are identified and as methods for testing treatments evolve. A multinational, multilingual editorial team oversees the development of the website, which currently receives tens of thousands of visitors every month.

PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus

We have used a combination of computerized database mining and experimental expression analyses to identify a gene that is preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus, and placenta, as well as in prostate cancer, testicular cancer, and uterine cancer. This gene is located on the human X chromosome, and it is homologous to a family of genes encoding GAGE-like proteins. GAGE proteins are expressed in a variety of tumors and in testis. We designate the novel gene PAGE-1 because the expression pattern in the Cancer Genome Anatomy Project libraries indicates that it is predominantly expressed in normal and neoplastic prostate. Further database analysis indicates the presence of other genes with high homology to PAGE-1, which were found in cDNA libraries derived from testis, pooled libraries (with testis), and in a germ cell tumor library. The expression of PAGE-1 in normal and malignant prostate, testicular, and uterine tissues makes it a possible target for the diagnosis and possibly for the vaccine-based therapy of neoplasms of prostate, testis, and uterus.

Letter from William Croswell to John C. Page, 1811 December 24

Draft of a one-page letter regarding Page's financial assistance to Croswell in Liverpool, with a laid-in leaf containing an accounting statement.

Plan for the arrangement of the catalogue of the University Library, [1817 January]

Six-page handwritten draft of an organization plan for the catalogue of the Harvard University Library.

Library record,

A torn manuscript page listing members' library accounts.

[Library charging records, 1782]

This four-page undated list contains volume titles followed by the surname of Harvard faculty and students and presumably documents book borrowing from the College Library. The list is undated but notes members of the Harvard Class of 1782 as seniors.

Page of diary, Jan. 1-4, 1800

Contains very brief entries from the first four days of January. Verso contains numerical calculations labeled as "Recital del case from Oct. 1, [17]99."

Diary of John Page, 1757-1781

Manuscript volume. The first thirty-nine pages include diary entries from Page's years as an undergraduate student at Harvard College. Dated July 1757 through March 1761, entries includes short notes about daily activities. Topics covered include expenses, academics, clothing, and travel to and from Cambridge. Twenty-two pages covering 1764 through 1781 contain brief listings of items, generally foodstuffs, received from male and female Danville parishioners identified by name in Danville. The final twenty-six pages contain notes listing area deaths, as well as his own thoughts on topics such as "of light" and "jealousy." The concluding pages include rules "Concerning Grammar."