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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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BACKGROUND: While detoxification under anaesthesia accelerates the detoxification procedure, there is a lack of randomised clinical trials evaluating its effectiveness compared to traditional detoxification procedures, and a lack of data on long-term abstinence. METHODS: Prospective randomised clinical trial. Analysis by intention to treat and per protocol. Setting: Specialised substance abuse unit in a psychiatric teaching hospital and an intensive care unit of a general hospital. Participants: Seventy patients with opiate mono-dependence requesting detoxification: 36 randomised to RODA (treatment as allocated received by 26) and 34 randomised to classical clonidine detoxification (treatment as allocated received by 21). Main outcome measures: Successful detoxification, safety and self-reported abstinence at 3, 6 and 12 months after detoxification. RESULTS: Socio-demographics were similar in both groups at baseline. No complications were reported during or after anaesthesia. According to the intention to treat analysis, 28/36 (78%) RODA patients and 21/34 (62%) of the clonidine group successfully completed the detoxification process (p=0.14). In the intention to treat analysis, 30% of RODA patients were abstinent after 3 months compared to 14% in the clonidine group (p=0.11). No difference was found at 6 and 12 months (both groups showed less than 5% abstinence after 12 months). The per-protocol analysis showed similar results with no statistical differences either for ASI mean scores or for the SF36 questionnaire. CONCLUSION: Although the detoxification success rate and abstinence after 3 months were slightly better for the RODA procedure compared to clonidine treatment, these differences were not statistically significant and disappeared completely after 6 and 12 months.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.

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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.