The natural history of self-harm from adolescence to young adulthood : a population-based cohort study

Background Knowledge about the natural history of self-harm is scarce, especially during the transition from adolescence to young adulthood, a period characterised by a sharp rise in self-inflicted deaths. From a repeated measures cohort of a representative sample, we describe the course of self-harm from middle adolescence to young adulthood.

Methods A stratified, random sample of 1943 adolescents was recruited from 44 schools across the state of Victoria, Australia, between August, 1992, and January, 2008. We obtained data pertaining to self-harm from questionnaires and telephone interviews at seven waves of follow-up, commencing at mean age 15·9 years (SD 0·49) and ending at mean age 29·0 years (SD 0·59). Summary adolescent measures (waves three to six) were obtained for cannabis use, cigarette smoking, high-risk alcohol use, depression and anxiety, antisocial behaviour and parental separation or divorce.

Findings 1802 participants responded in the adolescent phase, with 149 (8%) reporting self-harm, More girls (95/947 [10%]) than boys (54/855 [6%]) reported self-harm (risk ratio 1·6, 95% CI 1·2–2·2). We recorded a substantial reduction in the frequency of self-harm during late adolescence. 122 of 1652 (7%) participants who reported self-harm during adolescence reported no further self-harm in young adulthood, with a stronger continuity in girls (13/888) than boys (1/764). During adolescence, incident self-harm was independently associated with symptoms of depression and anxiety (HR 3·7, 95% CI 2·4–5·9), antisocial behaviour (1·9, 1·1–3·4), high-risk alcohol use (2·1, 1·2–3·7), cannabis use (2·4, 1·4–4·4), and cigarette smoking (1·8, 1·0–3·1). Adolescent symptoms of depression and anxiety were clearly associated with incident self-harm in young adulthood (5·9, 2·2–16).

Interpretation Most self-harming behaviour in adolescents resolves spontaneously. The early detection and treatment of common mental disorders during adolescence might constitute an important and hitherto unrecognised component of suicide prevention in young adults.

Funding National Health and Medical Research Council, Australia, and operational infrastructure support programme, Government of Victoria, Australia.

A short critical history of the application of genomics to animal breeding

Two scientific schools have been in coexistence from the beginning of genetics, one of them searching for factors of inheritance and the other one applying biometrical models to study the relationships between relatives. With the development of molecular genetics, the possibilities of detecting genes having a noticeable effect in traits augmented. Some genes with large or medium effects were localized in animals, although the most common result was to detect markers linked to these genes, allowing the possibility of assisting selection programs with markers. When a large amount of simple and inexpensive markers were available, the SNPs, new possibilities were opened since they did not need the presence of genes of large or medium effect controlling a trait, because the whole genome was scanned. Using a large amount of SNPs permits having a prediction of the breeding value at birth accurate enough to be used in some cases, like dairy cattle, to halve its generation interval. In other animal breeding programs, the implementation of genomic selection is less clear and the way in which it can be useful should be carefully studied. The need for large populations for associating phenotypic data and markers, plus the need for repeating the process continuously, complicates its application in some cases. The implementation of the information provided by the SNPs in current genetic programs has led to the development of complex statistical tools, joining the efforts of the two schools, factorial and biometrical, that nowadays work closely related.

Burke's genealogical and heraldic history of peerage, baronetage and knightage.

Accompanied by "War gazette and corrigenda" and "Burke's approved list of recommended schools, " 1940-

A History of education in Michigan

Vol. 4 edited by W. Wichers, has imprint: Detroit, Wayne State University Press

A history of painting in Italy : Umbria, Florence and Siena from the second to the sixteenth century /

"Biographies of the authors": v. 1, p. ix-xviii.

Commentaries on the Constitution of the United States : with a preliminary review of the constitutional history of the colonies and states, before the adoption of the Constitution /

Includes index.

History of Princeton and its institutions /

Subtitle: The town from its first settlement, through the Revolutionary War, to the present time : its churches, schools, college, theological seminary, literature, volumes and authors, notices of prominent families, and chief citizens, the cemetery, etc.

History of America /

Published also as: History of the United States. c1876. (Freeman's historical course for schools ; 6).

The history of South Carolina /

Includes index.

The historical reader, designed for use of schools and families. On a new plan.

Mode of access: Internet.

Second class book : principally consisting of historical, geographical, and biographical lessons : adapted to the capacities of youth, and designed for their improvement : intended for the use of schools /

Mode of access: Internet.

The history of painting in Italy, from the period of the revival of the fine arts to the end of the eighteenth century;

Vol. 1: 1888; v.2: 1887; v.3: 1854.

History of the dental college of the University of Michigan /

Endnote on p. 25-26 (reference from p. 3): description of the bill to appropriate state funds for the establishment of the dental college at the University of Michigan.

History of intellectual development : on the lines of modern evolution /

v. 1. Greek and Hindoo thought; Graeco-Roman paganism; Judaism; and the closing of the schools of Athens by Justinian (1912) --v.3. Political; Educational; Social; including an attempted reconstruction of the politics of England, France and America for the twentieth century (1901).