Montesquieu, Rousseau, Herder. De las teorías climáticas a la voz del pueblo como factor constitutivo

This article shows in which way the so-called climate theories, which have been developed since Antiquity, change over the course of time and influence the different theories on the origin of language. Via Montesquieu and Rousseau, the “climate theories” have influenced Johann Gottfried Herder, who bases on the romantic concept of Volk. By this means, a lot of ideas come into being which are fundamental for the foundation and development of the national philologies in Europe.

Johann Gottfried von Herder's Erläuterungen zum Neuen Testament aus einer neueröfneten morgenländischen quelle. 1775 ...

"Briefe zweener brüder Jesu in unserem kanon": p. [183]-211.

Filosofía de la finitud Joan-Carles Mèlich Barcelona: Herder, 2002

Los mismos pasos que la escritura va marcando mien­tras se propone la semblanza del pensamiento empiezan a difuminarse como un pasado en riesgo de ser desmentido por el presente. La temporalidad de la existencia se cumple en actos ininterrumpidos que alteran lo que puede ser con­cebido como esencia. El espacio también es en el tiempo, así como los cuerpos y fenómenos que construyen los paisajes de la realidad en la cual habitamos. Pero habitar no significa corresponder con lo habitual del espacio, del tiempo, los acontecimientos y las circunstancias. Habitar es construir la vida en herme­néutica con la finitud, reinventándonos en la obra humana; en la escultura del lenguaje, de la narración; en el asombro por las nuevas facetas e identidades que logramos y abandonamos sin vestigios de apego.

La philosophie face au public : Kant, Herder et la Popularphilosophie

La pénétration en Allemagne des philosophies des lumières françaises et écossaises concorde avec l’émergence de la Popularphilosophie. Ce courant, prenant conscience de la place de la philosophie dans la société, suscite un repositionnement du discours philosophique en l’envisageant comme s’exerçant publiquement. Cet article se propose d’examiner certaines conséquences de cette mutation par le prisme d’un débat entre deux philosophes : Kant et Herder. Tous deux inspirés par l’Aufklärung, leurs conceptions de l’articulation entre raison et langage les mènent pourtant dans deux directions opposées : vers l’universalité et la clarté avec Kant ou vers le particularisme et l’expressivité avec Herder.

La philosophie face au public : Kant, Herder et la Popularphilosophie

La pénétration en Allemagne des philosophies des lumières françaises et écossaises concorde avec l’émergence de la Popularphilosophie. Ce courant, prenant conscience de la place de la philosophie dans la société, suscite un repositionnement du discours philosophique en l’envisageant comme s’exerçant publiquement. Cet article se propose d’examiner certaines conséquences de cette mutation par le prisme d’un débat entre deux philosophes : Kant et Herder. Tous deux inspirés par l’Aufklärung, leurs conceptions de l’articulation entre raison et langage les mènent pourtant dans deux directions opposées : vers l’universalité et la clarté avec Kant ou vers le particularisme et l’expressivité avec Herder.

Viajar é preciso: Theodor Koch-Grünberg e a Völkerkunde alemã do século XIX

Tomando a etnografia de Theodor Koch-Grünberg como realização ideal do projeto científico da Völkerkunde (antropologia) alemã desde a sua invenção por Waitz e, principalmente, Adolf Bastian, até a sua auto-eliminação nos primórdios do Terceiro Reich, analisamos inicialmente as raízes desse projeto na filosofia alemã, desde Herder até a ruptura neokantiana entre as ciências naturais e sociais (ou culturais) na metade do século XIX. Em seguida mostramos que, transformados em programa etnográfico, os pressupostos epistêmicos da Völkerkunde eram, desde o início, condenados ao fracasso, não obstante os heróicos esforços como este de Koch-Grünberg.

Uma filosofia da cultura prospectiva da hiper-modernidade

A tese apresentada para cumprimento dos requisitos necessários à obtenção do Grau de Doutor em Filosofia (especialidade: Filosofia da Cultura).

Botnet cluster identification

Botnets are a group of computers infected with a specific sub-set of a malware family and controlled by one individual, called botmaster. This kind of networks are used not only, but also for virtual extorsion, spam campaigns and identity theft. They implement different types of evasion techniques that make it harder for one to group and detect botnet traffic. This thesis introduces one methodology, called CONDENSER, that outputs clusters through a self-organizing map and that identify domain names generated by an unknown pseudo-random seed that is known by the botnet herder(s). Aditionally DNS Crawler is proposed, this system saves historic DNS data for fast-flux and double fastflux detection, and is used to identify live C&Cs IPs used by real botnets. A program, called CHEWER, was developed to automate the calculation of the SVM parameters and features that better perform against the available domain names associated with DGAs. CONDENSER and DNS Crawler were developed with scalability in mind so the detection of fast-flux and double fast-flux networks become faster. We used a SVM for the DGA classififer, selecting a total of 11 attributes and achieving a Precision of 77,9% and a F-Measure of 83,2%. The feature selection method identified the 3 most significant attributes of the total set of attributes. For clustering, a Self-Organizing Map was used on a total of 81 attributes. The conclusions of this thesis were accepted in Botconf through a submited article. Botconf is known conferênce for research, mitigation and discovery of botnets tailled for the industry, where is presented current work and research. This conference is known for having security and anti-virus companies, law enforcement agencies and researchers.

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10(-3), n = 22,044), increased triglycerides (p = 2.6×10(-14), n = 93,440), increased waist-to-hip ratio (p = 1.8×10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10(-13), n = 96,748) and decreased BMI (p = 1.4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.

Variants in MTNR1B influence fasting glucose levels.

To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci.

Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study.

BACKGROUND In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. METHODOLOGY/PRINCIPAL FINDINGS The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-<1, 1-<4, ≥ 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95%CI 0.71, 1.00] when participants who drank ≥ 4 cups of tea per day were compared with non-drinkers (p(linear trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-<4 cups/day (HR = 0.93 [95%CI 0.81, 1.05]). Spline regression did not suggest a non-linear association (p(non-linearity) = 0.20). CONCLUSIONS/SIGNIFICANCE A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.