984 resultados para Gosson, Stephen, 1555-1624.
Resumo:
Histone methylation is a dynamic and reversible process proposed to directly impact on stem cell fate. The Jumonji (JmjC) domain-containing family of demethylases comprises 27 members which can demethylate mono-, di- and tri-methylated lysine residues of histone (or non-histone) targets. To evaluate their role in regulation of hematopoietic stem cell (HSC) behaviour we performed a RNAi-based screen and found that demethylases JARID1B (H3K4) and JHDM1F (H3K9) play opposing roles in regulation of HSC activity. Decrease in Jarid1b levels correlated with an in vitro expansion of HSC with preserved long term in vivo lympho-myeloid differentiation potential. Jarid1b knockdown was associated with an increase in expression levels of 5’ Hoxa cluster genes and CxCl5 , and reduced levels of Pu.1, Egr1 and Cav1. shRNA against Jhdmlf, in contrast, impaired hematopoietic reconstitution of bone marrow cells. Together, our studies identified Jarid1b as a negative, and Jhdmlf as a positive regulator of HSC activity.
Resumo:
La publicación ‘La accesibilidad y el diseño universal entendido por todos. De cómo Stephen Hawking viajó por el espacio’ es un libro al alcance de todos los públicos para acercarse a la accesibilidad universal, al diseño para todos y a la importancia de la igualdad de oportunidades para todas las personas. Sin duda, el autor se esfuerza con este libro en recopilar y sintetizar gran parte del conocimiento que había disperso en la materia, para condensarlo en una obra amena y apta para cualquier persona, independientemente si es profesional de la accesibilidad o está relacionada con el mundo de la discapacidad.
