Facilitation of sodium intake by combining noradrenaline into the lateral parabrachial nucleus with prazosin peripherally

Injections of noradrenaline into the lateral parabrachial nucleus (LPBN) increase arterial pressure and 1.8% NaCl intake and decrease water intake in rats treated with the diuretic furosemide (FURO) combined with a low dose of the angiotensin converting enzyme inhibitor captopril (CAP). In the present study, we investigated the influence of the pressor response elicited by noradrenaline injected into the LPBN on FURO + CAP-induced water and 1.8% NaCl intake. Male Holtzman rats with bilateral stainless steel guide-cannulas implanted into LPBN were used. Bilateral injections of noradrenaline (40 nmol/0.2 μl) into the LPBN increased FURO + CAP-induced 1.8% NaCl intake (12.2 ± 3.5, vs., saline: 4.2 ± 0.8 ml/180 min), reduced water intake and strongly increased arterial pressure (50 ± 7, vs. saline: 1 ± 1 mm Hg). The blockade of the α1 adrenoceptors with the prazosin injected intraperitoneally abolished the pressor response and increased 1.8% NaCl and water intake in rats treated with FURO + CAP combined with noradrenaline injected into the LPBN. The deactivation of baro and perhaps volume receptors due to the cardiovascular effects of prazosin is a mechanism that may facilitate water and NaCl intake in rats treated with FURO + CAP combined with noradrenaline injected into the LPBN. Therefore, the activation of α2 adrenoceptors with noradrenaline injected into the LPBN, at least in dose tested, may not completely remove the inhibitory signals produced by the activation of the cardiovascular receptors, particularly the signals that result from the extra activation of these receptors with the increase of arterial pressure. © 2013 Elsevier Inc.

Informe final de la Reunión de Expertos sobre Problemas de Facilitación y el Fortalecimiento de las Instituciones de Transporte = Final report of the Meeting of Experts on Facilitation Problems and the Strengthening of Transport Institutions

Informe final de la Reunion convocada para identificar los principales problemas de facilitacion que se confrontan en cada ambito, fijar prioridades y sugerir medidas que puedan contribuir a la superacion de dichos problemas por parte de los paises, y prestar asistencia a la Secretaria para establecer un programa de accion mas permanente y estable en la materia.

Procedimientos comerciales y facilitación comercial = Trade procedures and trade facilitation

Contiene los analisis de los expertos en problemas de facilitacion del comercio en lo que se refiere a simplificacion de los procedimientos comerciales a nivel nacional, su armonizacion y uniformacion a nivel regional y sub-regional; la situacion actual dentro de los mecanismos de integracion; las necesidades del fortalecimiento institucional; y la consideracion de posibles acciones de seguimiento.

Draft report of Meeting of Experts on Facilitation Problems and the Strengthening of Transport Institutions

Informe de la reunión sobre facilitación del comercio y fortalecimiento institucional del transporte internacional de los países miembros del CDCC. Contiene un resumen de los debates, recomendaciones para un programa de cooperación entre los países del Caribe, lista de participantes y lista de documentos.

Memorandum sobre facilitación del comercio y de su documentación en América Latina = Memorandum on trade facilitation and documentation in Latin America

Incluye Bibliografía

Trade facilitation within the forum, Asia-Pacific Economic Cooperation (APEC)

In terms of content, this article follows along the same lines as bulletin fal no. 167, although it reviews exclusively developments in the area of trade facilitation within the asia-pacific economic cooperation forum (apec). thus, the information contained in bulletin 167 has been updated and expanded. more analytical elements have also been incorporated.

Transport facilitation from the perspective of the Rotterdam Rules

This document takes a look at the important role transport facilitation plays in regional development and considers the implications of adopting the Rotterdam Rules for the transport sector.

The facilitation of trade in the European Union

In terms of its contents, this article is a natural continuation of FAL Bulletin No. 167. In that edition of the Bulletin, conceptual progress was made in defining the notion of ?facilitation of trade? and in outlining how this issue is dealt with in some international organizations; here, information referring to the European Union (EU) is presented in a detailed fashion.

EDI, facilitation and its impact on trade

On this issue of the Bulletin an attempt is made to illustrate how modern Trade Facilitation techniques, with an emphasis on EDI, affect different parts of the society such as business, commerce, transport, administration and government.