Análisis de los incentivos tributarios en la industria textil aplicado a la empresa exportadora de sombreros de paja toquilla Serrano Hat Export Cía. Ltda.

La actual crisis económica mundial y específicamente la del Ecuador, ha ocasionado que el actual gobierno busque la manera de incentivar la producción nacional, para dinamizar la economía. A más de los incentivos a la producción existen otros incentivos tanto económicos y tributarios, como de asesoría y capacitación, que buscan ayudar a las empresas exportadoras a mejorar su competitividad en el mercado internacional, atrayendo divisas al país para a la postre mejorar la Balanza de Pagos. En el presente trabajo de investigación, se realizó un estudio descriptivo, cuantitativo, deductivo, de análisis y de síntesis, con el objetivo de determinar si al realizar una correcta planificación tributaria, se podría evidenciar el posible beneficio de aprovechar determinados incentivos y su factibilidad de aplicación en el sector de exportaciones de sombreros de paja toquilla, específicamente en la empresa Serrano Hat Export Cía. Ltda. Como resultado, se pudo evidenciar que, existen incentivos tributarios a la producción y a la exportación de sombreros de paja toquilla, que en la empresa Serrano Hat Export Cía. Ltda. no son aprovechados, ya sea por desconocimiento, falta de interés o condiciones necesarias para su aplicación. Al igual que Serrano Hat, existen otras empresas de su sector, que podrían beneficiarse tanto económica como financieramente de este tipo de incentivos, siempre y cuando sean aplicados correctamente.

Host cell remodelling in malaria parasites: a new pool of potential drug targets

When in their human hosts, malaria parasites spend most of their time housed within vacuoles inside erythrocytes and hepatocytes. The parasites extensively modify their host cells to obtain nutrients, prevent host cell breakdown and avoid the immune system. To perform these modifications, malaria parasites export hundreds of effector proteins into their host cells and this process is best understood in the most lethal species to infect humans, Plasmodium falciparum. The effector proteins are synthesized within the parasite and following a proteolytic cleavage event in the endoplasmic reticulum and sorting of mature proteins into the correct vesicular trafficking pathway, they are transported to the parasite surface and released into the vacuole. The effector proteins are then unfolded before extrusion across the vacuole membrane by a unique translocon complex called Plasmodium translocon of exported proteins. After gaining access to the erythrocyte cytoplasm many effector proteins continue their journey to the erythrocyte surface by utilising various membranous structures established by the parasite. This complex trafficking pathway and a large number of the effector proteins are unique to Plasmodium parasites. This pathway could, therefore, be developed as new drug targets given that protein export and the functional role of these proteins are essential for parasite survival. This review explores known and potential drug targetable steps in the protein export pathway and strategies for discovering novel drug targets.

BRS Ártico: common bean cultivar with export-standard white grain.

BRS Ártico is a common bean cultivar with white grains with international standard size (62 g per 100 seeds), appropriate for cultivation in the Central region of Brazil and the state of Paraná. The cycle is semi-early, the yield potential 2677 kg ha-1 and BRS Ártico has moderate resistance to rust and curtobacterium wilt.

The Expanded Human Kallikrein (KLK) gene family : genomic organisation, tissue specific expression and potential functions

The tissue kallikreins are serine proteases encoded by highly conserved multigene families. The rodent kallikrein (KLK) families are particularly large, consisting of 13 26 genes clustered in one chromosomal locus. It has been recently recognised that the human KLK gene family is of a similar size (15 genes) with the identification of another 12 related genes (KLK4-KLK15) within and adjacent to the original human KLK locus (KLK1-3) on chromosome 19q13.4. The structural organisation and size of these new genes is similar to that of other KLK genes except for additional exons encoding 5 or 3 untranslated regions. Moreover, many of these genes have multiple mRNA transcripts, a trait not observed with rodent genes. Unlike all other kallikreins, the KLK4-KLK15 encoded proteases are less related (25–44%) and do not contain a conventional kallikrein loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression, suggesting evolutionary conservation of elements conferring tissue specificity. These genes are also expressed, to varying degrees, in a wider range of tissues suggesting a functional involvement of these newer human kallikrein proteases in a diverse range of physiological processes.