Free amino acids and sugars in rye grain: implications for acrylamide formation

Acrylamide forms from free asparagine and sugars during cooking, and products derived from the grain of cereals, including rye, contribute a large proportion of total dietary intake. In this study, free amino acid and sugar concentrations were measured in the grain of a range of rye varieties grown at locations in Hungary, France, Poland, and the United Kingdom and harvested in 2005, 2006, and 2007. Genetic and environmental (location and harvest year) effects on the levels of acrylamide precursors were assessed. The data showed free asparagine concentration to be the main determinant of acrylamide formation in heated rye flour, as it is in wheat. However, in contrast to wheat, sugar, particularly sucrose, concentration also correlated both with asparagine concentration and with acrylamide formed. Free asparagine concentration was shown to be under genetic (G), environmental (E), and integrated (G × E) control. The same was true for glucose, whereas maltose and fructose were affected mainly by environmental factors and sucrose was largely under genetic control. The ratio of variation due to varieties (genotype) to the total variation (a measure of heritability) for free asparagine concentration in the grain was 23%. Free asparagine concentration was closely associated with bran yield, whereas sugar concentration was associated with low Hagberg falling number. Rye grain was found to contain much higher concentrations of free proline than wheat grain, and less acrylamide formed per unit of asparagine in rye than in wheat flour.

Kinetic model for the formation of acrylamide during the finish-frying of commercial French fries

Acrylamide is formed from reducing sugars and asparagine during the preparation of French fries. The commercial preparation of French fries is a multistage process involving the preparation of frozen, par-fried potato strips for distribution to catering outlets, where they are finish-fried. The initial blanching, treatment in glucose solution, and par-frying steps are crucial because they determine the levels of precursors present at the beginning of the finish-frying process. To minimize the quantities of acrylamide in cooked fries, it is important to understand the impact of each stage on the formation of acrylamide. Acrylamide, amino acids, sugars, moisture, fat, and color were monitored at time intervals during the frying of potato strips that had been dipped in various concentrations of glucose and fructose during a typical pretreatment. A mathematical model based on the fundamental chemical reaction pathways of the finish-frying was developed, incorporating moisture and temperature gradients in the fries. This showed the contribution of both glucose and fructose to the generation of acrylamide and accurately predicted the acrylamide content of the final fries.

A comparative analysis of the accuracy and uncertainty in real estate and macroeconomic forecasts

We compare and contrast the accuracy and uncertainty in forecasts of rents with those for a variety of macroeconomic series. The results show that in general forecasters tend to be marginally more accurate in the case of macro-economic series than with rents. In common across all of the series, forecasts tend to be smoothed with forecasters under-estimating performance during economic booms, and vice-versa in recessions We find that property forecasts are affected by economic uncertainty, as measured by disagreement across the macro-forecasters. Increased uncertainty leads to increased dispersion in the rental forecasts and a reduction in forecast accuracy.

Rationality and momentum in real estate investment forecasts

This study examines the rationality and momentum in forecasts for rental, capital value and total returns for the real estate investment market in the United Kingdom. In order to investigate if forecasters are affected by the general economic conditions present at the time of forecast we incorporate into the analysis Gross Domestic Product(GDP) and the Default Spread (DS). The empirical findings show high levels of momentum in the forecasts, with highly persistent forecast errors. The results also indicate that forecasters are affected by adverse conditions. This is consistent with the finding that they tend to exhibit greater forecast error when the property market is underperforming and vice-versa.

Whatever works: proportionality as a constitutional doctrine

In The Global Model of Constitutional Rights Kai Möller claims that the proportionality test is underlain by an expansive moral right to autonomy. This putative right protects everything that advances one’s self-conception. It may of course be limited when balanced against other considerations such as the rights of others. But it always creates a duty on the state to justify the limitation. Möller further contends that the practice of proportionality can best be understood as protecting the right to autonomy. This review article summarizes the main tenets of Möller’s theory and criticizes them on two counts. First, it disputes the existence of a general right to autonomy; such a right places an unacceptably heavy burden on others. Second, it argues that we do not need to invoke a right to autonomy to explain and justify the main features of the practice of proportionality. Like other constitutional doctrines, proportionality is defensible, if it is grounded in pragmatic –mainly epistemic and institutional- considerations about how to increase overall rights compliance. These considerations are independent of any substantive theory of rights.

Regionalization strategy and performance: the moderating role of industry dynamism and top management team diversity

Purpose– This paper contributes to the debate about the performance implications of adopting a regional as opposed to a global strategic posture. The aim of this paper is to argue that the performance effects of a regionalization strategy vary based on the characteristics of the industry in which the MNE operates and the composition of its top management team (TMT). Design/methodology/approach– This analysis is based on a cross‐sectional dataset of 211 large European MNEs headquartered in four Western European economies at the end of 2005. Findings– Results show that firms adopting a regional orientation outperform MNEs with global strategic positioning. This positive relationship is less pronounced under conditions of industry dynamism and inter‐regional TMT diversity. Originality/value– The study contributes to our understanding of whether and under what conditions MNEs benefit from adopting a regional as opposed to a global strategic posture.

Shared authority: courts and legislatures in legal theory

This book advances a fresh philosophical account of the relationship between the legislature and courts, opposing the common conception of law, in which it is legislatures that primarily create the law, and courts that primarily apply it. This conception has eclectic affinities with legal positivism, and although it may have been a helpful intellectual tool in the past, it now increasingly generates more problems than it solves. For this reason, the author argues, legal philosophers are better off abandoning it. At the same time they are asked to dismantle the philosophical and doctrinal infrastructure that has been based on it and which has been hitherto largely unquestioned. In its place the book offers an alternative framework for understanding the role of courts and the legislature; a framework which is distinctly anti-positivist and which builds on Ronald Dworkin’s interpretive theory of law. But, contrary to Dworkin, it insists that legal duty is sensitive to the position one occupies in the project of governing; legal interpretation is not the solitary task of one super-judge, but a collaborative task structured by principles of institutional morality such as separation of powers which impose a moral duty on participants to respect each other's contributions. Moreover this collaborative task will often involve citizens taking an active role in their interaction with the law.

Assessing the accuracy and dispersion of real estate investment forecasts

Existing empirical evidence has frequently observed that professional forecasters are conservative and display herding behaviour. Whilst a large number of papers have considered equities as well as macroeconomic series, few have considered the accuracy of forecasts in alternative asset classes such as real estate. We consider the accuracy of forecasts for the UK commercial real estate market over the period 1999-2011. The results illustrate that forecasters display a tendency to under-estimate growth rates during strong market conditions and over-estimate when the market is performing poorly. This conservatism not only results in smoothed estimates but also implies that forecasters display herding behaviour. There is also a marked difference in the relative accuracy of capital and total returns versus rental figures. Whilst rental growth forecasts are relatively accurate, considerable inaccuracy is observed with respect to capital value and total returns.

Enteric coated spheres produced by extrusion/spheronization provide effective gastric protection and efficient release of live therapeutic bacteria

We present a novel but simple enteric coated sphere formulation containing probiotic bacteria (Lactobacillus casei). Oral delivery of live bacterial cells (LBC) requires live cells to survive firstly manufacturing processes and secondly GI microbicidal defenses including gastric acid. We incorporated live L. casei directly in the granulation liquid, followed by granulation, extrusion, spheronization, drying and spray coating to produce dried live probiotic spheres. A blend of MCC, calcium-crosslinked alginate, and lactose was developed that gave improved live cell survival during manufacturing, and gave excellent protection from gastric acid plus rapid release in intestinal conditions. No significant loss of viability was observed in all steps except drying, which resulted in approximately 1 log loss of viable cells. Eudragit coating was used to protect dried live cells from acid, and microcrystalline cellulose (MCC) was combined with sodium alginate to achieve efficient sphere disintegration leading to rapid and complete bacterial cell release in intestinal conditions. Viability and release of L. casei was evaluated in vitro in simulated GI conditions. Uncoated spheres gave partial acid protection, but enteric coated spheres effectively protected dried probiotic LBC from acid for 2 h, and subsequently released all viable cells within 1h of transfer into simulated intestinal fluid.

Copolimeros de propileno-etileno com baixos teores de etileno : estrutura, morfologia e propriedades

A estrutura básica predomínante encontrada em todos os copolímeros foi a de longos blocos de polipropileno cristalizáveis, separados por unidades isoladas de etileno, que atuaram como defeitos cristalínos, reduzindo o grau de cristalínidade, além da perfeição e da espessura dos cristais. O gradual aumento do teor de etileno nas amostras origínais, até aproximadamente5 moI % provocou redução progressiva no comprimento dos blocos de propileno em ambas as frações cristalizável e elastomérica. Acima daquela concentração, o etileno mostrou por principal efeito a elevação do teor de borracha de etileno-propileno(EPR), refletíndo-seem pronunciado aumento da resistência ao impacto dos copolímeros, com pouca alteração do comprimento das seqüências propiJênicas nas frações cristaJizáveJe elastomérica. A estrutura e a morfologia da borracha EPR gerada foram analisadas, observando-se sua excepcional dispersão na fase contínua cristalína. Análise das curvas de fusão por DSC, utilizando-se conceitos cínéticos, demonstrou a existência de uma energia de ativação aparente de fusão, associada à introdução de unidades etilênicas nas cadeias, e relacionada ao processo de fusão dos cristais poliméricos. A redução de cristalínidade das amostras e o aumento de mobilidade de cadeia da fase amorfa para teores crescentes de etileno resultaram em redução da rigidez dos copolímeros. Propriedades ópticas, como "haze" e brilho mostraram-se dependentesdo balanço entre o teor de cristais e o teor de borracha. Um balanço global das propriedades analisadas sugere uma composição ótima para aplicações típicas de copolímeros de propileno-etileno aquela com teores de etileno entre 4 e 6 moI % (aproximadamente 3 -4 % em massa).

Estudo da agregação de copolímeros anfifílicos de poliestireno e Poli[5-(N,N-Dialquilamino) Isopreno]

As propriedades em solução e a auto-associação de copolímeros em bloco de estireno e 5- (N,N-dialquilamino)isopreno foram estudados. Copolímeros di e tribloco são formados por um longo bloco de poliestireno, com um ou dois blocos menores de poli[5-(N,Ndialquilamino) isopreno] em uma ou ambas as extremidades. A polaridade do solvente é determinante na afinidade deste com um ou ambos blocos constituintes do polímero e, conseqüentemente, afetará as propriedades dinâmicas e estruturais do mesmo. Após a quaternização dos sistemas com dimetil sulfato, os agregados foram preparados pela prévia dissolução dos polímeros em um solvente orgânico e subsequente adição de água para induzir a agregação das cadeias insolúveis de PS. Solventes puros (DMF, THF e dioxano), bem como misturas de DMF e THF foram empregados como solvente comum. A concentração crítica de água (cwc) e as morfologias foram estudadas em função da natureza do solvente comum, da concentração inicial, arquitetura e massa molecular do copolímero, por espalhamento de luz estático e microscopia eletrônica de transmissão (MET), respectivamente. Determinou-se que tanto a cwc quanto as morfologias, são predominantemente influenciadas pela natureza do solvente comum. Alguns resultados inesperados foram encontrados para os copolímeros tribloco, incluindo a descoberta de uma nova morfologia formada a partir desse tipo de copolímero- a morfologia bowl-shape. Os agregados bowl-shaped, são essencialmente esferas bastante polidispersas, contendo um vazio alocado assimetricamente em seu interior. A fase contínua é composta de um arranjo de micelas inversas (núcleo de PAI e coroa de PS), sendo que as cadeias hidrofílicas de PAI circundam toda a estrutura na interface polímero/água. Acredita-se que a formação desta morfologia está sob controle cinético e não representa uma estrutura de equilíbrio. Foi proposto um possível mecanismo para a formação deste novo tipo de agregado.