272 resultados para Cueva de Canelobre


Relevância:

20.00% 20.00%

Publicador:

Resumo:

El presente artículo tiene como objetivo analizar la producción escrita del ecuatoriano Agustín Cueva y del boliviano René Zavaleta, respecto a los debates sobre la experiencia populista y sobre la matriz nacional popular en América Latina. Se presentarán sus principales contribuciones en clave comparada a partir de dos ejes analíticos: su caracterización respecto de las condiciones del surgimiento de la experiencia populista y del sujeto político al que refieren estas experiencias y la distinción que realizan los autores entre el populismo y la matriz nacional-popular. A partir de este último eje, en el cual residen sus principales argumentaciones teóricas y su defensa de la perspectiva marxista en el escenario latinoamericano, estudiaremos sus miradas sobre la construcción de hegemonía y los procesos de democratización en América Latina. El trabajo ofrece una reflexión de dos referentes del marxismo latinoamericano, cuyo pensamiento representa un legado para la Teoría Social Latinoamericana, a modo de propuesta para la reflexión sobre la reactualización de los debates en torno a la experiencia populista de la región en la última década.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

In this paper we analyze the set of Bronze Age bone tools recovered at the archaeological site of El Portalón of Cueva Mayor in the Sierra de Atapuerca (Burgos). The Bronze Age cultural period is the best represented in the cavity and its study has forced us to unify the different excavation and stratigraphical criteria undertaken from the earliest archaeological excavations developed by J.M. Apellániz during the 70s until the excavations of the current research team (EIA) since 2000. We propose here for the first time a relationship between the initial system of “beds” used by Apellániz and our recent sedimentary sequence that recognizes eleven stratigraphic levels radiometrically dated from the late Upper Pleistocene to the Middle Age. Within the bone industry assemblage we recognize a large variety of utensils and ornamental elements, with native and allochthonous features, that make evident a regional as well as long distance relationships of these populations of the interior of the Iberian Peninsula during the recent Prehistory.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Fondo Margaritainés Restrepo

Relevância:

10.00% 10.00%

Publicador:

Resumo:

In the present study, we analyzed AURKA and AURKB gene expression in 70 acute myeloid leukemia (AML) patients. There was no difference between leukemic samples and bone marrow mononuclear cells (BMMCs, n = 8) or CD34(+) progenitors (n = 10) from healthy donors. High white blood cells (WBC) counts were observed in the AURKA(+) and AURKB(+) groups, but no significant differences regarding age, gender, platelet counts or frequency of FLT3-ITD mutations. AURKA, but not AURKB, expression was independently associated with high WBC counts (OR: 3.15, 95% CI 1.07-9.24, p = 0.03). Moreover, the majority of cases that overexpressed AURKA and AURKB presented unfavorable cytogenetic abnormalities (p < 0.001). In conclusion, we described a significant association between overexpression of AURKA/B and cytogenetics findings in AML, which may be relevant to new therapeutic approaches, based on Aurora kinase inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

We report a case of acute monoblastic leukemia showing a jumping translocation with the MLL gene in a 17-year-old male. Classic cytogenetic and spectral karyotyping revealed a complex karyotype, and fluorescence in situ hybridization (FISH) demonstrated amplification of the MLL gene followed by translocation to chromosomes 15q, 17q, and 19q. In addition, molecular analyses showed a high expression of AURKA and AURKB genes. It is already known that overexpression of Aurora kinases is associated with chromosomal instability and poor prognosis. The formation of jumping translocations is a rare cytogenetic event and there is evidence pointing toward preferential involvement of the heterochromatin region of donor chromosomes and the telomere ends of recipient chromosomes. Jumping translocation with the MLL gene rearrangement is an uncommon phenomenon reported in leukemia cytogenetics. (C) 2010 Elsevier Inc. All rights reserved.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

We report a case of a 47-year-old man diagnosed with chronic lymphocytic leukemia (CLL) with two extra copies of chromosome 8. Classical cytogenetic analysis by the immunostimulatory combination of DSP30 and interleukin 2 showed tetrasomy of chromosome 8 in 60% of the metaphase cells (48,XY,+8,+8[12]/46,XY[8]). Spectral karyotype analysis confirmed the abnormality previously seen by G banding. Additionally, interphase fluorescence in situ hybridization using an LSI CEP 8 probe performed on peripheral blood cells without any stimulant agent showed tetrasomy of chromosome 8 in 54% of analyzed cells (108 of 200). To our knowledge, tetrasomy 8 as the sole chromosomal abnormality in CLL has not been previously described. The prognostic significance of tetrasomy 8 in CLL remains to be elucidated. However, the patient has been followed up in the outpatient hospital since 2004 without any therapeutic intervention and has so far remained stable. (C) 2010 Elsevier Inc. All rights reserved.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Adrenocortical tumors (ACT) are rare neoplasms of the adrenal glands accounting for 0.2% of all pediatric cancers. However, the incidence of ACT in South Brazilian children is 10 to 15 times greater than the worldwide incidence. Comparative genomic hybridization studies have revealed the presence of a high degree of chromosomal instability in ACT. We evaluated 16 ACT, 8 of them carcinomas and 8 adenomas. The presence of changes in DNA copy numbers was determined by comparative genomic hybridization, and the findings were validated by real-time polymerase chain reaction on the basis of IGF-II gene expression. The adenomas showed a mean of 19.7 imbalances per case, with the most frequent gain and loss being 4p15.1-p15.3 and 20p11.2-p13.2, respectively. The carcinomas presented with a mean of 35.5 imbalances per case, with the more frequent gain being 2q14.1-q24.3 and the more frequent losses being 3q21-q26.2, 20q12-qter, and 22q11.2-q13.3. The most frequent imbalances in both adenomas and carcinomas were gains of 1p21-p31.2, 2p12-p21 and loss of 20p11.2-p12. The expression of IGF-II mRNA (11p15.5) was higher in samples that presented with a gain of this region. It has been established that great genomic instability exists in pediatric ACT.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Tese de Doutoramento em Psicologia na área de especialização de Psicologia Cognitiva apresentada ao ISPA - Instituto Universitário

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Tese de Doutoramento apresentada ao ISPA - Instituto Universitário

Relevância:

10.00% 10.00%

Publicador:

Resumo:

In this paper we study decision making in situations where the individual’s preferences are not assumed to be complete. First, we identify conditions that are necessary and sufficient for choice behavior in general domains to be consistent with maximization of a possibly incomplete preference relation. In this model of maximally dominant choice, the agent defers/avoids choosing at those and only those menus where a most preferred option does not exist. This allows for simple explanations of conflict-induced deferral and choice overload. It also suggests a criterion for distinguishing between indifference and incomparability based on observable data. A simple extension of this model also incorporates decision costs and provides a theoretical framework that is compatible with the experimental design that we propose to elicit possibly incomplete preferences in the lab. The design builds on the introduction of monetary costs that induce choice of a most preferred feasible option if one exists and deferral otherwise. Based on this design we found evidence suggesting that a quarter of the subjects in our study had incomplete preferences, and that these made significantly more consistent choices than a group of subjects who were forced to choose. The latter effect, however, is mitigated once data on indifferences are accounted for.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Presenta información sobre los factores productivos de la caleta de Chorrillos, los cuales incluye los recursos marinos, pescadores, embarcaciones, redes, aparejos cangrejeros y pinteros; así como el rendimiento y costos de la pesca.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

En un estudio osteológico de los restos humanos de la Edad del Bronce de Cataluña se ha puesto de manifiesto la existencia, en esta época, de un suave y gradual proceso de difusión racial a lo largo del litoral noroeste del Mediterráneo, así como las influencias que éste ha tenido en el área catalana, donde aparece un elemento foráneo, de origen centroeuropeo, minoritario, localizado fundamentalmente en Solsona y de modo particular en tres yacimientos muy cercanos entre sí: los megalitos de El Collet, Clara y la cueva sepulcral de AigüesVives (fig. 1). Este aporte foráneo, relacionado sin duda con las prospecciones de metal y objetos de origen transpirenaico como la cerámica de apéndice de botón, aparece asentado en la zona reutilizando los sepulcros y mezclado con la población indígena, según muestran las abundantes formas de tránsito (Turbón, 1977, págs. 132, 340, 418 Y 326).

Relevância:

10.00% 10.00%

Publicador:

Resumo:

El llibre editat pel Dr. Ripoll Perelló s'emmarca en un deIs aspectes més destacats de la seva producció bibliografica, la de les recopilacions documentals, necrologiques i altres aspectes relacionats amb la historia de la prehistoria. Vull deixar clar que faig aquesta constatació en termes d' elogi i d' admiració, ja que les aportacions del Dr. Ripoll Perelló són molt valuoses per entendre moltes coses que continuen vigents en la prehistoria mundial.