Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application

Efficient and safe heparin anticoagulation has remained a problem for continuous renal replacement therapies and intermittent hemodialysis for patients with acute renal failure. To make heparin therapy safer for the patient with acute renal failure at high risk of bleeding, we have proposed regional heparinization of the circuit via an immobilized heparinase I filter. This study tested a device based on Taylor-Couette flow and simultaneous separation/reaction for efficacy and safety of heparin removal in a sheep model. Heparinase I was immobilized onto agarose beads via cyanogen bromide activation. The device, referred to as a vortex flow plasmapheretic reactor, consisted of two concentric cylinders, a priming volume of 45 ml, a microporous membrane for plasma separation, and an outer compartment where the immobilized heparinase I was fluidized separately from the blood cells. Manual white cell and platelet counts, hematocrit, total protein, and fibrinogen assays were performed. Heparin levels were indirectly measured via whole-blood recalcification times (WBRTs). The vortex flow plasmapheretic reactor maintained significantly higher heparin levels in the extracorporeal circuit than in the sheep (device inlet WBRTs were 1.5 times the device outlet WBRTs) with no hemolysis. The reactor treatment did not effect any physiologically significant changes in complete blood cell counts, platelets, and protein levels for up to 2 hr of operation. Furthermore, gross necropsy and histopathology did not show any significant abnormalities in the kidney, liver, heart, brain, and spleen.

Brachiopod genera of the suborders Orthoidea and Pentameroidea, by Charles Schuchert and G. Arthur Cooper.

4. pt.1

Charles S. Smith

On mat: Calvert Bros. & Taylor; Nashville, Tenn.

The reform act, 1832; the correspondence of the late Earl Grey with His Majesty King William IV. and with Sir Herbert Taylor, from Nov. 1830 to June 1832;

Mode of access: Internet.

Charles Kingsley, his letters, and memories of his life /

"This edition ... limited to one thousand sets of which this is number 672."

The novels, poems, and memories of Charles Kingsley.

Half-title.

The Inscriptions and epitaphs in the Bunhill-fields burial-ground, with alphabetical index : Reprinted from a volume published in 1717, in the possession of ... Charles Reed.

With reproduction of original t.-p.

Charles Kingsley, his letters and memories of his life /

Limited edition of 1000 copies. This is no. 546.

Two years ago / Charles Kingsley ; with an introduction by Maurice Kingsley.

Limited edition of 350 copies of which this is number 118.

The pennyles pilgrimage or The money-lesse perambulation of John Taylor, alias the Kings Majesties water-poet. How he travailed on foot from London to Edenborough in Scotland not carrying any money to or fro.

In Hindley, Charles, ed. The old book collector's miscellany. vol. 2. London, 1872)

Advertising Colonial Romance and Imperial Masculinity: The Promotion of Philip Meadows Taylor's Novels in Britain

The comments of Charles Kegan Paul, the Victorian publisher who was involved in publishing the novels of the nineteenth-century British-Indian author Philip Meadows Taylor as single volume reprints in the 1880s, are illuminating. They are indicative of the publisher's position with regard to publishing - that there was often no correlation between commercial success and the artistic merit of a work. According to Kegan Paul, a substandard or mediocre text would be commercially successful as long it met a perceived want on the part of the public. In effect, the ruminations of the publisher suggests that a firm desirous of acquiring commercial success for a work should be an astute judge of the pre-existing wants of consumers within the market. Yet Theodor Adorno, writing in the mid-twentieth century, offers an entirely distinctive perspective to Kegan Paul's observations, arguing that there is nothing foreordained about consumer demand for certain cultural tropes or productions. They in fact are driven by an industry that preempts and conditions the possible reactions of the consumer. Both Kegan Paul's and Adorno's insights are illuminating when it comes to addressing the key issues explored in this essay. Kegan Paul's comments allude to the ways in which the publisher's promotion of Philip Meadows Taylor's fictional depictions of India and its peoples were to a large extent driven in the mid- to late-nineteenth century by their expectations of what metropolitan readers desired at any given time, whereas Adorno's insights reveal the ways in which British-Indian narratives and the public identity of their authors were not assured in advance, but were, to a large extent, engineered by the publishing industry and the literary marketplace.

Imagen del mundo, percepción y descripción de la naturaleza. Un estudio comparado en torno a las presuposiciones onto-epistemológicas en la poesía romántica inglesa y la prosa científica de Charles Darwin

615 p.