Lógica, investigação e democracia no discurso educacional de John Dewey

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Influência de materiais de cobertura e de alturas de cama, nos índices de conforto térmico e no desempenho de frangos de corte, em Dourados - MS

Pós-graduação em Agronomia (Energia na Agricultura) - FCA

Adubação fosfatada no desenvolvimento de Hemerocallis fulva L.

In clayey Oxisol from the Brazilian Cerrado, where there is high P fixation, the phosphorus fertilization is necessary to increase the growth and flowering of ornamental plants. Thus, the objective of this study was to analyze the development of Hemerocallis as affected by phosphorus application in clayey Oxisol (Typic Haplustox). The experiment was conducted at the Gardening area of University Federal of Grande Dourados (UFGD) in Dourados-MS, Brazil. The experimental design was a randomized block with four replications. The treatments consisted of four P2O5 rates (0, 250, 500, 1000 kg ha(-1)) using simple superphosphate as source. The experimental unit was composed of one Hemerocallis fulva 'Flore Pleno' plant, grown in a plastic pot (5 liters). Phosphorus fertilization increased linearly the concentration of phosphorus in the soil; the plant had maximum absorption (5.26 g kg(-1)) with the calculated dose of 727 kg ha(-1) P2O5. H. fulva has a root system that develops best under high availability of P, however, for aerial part, the maximum of shoots fresh mass (451.1 g) was obtained with 427 kg ha(-1) of P2O5. Number of flower buds, flower diameter and height flower stalks were higher in the presence of phosphorus.

Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Mapeando o conhecimento em sistemas de classificação de bibliotecas

This study explores, in 3 steps, how the 3 main library classification systems, the Library of Congress Classification, the Dewey Decimal Classification, and the Universal Decimal Classification, cover human knowledge. First, we mapped the knowledge covered by the 3 systems. We used the “10 Pillars of Knowledge: Map of Human Knowledge”, which comprises 10 pillars, as an evaluative model. We mapped all the subject-based classes and subclasses that are part of the first 2 levels of the 3 hierarchical structures. Then, we zoomed into each of the 10 pillars and analyzed how the three systems cover the 10 knowledge domains. Finally, we focused on the 3 library systems. Based on the way each one of them covers the 10 knowledge domains, it is evident that they failed to adequately and systematically present contemporary human knowledge. They are unsystematic and biased, and, at the top 2 levels of the hierarchical structures, they are incomplete.

Structural insights into substrate binding of brown spider venom class II phospholipases D

Phospholipases D (PLDs), the major dermonecrotic factors from brown spider venoms, trigger a range of biological reactions both in vitro and in vivo. Despite their clinical relevance in loxoscelism, structural data is restricted to the apo-form of these enzymes, which has been instrumental in understanding the functional differences between the class I and II spider PLDs. The crystal structures of the native class II PLD from Loxosceles intermedia complexed with myo-inositol 1-phosphate and the inactive mutant H12A complexed with fatty acids indicate the existence of a strong ligand-dependent conformation change of the highly conserved aromatic residues, Tyr 223 and Trp225 indicating their roles in substrate binding. These results provided insights into the structural determinants for substrate recognition and binding by class II PLDs.

Prevalence of metabolic syndrome in elderly Japanese-Brazilians

Background: Prevalence of individuals with a high cardiovascular risk is elevated in elderly populations. Although metabolic syndrome (MS) increases cardiovascular risk, information is scarce on the prevalence of MS in the elderly. In this study we assessed MS prevalence in a population of elderly Japanese-Brazilians using different MS definitions according to waist circumference cutoff values. Material/Methods: We studied 339 elderly subjects, 44.8% males, aged between 60 to 88 years (70.1 +/- 6.8). MS was defined according to criteria proposed by the Joint Interim Statement in 2009. As waist circumference cutoff point values remain controversial for Asian and Japanese populations, we employed 3 different cutoffs that are commonly used in Japanese epidemiological studies: 1) >90 cm for men and >80 cm for women; 2) >85 cm for men and >90 cm for women; 3) >85 cm for men and >80 cm for women. Results: MS prevalence ranged from 59.9% to 65.8% according to the different definitions. We observed 90% concordance and no statistical difference (p>0.05) in MS prevalence between the 3 definitions. MS diagnosis according to all 3 cutoff values was found in 55.8% of our population, while in only 34.2% was MS discarded by all cutoffs. The prevalence of altered MS components was as follows: arterial blood pressure 82%, fasting glycemia 65.8%, triglyceride 43.4%, and HDL-C levels 36.9%. Conclusions: Elderly Japanese-Brazilians present high metabolic syndrome prevalence independent of waist circumference cutoff values. Concordance between the 3 definitions is high, suggesting that all 3 cutoff values yield similar metabolic syndrome prevalence values in this population.

Israel und sein Land : Reden u. Ansprachen

von Chaim Weizmann. Mit e. Geleitw. von A. Einstein

Die Kolonisationsfinanzen der Jewish Agency

von Viktor Chajim Arlosoroff

Biblisches und talmudisches Lexikon

O.B. Gawronsky ; bearb. von Ch. Tschernowitz

Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination

BACKGROUND L-serine plays an essential role in neuronal development and function. Although a non-essential amino acid, L-serine must be synthesised within the brain because of its poor permeability by the blood-brain barrier. Within the brain, its synthesis is confined to astrocytes, and its shuttle to neuronal cells is performed by a dedicated neutral amino acid transporter, ASCT1. METHODS AND RESULTS Using exome analysis we identified the recessive mutations, p.E256K, p.L315fs, and p.R457W, in SLC1A4, the gene encoding ASCT1, in patients with developmental delay, microcephaly and hypomyelination; seizure disorder was variably present. When expressed in a heterologous system, the mutations did not affect the protein level at the plasma membrane but abolished or markedly reduced L-serine transport for p.R457W and p.E256K mutations, respectively. Interestingly, p.E256K mutation displayed a lower L-serine and alanine affinity but the same substrate selectivity as wild-type ASCT1. CONCLUSIONS The clinical phenotype of ASCT1 deficiency is reminiscent of defects in L-serine biosynthesis. The data underscore that ASCT1 is essential in brain serine transport. The SLC1A4 p.E256K mutation has a carrier frequency of 0.7% in the Ashkenazi-Jewish population and should be added to the carrier screening panel in this community.

Der sanzer tzadik rav Ḥajim Halbršṭam : zain leben, zain wirken, zaine ṭhaṭen, zain ṭheṭigkeiṭ in ḥasidus

dertzehlṭ tzum erśṭen mol in a rain jidiše šprach fun Jehošua Roker