Sobre a filosofia da mente de John Searle

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Cultura de paz e UNESCO: uma analítica documental da gestão de corpos no Brasil

Este estudo objetivou realizar uma analítica do poder no documento “Declaração e Programa de Ação sobre uma Cultura de Paz”, documento este legitimado, em 1999, por uma Assembleia Geral das Nações Unidas, fixando-se assim como norte prioritário das práticas da agência intitulada Organização das Nações Unidas para a Educação, a Ciência e a Cultura (UNESCO). Foram utilizados como instrumentos de análise norteadores metodológicos vinculados a muitos operadores retirados do aporte teórico-metodológico produzido por Michel Foucault. Caminhou-se na direção de pensar, problematizar e produzir saber a partir deste movimento de desmontagem de documentos monumentos, tendo como eixo principal o conceito de “Cultura de Paz”. Este mote de cultura de paz possui sua existência atrelada à história das Nações Unidas e às suas agências, sendo produzido e sistematizado a partir de um conjunto de crenças, práticas e associações, que lhe possibilitaram ganhar visibilidade e poder, popularizando-o e tornando-o uma das produções discursivas mais significativas da contemporaneidade. Percorrendo necessariamente por diagonais entre as temáticas UNESCO, governamentalidade e produção de subjetividade, finalizamos esta dissertação com a apresentação do debate a respeito das práticas denominadas cultura de paz e seus efeitos no cotidiano em termos de saber e poder.

Effect of hypoxia and hyperglycemia on cell bioenergetics

Mitochondria have a central role in energy supply in cells, ROS production and apoptosis and have been implicated in several human disease and mitochondrial dysfunctions in hypoxia have been related with disorders like Type II Diabetes, Alzheimer Disease, inflammation, cancer and ischemia/reperfusion in heart. When oxygen availability becomes limiting in cells, mitochondrial functions are modulated to allow biologic adaptation. Cells exposed to a reduced oxygen concentration readily respond by adaptive mechanisms to maintain the physiological ATP/ADP ratio, essential for their functions and survival. In the beginning, the AMP-activated protein kinase (AMPK) pathway is activated, but the responsiveness to prolonged hypoxia requires the stimulation of hypoxia-inducible factors (HIFs). In this work we report a study of the mitochondrial bioenergetics of primary cells exposed to a prolonged hypoxic period . To shine light on this issue we examined the bioenergetics of fibroblast mitochondria cultured in hypoxic atmospheres (1% O2) for 72 hours. Here we report on the mitochondrial organization in cells and on their contribution to the cellular energy state. Our results indicate that prolonged hypoxia cause a significant reduction of mitochondrial mass and of the quantity of the oxidative phosphorylation complexes. Hypoxia is also responsible to damage mitochondrial complexes as shown after normalization versus citrate synthase activity. HIF-1α plays a pivotal role in wound healing, and its expression in the multistage process of normal wound healing has been well characterized, it is necessary for cell motility, expression of angiogenic growth factor and recruitment of endothelial progenitor cells. We studied hypoxia in the pathological status of diabetes and complications of diabetes and we evaluated the combined effect of hyperglycemia and hypoxia on human dermal fibroblasts (HDFs) and human dermal micro-vascular endothelial cells (HDMECs) that were grown in high glucose, low glucose concentrations and mannitol as control for the osmotic challenge.

Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia

Intravascular transplantation of neural stem cells represents a minimally invasive therapeutic approach for the treatment of central nervous system diseases. The cellular biodistribution after intravascular injection needs to be analyzed to determine the ideal delivery modality. We studied the biodistribution and efficiency of targeted central nervous system delivery comparing intravenous and intra-arterial (IA) administration of neural stem cells after brain ischemia.

Rechnergestützte Planung von Distributionszentren durch Einsatz der Graphentheorie

Obwohl Distributionszentren (DZ) zentrale Kernelemente von Lieferketten darstellen, lässt sich gegenwärtig keine strukturierte Methodik finden, um diese objektiv, systematisch und insbesondere ganzheitlich über alle Funktionsbereiche hinweg – vom Wareneingang über die Kommissionierung bis zum Warenausgang – zu planen. Der vorliegende Artikel befasst sich mit dieser wissenschaftlichen Lücke und beschreibt wie mit Hilfe von analytisch modellierten Standardmodulen innerhalb der verschiedenen Funktionsbereiche eines DZ durch Anwendung eines graphentheoretischen Ansatzes funktionsbereichsübergreifende Varianten von DZ generiert werden können. Zur automatisierten Ermittlung der optimalen Standardmodulkombination bzw. der optimalen DZ-Variante werden modifizierte Algorithmen zur Findung der kürzesten Wege innerhalb eines Graphen angewendet.

In Memory of Dr. Ali Al-Gritly (1913-1982): His Views on Egypt's experience with Socialism

This essay reexamines the great contributions made by Dr. Ali Al-Gritly to Egypt. He was the finance minister for a short period at the beginning of the 1950s and later was appointed as chairman of the Bank of Alexandria. In 1966, he completed a book (Al-Gritly [1966 (1974)]) on the economic history of Egypt. However, the book was banned from publication due to irresistible circumstances. At that time, with Arab Socialism on the ascendance, his views on certain policies were not welcomed by the top political hierarchy. In 1974, the book was finally allowed to be published, and he wrote and published another book in 1977 (Al-Gritly [1977]) on the development of the Open Door Policy and the new economic policies accompanying it.

Providing health information to the general public: a survey of current practices in academic health sciences libraries*

A questionnaire was mailed to 148 publicly and privately supported academic health sciences libraries affiliated with Association of American Medical Colleges (AAMC)–accredited medical schools in the United States and Canada to determine level of access and services provided to the general public. For purposes of this study, “general public” was defined as nonaffiliated students or health care professionals, attorneys and other nonhealth-related professionals, patients from affiliated or other hospitals or clinics, and general consumers. One hundred five (71%) libraries responded. Results showed 98% of publicly supported libraries and 88% of privately supported libraries provided access to some or all of the general public. Publicly supported libraries saw greater numbers of public patrons, often provided more services, and were more likely to circulate materials from their collections than were privately supported libraries. A significant number of academic health sciences libraries housed a collection of consumer-oriented materials and many provided some level of document delivery service, usually for a fee. Most allowed the public to use some or all library computers. Results of this study indicated that academic health sciences libraries played a significant role in serving the information-seeking public and suggested a need to develop written policies or guidelines covering the services that will be provided to minimize the impact of this service on primary clientele.

The food products of Canada and names of some exporters.

Report by Jas. W. Robertson, Commissioner of Agriculture and Dairying.

Vermilion River (Illinois River Basin) area assessment.

The Critical Trends Assessment Program (CTAP) documents changes in ecological conditions.