Use of PCR to estimate the prevalence of Equus caballus papillomavirus in aural plaques in horses

Aural plaques occur on the skin of the medial surface of the pinnae of horses. In this study the presence of Equus caballus papillomavirus (EcPV)-3 and -4 DNA was assessed in 45 such plaques using a 'touchdown' PCR. Papillomaviruses (PVs) were detected in 62.3% (28/45) of samples: EcPV-3 and -4 DNA in 8.89% (4/45) and 37.78% (17/45) of samples, respectively, with 15.56% (7/45) of samples exhibiting co-infection. Viral DNA was not detected in 37.78% (17/45) of samples, suggesting the possible existence of other equine PVs. Neither EcPV-3 nor -4 were detected in negative control skin. This study is the first to evaluate the prevalence of these two viruses in equine aural plaques. © 2013 Elsevier Ltd.

Pesquisa do DNA viral de papilomavirus equino em lesões de placa aural

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Pesquisa do DNA viral de papilomavirus equino em lesões de placa aural

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Validation of the Subjective Handicap of Epilepsy (SHE) in Brazilian patients with epilepsy

The objectives of the study were to translate and adapt the Subjective Handicap of Epilepsy (SHE) instrument to Brazilian Portuguese and to determine its psychometric properties for the evaluation of quality of life in patients with epilepsy. A sample of 448 adult patients with epilepsy with different clinical profiles (investigation, preoperative period, postoperative period, and drug treatment follow-up) was evaluated with the SHE and the Epilepsy Surgery Inventory (ESI-55). Exploratory factorial analysis demonstrated that four factors explained 60.47% of the variance and were sensitive to discriminate the different clinical groups, with the preoperative group having the poorest quality of life. Internal consistency ranged from 0.92 to 0.96, and concurrent validity with the ESI-55 was moderate/strong (0.32-0.70). Test-retest reliability was confirmed, with an ICC value of 0.54 (2 days), 0.91 (7 days), and 0.97 (30 days). The SHE had satisfactory psychometric qualities for use in the Brazilian population, similar to those of the original version. The instrument seems to be more adequate in psychometric terms for the postoperative and drug treatment follow-up groups, and its use should be encouraged. (c) 2012 Elsevier Inc. All rights reserved.

Relação entre limiares audiométricos, handicap e tempo para procura de tratamento da deficiência auditiva

OBJETIVO: Verificar a relação entre limiares audiométricos, autopercepção do handicap e tempo para procura de tratamento em indivíduos atendidos em um serviço público de saúde auditiva. MÉTODOS: Trata-se de estudo retrospectivo, com análise de prontuários de 152 idosos e 48 adultos deficientes auditivos. As médias de limiares audiométricos ISO (500 Hz a 4 kHz) e de altas frequências (2 a 6 kHz), os limiares de reconhecimento de fala e a pontuação total e das subescalas social e emocional dos Questionários de Handicap Auditivo para Adultos (HHIA) e Idosos (HHIE) foram comparados com o tempo compreendido entre o início da queixa auditiva e o momento da procura por tratamento. RESULTADOS: O tempo médio para procura do tratamento foi de 7,6 anos. Não houve diferença entre adultos e idosos para as médias dos limiares ISO e de alta frequência, pontuação total e das subescalas do HHIA/E, e tempo para procura do tratamento. Correlações negativas fracas, porém significativas, foram observadas entre os limiares audiométricos e o tempo para procura de tratamento. Não foram encontradas relações entre o tempo para procura de tratamento e as variáveis referentes à escolaridade, nível sócio econômico e percepção do handicap. CONCLUSÃO: Os limiares audiométricos parecem influenciar a procura pelo tratamento. A despeito dos avanços tecnológicos e mudanças no acesso à informação e ao tratamento, o tempo de procura pelo tratamento é similar ao encontrado há 30 anos.

Il filo di Arianna - Una ricerca multi ed interdisciplinare per il superamento degli handicap che la x fragile propone

Il seguente lavoro di tesi verte sulla ricerca-azione formazione triennale “Il Filo di Arianna” realizzata in convenzione tra Associazione Italiana Sindrome X Fragile e Dipartimento Di Scienze dell’Educazione – Università di Bologna, finalizzata alla superamento degli handicap che la X fragile propone. La ricerca ha un fuoco in Pedagogia Speciale e un carattere multidisciplinare e inter istituzionale grazie alla sinergia con l’area neuroriabilitativa (Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana di Roma) e l’area della Psicologia Clinica (Ospedale Bambin Gesù di Roma). Il lavoro di tesi descrive il percorso per giungere alle linee guida di intervento scaturite dalla ricerca, per il potenziamento cognitivo ed affettivo di bambini e persone con x fragile nei contesti di casa, scuola e tempo libero.

Congenital aural atresia associated with agenesis of internal carotid artery in a girl with a FOXI3 deletion.

We report on the molecular characterization of a microdeletion of approximately 2.5 Mb at 2p11.2 in a female baby with left congenital aural atresia, microtia, and ipsilateral internal carotid artery agenesis. The deletion was characterized by fluorescence in situ hybridization, array comparative genomic hybridization, and whole genome re-sequencing. Among the genes present in the deleted region, we focused our attention on the FOXI3 gene. Foxi3 is a member of the Foxi class of Forkhead transcription factors. In mouse, chicken and zebrafish Foxi3 homologues are expressed in the ectoderm and endoderm giving rise to elements of the jaw as well as external, middle and inner ear. Homozygous Foxi3-/- mice have recently been generated and show a complete absence of the inner, middle, and external ears as well as severe defects in the jaw and palate. Recently, a 7-bp duplication within exon 1 of FOXI3 that produces a frameshift and a premature stop codon was found in hairless dogs. Mild malformations of the outer auditory canal (closed ear canal) and ear lobe have also been noted in a fraction of FOXI3 heterozygote Peruvian hairless dogs. Based on the phenotypes of Foxi3 mutant animals, we propose that FOXI3 may be responsible for the phenotypic features of our patient. Further characterization of the genomic region and the analysis of similar patients may help to demonstrate this point. © 2015 Wiley Periodicals, Inc.

Guides for vocational rehabilitation of the deaf and the hard of hearing : reports of the committees of the first Institute for Special Workers for the Aural Disabled, Washington, D.C., November 28-December 2, 1949.

Mode of access: Internet.

The diseases of the ear : their diagnosis and treatment : a textbook of aural surgery in the form of academical lectures /

Mode of access: Internet.

Life's handicap : being stories of my own people /

Mode of access: Internet.

Social degradation : a study of the handicap of poverty.

Mode of access: Internet.

Who are they? : a profile of unemployed older workers in selected age groups by occupation, and in terms of sex, education and handicap status /

WI docs. no.: EMP 2.2:O 5

Operator, organizational, and direct support maintenance manual : detecting set, mine, aural indication, 10V DC operating power, portable, transistorized, w/case AN/PSS-11 (Polan models P153 and P158) NSN 6665-00-966-9071, (Polan model P190) NSN 6665-00-181-0432, (Oregon Technical Products model MD-M) ... (The VP Company model VP200) ... (Fourdee model 4D5000) ....

Includes index.